Triazine derivative and pharmaceutical composition comprising the same

ABSTRACT

The present invention provides a novel P2X 3  and/or P2X 2/3  receptor antagonist. 
     A compound represented by the formula (I): 
                         
wherein R a , R b  and R c  are,
     (a) R a  and R b  are taken together ═Z; and R c  is a group represented by R 1c ; or   (b) R b  and R c  are taken together to form a bond; and R a  is a group represented by —Y—R 1a ;   R 1a  and R 1c  are each independently hydrogen, substituted or unsubstituted alkyl, etc.;   R 2  and R 3  are each independently substituted or unsubstituted aryl, etc.;   R 4a  and R 4b  are each independently hydrogen, substituted or unsubstituted alkyl, etc.;   X is —N(R 5 )—, etc.;   R 5  is hydrogen, substituted or unsubstituted lower alkyl, etc.;   —Y— is —O—, etc.;   ═Z is ═O, etc.; and   n is an integer of 0 to 4.

This is a division of application Ser. No. 13/201,209, filed Aug. 30, 2011, which is the U.S. national stage application of International Application No. PCT/JP2010/051920, filed Feb. 10, 2010, which claims the benefit of priority from Japanese Application No. 2009266903, filed Nov. 25, 2009, and Japanese Application No. 2009-031520, filed on Feb. 13, 2009. All of these applications are herein incorporated by reference in their entireties.

TECHNICAL FIELD

The invention relates to P2X receptor, specifically to a compound useful for the treatment of diseases or conditions associated with a P2X₃ receptor, specifically to a P2X₃ and/or P2X_(2/3) receptor, and a pharmaceutical composition comprising such compound.

BACKGROUND ART

ATP (adenosine triphosphate) is known to serve as a source of energy in cells and a substrate of phosphorylation, as well as an extracellular messenger. It is known that ATP is released from a cell by various stimulation such as cellular injury, inflammation, nociceptive stimulus, reduced blood oxygen level, and also known to be released together with another messenger from a primary sensory nerve terminal. ATP thus released mediates various extracellular signal transductions through an ATP receptor (Non-Patent Document 4, Non-Patent Document 5).

ATP receptor is categorized into ionotropic P2X family and G protein-coupled P2Y family. For P2X family, seven subtypes have been reported, and a member of this family forms a homo-trimeric structure or a hetero-trimeric structure together with another member of this subtype and functions as a non-specific cation channel (Non-Patent Document 6).

ATP is known to cause pain, and studies with P2X₃ knockout and knockdown methodologies have shown that P2X₃ receptor mediates transmission of chronic pain. P2X₃ receptors are expressed in a specific manner on peripheral sensory nerve to form a homo-complex or hetero-complex with P2X₂ (P2X_(2/3)) (Non-Patent Document 1).

Later, the compound A-317491 was reported as a specific antagonist to P2X₃ and P2X_(2/3) receptors. A-317491 is tri-substituted-N—[(1S)-1,2,3,4-tetrahydro-1-naphthalenyl]benzamide derivative represented by the formula:

(Patent Document 1). It was reported to exhibit an antagonist activity to P2X₃ and P2X_(2/3) receptors and analgesic action in neuropathic pain model and inflammatory pain model (Non-Patent Document 7). This indicates that pain sensation is transmitted via P2X₃ or P2X_(2/3) receptor and that a P2X₃ or P2X_(2/3) receptor antagonist is useful as an analgesic. Also, compounds that exhibit P2X₃ or P2X_(2/3) receptor antagonizing effect are described in Patent Documents 2-7.

Additionally, it was recently reported that vesical reflex was strongly reduced in P2X₃ knockout mouse (Non-Patent Document 2), suggesting that a P2X₃ antagonist is useful in the treatment of diseases caused by overactive bladder.

Patent document 8, 9, 10 and 11 discloses that the compounds having similar chemical structures to the compound of the invention, however, does not disclose that the compounds having an analgesic effect and a P2X₃ or P2X_(2/3) receptor antagonizing effect. Non-Patent documents 8 disclose that the compounds having similar chemical structures to the compound of the invention and an analgesic effect, however, does not disclose that the compound having a P2X₃ or P2X_(2/3) receptor antagonizing effect.

[Patent Document 1]WO02/094767

[Patent Document 2]WO2005/095359

[Patent Document 3]US20070037974

[Patent Document 4]US20070049758

[Patent Document 5]US20070049610

[Patent Document 6]US20070049609

[Patent Document 7]US20070049534

[Patent Document 8]JP12-072757

[Patent Document 9]WO2006/104713

[Patent Document 10]WO2006/104715

[Patent Document 11]WO2006/102112

[Non-Patent Document 1] Neuroscientist 11 (2005) 345-356

[Non-Patent Document 2]J. Physiol. 567.2 (2005) 621-639

[Non-Patent Document 3] Expert Opin. Ther. Patens (2006) 16(8) 113-1127

[Non-Patent Document 4] J. Physiol. (2003), 554(2), 301-308

[Non-Patent Document 5] J. Physiology (2003), 553(3), 683-694

[Non-Patent Document 6] Pflungers Arch Eur J physiol (2006), 452, 513-537

[Non-Patent Document 7] PNAS (2002), 99(26), 17179-17184

[Non-Patent Document 8] J. Med. Chem. (2008), 51(23), 7635-7639

DISCLOSURE OF INVENTION Problems to be Resolved by the Invention

The present invention provides a novel P2X₃ and/or P2X_(2/3) receptor antagonist.

Means of Solving the Problems

During studies to solve the problems described above, the inventors have discovered novel compounds that bind specifically to P2X₃ and/or P2X_(2/3) receptor and exhibit an antagonizing effect, and thus, achieved the inventions described bellow.

Effect of the Invention

The compound of the invention has antagonizing effect on P2X₃ and/or P2X_(2/3) receptor and is useful in the treatment of diseases or conditions associated with a P2X₃ and/or P2X_(2/3) receptor, such as chronic pain, overactive bladder, etc.

MODE FOR CARRYING OUT THE INVENTION

(1) A compound represented by the formula (I):

wherein

-   R^(a), R^(b) and R^(c) are, -   (a) R^(a) and R^(b) are taken together ═Z; -   ═Z is ═O, ═S or ═N—R⁶; -   R⁶ is hydrogen, substituted or unsubstituted alkyl, substituted or     unsubstituted alkenyl, substituted or unsubstituted alkynyl,     substituted or unsubstituted cycloalkyl, substituted or     unsubstituted cycloalkenyl, a substituted or unsubstituted     non-aromatic heterocyclic group, substituted or unsubstituted aryl,     or substituted or unsubstituted heteroaryl; -   R^(c) is a group represented by R^(1c); -   R^(1c) is hydrogen, substituted or unsubstituted alkyl, substituted     or unsubstituted alkenyl, substituted or unsubstituted alkynyl,     substituted or unsubstituted acyl, substituted or unsubstituted     cycloalkyl, substituted or unsubstituted cycloalkenyl, a substituted     or unsubstituted non-aromatic heterocyclic group, substituted or     unsubstituted aryl, or substituted or unsubstituted heteroaryl; or -   (b) R^(b) and R^(c) are taken together to form a bond; -   R^(a) is a group represented by —Y—R^(1a); -   R^(1a) is hydrogen, substituted or unsubstituted alkyl, substituted     or unsubstituted alkenyl, substituted or unsubstituted alkynyl,     substituted or unsubstituted acyl, substituted or unsubstituted     cycloalkyl, substituted or unsubstituted cycloalkenyl, a substituted     or unsubstituted non-aromatic heterocyclic group, substituted or     unsubstituted aryl or substituted or unsubstituted heteroaryl: -   —Y— is —O—, —S—, —N(R⁷)— or —C(R^(8a)R^(8b))—; -   R⁷ is hydrogen, substituted or unsubstituted alkyl, substituted or     unsubstituted acyl, or R⁷ and R^(1a) are taken together to form a     substituted or unsubstituted nitrogen-containing non-aromatic     heterocyclic group; -   R^(8a) and R^(8b) are each independently hydrogen, halogen, or     substituted or unsubstituted alkyl: -   n is an integer of 0 to 4; -   R² is hydrogen, substituted or unsubstituted alkyl, substituted or     unsubstituted alkenyl, substituted or unsubstituted alkynyl,     substituted or unsubstituted cycloalkyl, substituted or     unsubstituted cycloalkenyl, a substituted or unsubstituted     non-aromatic heterocyclic group, substituted or unsubstituted aryl,     or substituted or unsubstituted heteroaryl; -   R³ is substituted or unsubstituted alkyl, substituted or     unsubstituted alkenyl, substituted or unsubstituted alkynyl,     substituted or unsubstituted cycloalkyl, substituted or     unsubstituted cycloalkenyl, a substituted or unsubstituted     non-aromatic heterocyclic group, substituted or unsubstituted aryl,     or substituted or unsubstituted heteroaryl; -   R^(4a) and R^(4b) are each independently hydrogen, substituted or     unsubstituted alkyl, or R^(4a) and R^(4b) are taken together oxo: -   —X— is —O—, —S— or —N(R⁵)—: -   R⁵ is hydrogen, substituted or unsubstituted alkyl, or substituted     or unsubstituted acyl; -   provided that R³ is not cyclohexyl substituted with guanidyl when     —X— is —NH—, or its pharmaceutically acceptable salt, or a solvate     thereof.

(1′) A compound represented by the formula (I′):

wherein

-   R^(a), R^(b) and R^(c) are, -   (a) R^(a) and R^(b) are taken together ═Z; and R^(c) is R^(1c); or -   (b) R^(b) and R^(c) are taken together to form a bond; and R^(a) is     —Y—R^(1a); -   R^(1a) and R^(1 c) are each independently hydrogen, substituted or     unsubstituted alkyl, -   substituted or unsubstituted alkenyl, substituted or unsubstituted     alkynyl, -   substituted or unsubstituted acyl, substituted or unsubstituted     cycloalkyl, -   substituted or unsubstituted cycloalkenyl, a substituted or     unsubstituted non-aromatic heterocyclic group, substituted or     unsubstituted aryl, or substituted or unsubstituted heteroaryl; -   n is an integer of 0 to 4; -   R² is hydrogen, substituted or unsubstituted alkyl, substituted or     unsubstituted alkenyl, substituted or unsubstituted alkynyl,     substituted or unsubstituted cycloalkyl, substituted or     unsubstituted cycloalkenyl, a substituted or unsubstituted     non-aromatic heterocyclic group, substituted or unsubstituted aryl,     or substituted or unsubstituted heteroaryl; -   R³ is substituted or unsubstituted alkyl, substituted or     unsubstituted alkenyl, substituted or unsubstituted alkynyl,     substituted or unsubstituted cycloalkyl, substituted or     unsubstituted cycloalkenyl, a substituted or unsubstituted     non-aromatic heterocyclic group, substituted or unsubstituted aryl,     or substituted or unsubstituted heteroaryl; -   R^(4a) and R^(4b) are each independently hydrogen, substituted or     unsubstituted alkyl; -   —X— is —O—, —S— or —N(R⁵)—; -   R⁵ is hydrogen, substituted or unsubstituted alkyl, or substituted     or unsubstituted acyl; -   when R^(a), R^(b) and R^(c) are (a); -   ═Z is ═O, ═S or ═N—R⁶; -   R⁶ is hydrogen, substituted or unsubstituted alkyl, substituted or     unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl,     a substituted or unsubstituted non-aromatic heterocyclic group,     substituted or unsubstituted aryl, or substituted or unsubstituted     heteroaryl; -   when R^(a), R^(b) and R^(c) are (b), -   —Y— is —O—, —S— or —N(R⁷)—; -   R⁷ is hydrogen, substituted or unsubstituted alkyl, or substituted     or unsubstituted acyl; -   provided that R³ is not cyclohexyl substituted with guanidyl when     —X— is —NH—, or its pharmaceutically acceptable salt, or a solvate     thereof.

(1″) A compound represented by the formula (I″):

wherein

-   R^(a), R^(b) and R^(c) are, -   (a) R^(a) and R^(b) are taken together ═Z; and R^(c) is R^(1c); or -   (b) R^(b) and R^(c) are taken together to form a bond; and R^(a) is     —Y—R^(1a); -   R^(1a) and R^(1 c) are each independently hydrogen, substituted or     unsubstituted lower alkyl, substituted or unsubstituted arylalkyl,     substituted or unsubstituted heteroarylalkyl, substituted or     unsubstituted lower alkenyl, substituted or unsubstituted lower     alkynyl, substituted or unsubstituted cycloalkyl, substituted or     unsubstituted cycloalkenyl, substituted or unsubstituted acyl, a     substituted or unsubstituted non-aromatic heterocyclic group,     substituted or unsubstituted aryl, or substituted or unsubstituted     heteroaryl; -   R² is substituted or unsubstituted cycloalkyl, substituted or     unsubstituted cycloalkenyl, a substituted or unsubstituted     non-aromatic heterocyclic group, substituted or unsubstituted aryl,     or substituted or unsubstituted heteroaryl; -   R^(4a) and R^(4b) are each independently hydrogen, or substituted or     unsubstituted lower alkyl; -   —X— is —O—, —S— or —N(R⁵)—; -   R⁵ is hydrogen, or substituted or unsubstituted lower alkyl, or     substituted or unsubstituted acyl; -   when R^(a), R^(b) and R^(c) are (a); -   ═Z is ═O, ═S or ═N—R⁶; -   R⁶ is hydrogen, substituted or unsubstituted lower alkyl,     substituted or unsubstituted arylalkyl, substituted or unsubstituted     heteroarylalkyl, substituted or unsubstituted aryl, or substituted     or unsubstituted heteroaryl; -   R³ is substituted or unsubstituted lower alkenyl, substituted or     unsubstituted lower alkynyl, substituted or unsubstituted     cycloalkenyl, a substituted or unsubstituted non-aromatic     heterocyclic group, substituted or unsubstituted aryl, or     substituted or unsubstituted heteroaryl; -   n is an integer of 1 to 3; -   when R^(a), R^(b) and R^(c) are (b); -   R³ is substituted or unsubstituted lower alkenyl, substituted or     unsubstituted lower alkynyl, substituted or unsubstituted     cycloalkyl, substituted or unsubstituted cycloalkenyl, a substituted     or unsubstituted non-aromatic heterocyclic group, substituted or     unsubstituted aryl, or substituted or unsubstituted heteroaryl; -   —Y— is —O—, —S— or —N(R⁷)—; -   R⁷ is hydrogen, substituted or unsubstituted lower alkyl, or     substituted or unsubstituted acyl; -   n is an integer of 0 to 3, -   or its pharmaceutically acceptable salt, or a solvate thereof.

(2) The compound according to (1), wherein the compound is represented by the formula (II):

wherein

-   R^(1c), R^(4a), R^(4b), —X— and ═Z are as defined in (1); -   n is an integer of 1 to 4; -   R² and R³ are each independently substituted or unsubstituted     cycloalkyl, substituted or unsubstituted cycloalkenyl, a substituted     or unsubstituted non-aromatic heterocyclic group, substituted or     unsubstituted aryl, or substituted or unsubstituted heteroaryl, or     its pharmaceutically acceptable salt, or a solvate thereof.

(2′) The compound according to (1′), wherein the compound is represented by the formula (II′):

wherein

-   R^(1c), R^(4a), R^(4b), —X— and ═Z are as defined in (1); -   n is an integer of 1 to 4; -   R² and R³ are each independently substituted or unsubstituted     cycloalkyl, substituted or unsubstituted cycloalkenyl, a substituted     or unsubstituted non-aromatic heterocyclic group, substituted or     unsubstituted aryl, or substituted or unsubstituted heteroaryl, or     its pharmaceutically acceptable salt, or a solvate thereof.

(2″) The compound according to (1″), wherein the compound is represented by the formula (II″):

wherein

-   R^(1a), R², R³, R^(4a), R^(4b), —X—═Z and n are as defined in (1″),     or its pharmaceutically acceptable salt, or a solvate thereof.

(3) The compound according to the above (1) or (2), wherein —X— is —N(R⁵)— wherein R⁵ is as defined in the above (1), or its pharmaceutically acceptable salt, or a solvate thereof.

(3′) The compound according to the above (2′), wherein —X— is —N(R⁵)— wherein R⁵ is as defined in the above (1′), or its pharmaceutically acceptable salt, or a solvate thereof.

(3″) The compound according to the above (2″), wherein —X— is —N(R⁵)— wherein R⁵ is as defined in the above (1″), or its pharmaceutically acceptable salt, or a solvate thereof.

(4) The compound according to any one of the above (1) to (3), wherein R² is substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl, or its pharmaceutically acceptable salt, or a solvate thereof.

(4′) The compound according to any one of the above (2′) or (3′), wherein R² is substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl, n is 1, or its pharmaceutically acceptable salt, or a solvate thereof.

(4″) The compound according to any one of the above (2″) or (3″), wherein R² is substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl, n is 1, or its pharmaceutically acceptable salt, or a solvate thereof.

(5) The compound according to any one of the above (1) to (4), wherein ═Z is ═O, or its pharmaceutically acceptable salt, or a solvate thereof.

(6) The compound according to any one of the above (1) to (5), wherein R^(1c) is hydrogen; unsubstituted alkyl; or alkyl substituted with one or more substituents selected from Substituent Group A(Substituent Group A:halogen, hydroxy, substituted or unsubstituted alkyloxy, substituted or unsubstituted alkenyloxy, substituted or unsubstituted alkynyloxy, substituted or unsubstituted alkylthio, substituted or unsubstituted alkenylthio, substituted or unsubstituted alkynylthio, substituted or unsubstituted acyl, carboxy, substituted or unsubstituted alkyloxycarbonyl, substituted or unsubstituted alkenyloxycarbonyl, substituted or unsubstituted alkynyloxycarbonyl, substituted or unsubstituted cycloalkyloxycarbonyl, substituted or unsubstituted cycloalkenyloxycarbonyl, substituted or unsubstituted non-aromatic heterocyclic ring-oxy-carbonyl, substituted or unsubstituted aryloxycarbonyl, substituted or unsubstituted heteroaryloxycarbonyl, substituted or unsubstituted carbamoyl, substituted or unsubstituted amino, substituted or unsubstituted sulfamoyl, cyano, nitro, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, a substituted or unsubstituted non-aromatic heterocyclic group, substituted or unsubstituted aryl, and substituted or unsubstituted heteroaryl, or its pharmaceutically acceptable salt, or a solvate thereof.

(6′) The compound according to any one of the above (2′) to (4′), wherein R^(1c) is hydrogen; unsubstituted alkyl; or alkyl substituted with one or more substituents selected from Substituent Group A(Substituent Group A:halogen, hydroxy, substituted or unsubstituted alkyloxy, substituted or unsubstituted alkenyloxy, substituted or unsubstituted alkynyloxy, substituted or unsubstituted alkylthio, substituted or unsubstituted alkenylthio, substituted or unsubstituted alkynylthio, substituted or unsubstituted acyl, carboxy, substituted or unsubstituted alkyloxycarbonyl, substituted or unsubstituted alkenyloxycarbonyl, substituted or unsubstituted alkynyloxycarbonyl, substituted or unsubstituted cycloalkyloxycarbonyl, substituted or unsubstituted cycloalkenyloxycarbonyl, substituted or unsubstituted non-aromatic heterocyclic ring-oxy-carbonyl, substituted or unsubstituted aryloxycarbonyl, substituted or unsubstituted heteroaryloxycarbonyl, substituted or unsubstituted carbamoyl, substituted or unsubstituted amino, substituted or unsubstituted sulfamoyl, cyano, nitro, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, a substituted or unsubstituted non-aromatic heterocyclic group, substituted or unsubstituted aryl, and substituted or unsubstituted heteroaryl, or its pharmaceutically acceptable salt, or a solvate thereof.

(6″) The compound according to any one of the above (2″) to (4″), wherein R^(1a) is hydrogen; unsubstituted alkyl; or alkyl substituted with one or two or more substituent selected from halogen, hydroxy, substituted or unsubstituted lower alkenyl, substituted or unsubstituted lower alkynyl, substituted or unsubstituted lower alkyloxy, substituted or unsubstituted lower alkylthio, substituted or unsubstituted acyl, carboxy, substituted or unsubstituted lower alkyloxycarbonyl, substituted or unsubstituted benzoyl, substituted or unsubstituted carbamoyl, substituted or unsubstituted lower alkylcarbamoyl, substituted or unsubstituted amino, substituted or unsubstituted sulfamoyl, cyano, nitro, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, a substituted or unsubstituted non-aromatic heterocyclic group, substituted or unsubstituted aryl, and substituted or unsubstituted heteroaryl, or its pharmaceutically acceptable salt, or a solvate thereof.

(7) The compound according to any one of the above (1) to (6), wherein R³ is a group represented by the formula:

wherein ring A is aryl or heteroaryl:

-   s is an integer of 0 to 3; and -   R⁹ is each independently halogen, hydroxy, cyano, nitro, substituted     or unsubstituted alkyl, substituted or unsubstituted alkenyl,     substituted or unsubstituted alkynyl, substituted or unsubstituted     alkyloxy, substituted or unsubstituted alkenyloxy, substituted or     unsubstituted alkynyloxy, substituted or unsubstituted alkylthio,     substituted or unsubstituted alkenylthio, substituted or     unsubstituted alkynylthio, substituted or unsubstituted acyl,     carboxy, substituted or unsubstituted alkyloxycarbonyl, substituted     or unsubstituted alkenyloxycarbonyl, substituted or unsubstituted     alkynyloxycarbonyl, substituted or unsubstituted carbamoyl,     substituted or unsubstituted amino, substituted or unsubstituted     sulfamoyl, substituted or unsubstituted cycloalkyl, substituted or     unsubstituted cycloalkenyl, a substituted or unsubstituted     non-aromatic heterocyclic group, substituted or unsubstituted aryl,     substituted or unsubstituted heteroaryl, substituted or     unsubstituted cycloalkyloxy, substituted or unsubstituted     cycloalkenyloxy, substituted or unsubstituted non-aromatic     heterocyclic ring-oxy, substituted or unsubstituted aryloxy, or     substituted or unsubstituted heteroaryloxy, or its pharmaceutically     acceptable salt, or a solvate thereof.

(7′) The compound according to any one of the above (2′) to (4′) or (6′), wherein R³ is a group represented by the formula:

wherein ring A is aryl or heteroaryl;

-   s is an integer of 0 to 3; -   R⁹ is each independently halogen, hydroxy, cyano, nitro, substituted     or unsubstituted alkyl, substituted or unsubstituted alkenyl,     substituted or unsubstituted alkynyl, substituted or unsubstituted     alkyloxy, substituted or unsubstituted alkenyloxy, substituted or     unsubstituted alkynyloxy, substituted or unsubstituted alkylthio,     substituted or unsubstituted alkenylthio, substituted or     unsubstituted alkynylthio, substituted or unsubstituted acyl,     carboxy, substituted or unsubstituted alkyloxycarbonyl, substituted     or unsubstituted alkenyloxycarbonyl, substituted or unsubstituted     alkynyloxycarbonyl, substituted or unsubstituted carbamoyl,     substituted or unsubstituted amino, substituted or unsubstituted     sulfamoyl, substituted or unsubstituted cycloalkyl, substituted or     unsubstituted cycloalkenyl, a substituted or unsubstituted     non-aromatic heterocyclic group, substituted or unsubstituted aryl,     substituted or unsubstituted heteroaryl, substituted or     unsubstituted cycloalkyloxy, substituted or unsubstituted     cycloalkenyloxy, substituted or unsubstituted non-aromatic     heterocyclic ring-oxy, substituted or unsubstituted aryloxy, or     substituted or unsubstituted heteroaryloxy, or its pharmaceutically     acceptable salt, or a solvate thereof.

(7″) The compound according to any one of the above (2″) to (4″) or (6″), wherein R³ is a group represented by the formula:

wherein ring A is aryl or heteroaryl;

-   s is an integer of 0 to 3; -   R⁹ is each independently halogen, hydroxy, substituted or     unsubstituted alkyl, substituted or unsubstituted alkyloxy,     substituted or unsubstituted lower alkenyl, substituted or     unsubstituted lower alkenyloxy, substituted or unsubstituted lower     alkynyl, substituted or unsubstituted alkynyloxy, substituted or     unsubstituted lower alkylthio, substituted or unsubstituted acyl,     carboxy, substituted or unsubstituted lower alkyloxycarbonyl,     substituted or unsubstituted carbamoyl, substituted or unsubstituted     lower alkylcarbamoyl, substituted or unsubstituted amino,     substituted or unsubstituted sulfamoyl, cyano, nitro, nitrile,     substituted or unsubstituted cycloalkyl, substituted or     unsubstituted cycloalkyloxy, substituted or unsubstituted     cycloalkenyl, substituted or unsubstituted cycloalkenyloxy, a     substituted or unsubstituted non-aromatic heterocyclic group,     substituted or unsubstituted non-aromatic heterocyclic ring-oxy,     substituted or unsubstituted aryl, substituted or unsubstituted     aryloxy, substituted or unsubstituted heteroaryl, or substituted or     unsubstituted heteroaryloxy, or its pharmaceutically acceptable     salt, or a solvate thereof.

(8) The compound according to any one of the above (1) to (7), wherein R³ is a group represented by the formula:

wherein R^(9a) and R^(9b) are each independently halogen, hydroxy, cyano, nitro, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted alkyloxy, substituted or unsubstituted alkenyloxy, substituted or unsubstituted alkynyloxy, substituted or unsubstituted alkylthio, substituted or unsubstituted alkenylthio, substituted or unsubstituted alkynylthio, substituted or unsubstituted acyl, carboxy, substituted or unsubstituted alkyloxycarbonyl, substituted or unsubstituted alkenyloxycarbonyl, substituted or unsubstituted alkynyloxycarbonyl, substituted or unsubstituted carbamoyl, substituted or unsubstituted amino, substituted or unsubstituted sulfamoyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, a substituted or unsubstituted non-aromatic heterocyclic group, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted cycloalkyloxy, substituted or unsubstituted cycloalkenyloxy, substituted or unsubstituted non-aromatic heterocyclic ring-oxy, substituted or unsubstituted aryloxy, or substituted or unsubstituted heteroaryloxy, or its pharmaceutically acceptable salt, or a solvate thereof.

(8′) The compound according to any one of the above (2′) to (4′), (6′) or (7′), wherein R³ is a group represented by the formula:

wherein R^(9a) and R^(9b) are each independently halogen, hydroxy, cyano, nitro, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted alkyloxy, substituted or unsubstituted alkenyloxy, substituted or unsubstituted alkynyloxy, substituted or unsubstituted alkylthio, substituted or unsubstituted alkenylthio, substituted or unsubstituted alkynylthio, substituted or unsubstituted acyl, carboxy, substituted or unsubstituted alkyloxycarbonyl, substituted or unsubstituted alkenyloxycarbonyl, substituted or unsubstituted alkynyloxycarbonyl, substituted or unsubstituted carbamoyl, substituted or unsubstituted amino, substituted or unsubstituted sulfamoyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, a substituted or unsubstituted non-aromatic heterocyclic group, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted cycloalkyloxy, substituted or unsubstituted cycloalkenyloxy, substituted or unsubstituted non-aromatic heterocyclic ring-oxy, substituted or unsubstituted aryloxy, or substituted or unsubstituted heteroaryloxy, or its pharmaceutically acceptable salt, or a solvate thereof.

(8″) The compound according to any one of the above (2″) to (4″), (6″) or (7″), wherein R³ is a group represented by the formula:

wherein R^(9a) and R^(9b) are each independently halogen, hydroxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkyloxy, substituted or unsubstituted lower alkenyl, substituted or unsubstituted lower alkenyloxy, substituted or unsubstituted lower alkynyl, substituted or unsubstituted alkynyloxy, substituted or unsubstituted lower alkylthio, substituted or unsubstituted acyl, carboxy, substituted or unsubstituted lower alkyloxycarbonyl, substituted or unsubstituted carbamoyl, substituted or unsubstituted lower alkylcarbamoyl, substituted or unsubstituted amino, substituted or unsubstituted sulfamoyl, cyano, nitro, nitrile, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkyloxy, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted cycloalkenyloxy, a substituted or unsubstituted non-aromatic heterocyclic group, substituted or unsubstituted non-aromatic heterocyclic ring-oxy, substituted or unsubstituted aryl, substituted or unsubstituted aryloxy, substituted or unsubstituted heteroaryl, or substituted or unsubstituted heteroaryloxy, or its pharmaceutically acceptable salt, or a solvate thereof.

(9) The compound according to any one of the above (1) to (8), wherein R³ is a group represented by the formula:

wherein R⁹ is as defined in the above (7); and R¹⁰ is substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, a substituted or unsubstituted non-aromatic heterocyclic group, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl, or its pharmaceutically acceptable salt, or a solvate thereof.

(9′) The compound according to any one of the above (2′) to (4′) or (6′) to (8′), wherein R³ is a group represented by the formula:

wherein R⁹ is as defined in the above (7′); and R¹⁰ is substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, a substituted or unsubstituted non-aromatic heterocyclic group, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl, or its pharmaceutically acceptable salt, or a solvate thereof.

(9″) The compound according to any one of the above (2″) to (4″) or (6″) to (8″), R³ is a group represented by the formula:

wherein R⁹ is as defined in the above (7″); and R¹⁰ is substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, a substituted or unsubstituted non-aromatic heterocyclic group, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl, or its pharmaceutically acceptable salt, or a solvate thereof.

(10) The compound according to the above (1), wherein the compound is represented by the formula (III):

wherein R^(1a), R^(4a), R^(4b), —X— and —Y— are as defined in the above (1);

-   n is an integer of 1 to 4; and -   R² and R³ are each independently substituted or unsubstituted     cycloalkyl, substituted or unsubstituted cycloalkenyl, a substituted     or unsubstituted non-aromatic heterocyclic group, substituted or     unsubstituted aryl, or substituted or unsubstituted heteroaryl, or     its pharmaceutically acceptable salt, or a solvate thereof.

(10′) The compound according to the above (1′), wherein the compound is represented by the formula (III′):

wherein R^(1a), R^(4a), R^(4b), —X—, —Y— and n are as defined in the above (1′);

-   R² and R³ are each independently substituted or unsubstituted     cycloalkyl, substituted or unsubstituted cycloalkenyl, a substituted     or unsubstituted non-aromatic heterocyclic group, substituted or     unsubstituted aryl, or substituted or unsubstituted heteroaryl, or     its pharmaceutically acceptable salt, or a solvate thereof.

(10″) The compound according to the above (1″), wherein the compound is represented by the formula (III″):

wherein R^(1b), R², R³, R^(4a), R^(4b), —X—, —Y— and n are as defined in the above (1″), or its pharmaceutically acceptable salt, or a solvate thereof.

(11) The compound according to the above (1) or (10), wherein —X— is —N(R⁵)— wherein R⁵ is as defined in the above (1), or its pharmaceutically acceptable salt, or a solvate thereof.

(11′) The compound according to the above (10′), wherein —X— is —N(R⁵)— wherein R⁵ is as defined in the above (1′), or its pharmaceutically acceptable salt, or a solvate thereof.

(11″) The compound according to the above (10′), wherein —X— is —N(R⁵)— wherein R⁵ is as defined in the above (1″), or its pharmaceutically acceptable salt, or a solvate thereof.

(12) The compound according to any one of the above (1), (10) or (11), wherein R² is substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl, or its pharmaceutically acceptable salt, or a solvate thereof.

(12′) The compound according to the above (10′) or (11′), wherein R² is substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl, and n is 1, or its pharmaceutically acceptable salt, or a solvate thereof.

(12″) The compound according to the above (10′) or (11′), wherein R² is substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl, and n is 1, or its pharmaceutically acceptable salt, or a solvate thereof.

(13) The compound according to any one of the above (1) or (10) to (12), wherein —Y— is —O—, or its pharmaceutically acceptable salt, or a solvate thereof.

(13′) The compound according to the above (10′) or (11′), wherein —Y— is —O—, or its pharmaceutically acceptable salt, or a solvate thereof.

(13″) The compound according to the above (10″) or (11″), wherein —Y— is —O—, or its pharmaceutically acceptable salt, or a solvate thereof.

(14) The compound according to any one of the above (1) or (10) to (13), wherein R^(1a) is hydrogen; unsubstituted alkyl; or alkyl substituted with one or more substituents selected from Substituent Group A (Substituent Group A: halogen, hydroxy, substituted or unsubstituted alkyloxy, substituted or unsubstituted alkenyloxy, substituted or unsubstituted alkynyloxy, substituted or unsubstituted alkylthio, substituted or unsubstituted alkenylthio, substituted or unsubstituted alkynylthio, substituted or unsubstituted acyl, carboxy, substituted or unsubstituted alkyloxycarbonyl, substituted or unsubstituted alkenyloxycarbonyl, substituted or unsubstituted alkynyloxycarbonyl, substituted or unsubstituted cycloalkyloxycarbonyl, substituted or unsubstituted cycloalkenyloxycarbonyl, substituted or unsubstituted non-aromatic heterocyclic ring-oxy-carbonyl, substituted or unsubstituted aryloxycarbonyl, substituted or unsubstituted heteroaryloxycarbonyl, substituted or unsubstituted carbamoyl, substituted or unsubstituted amino, substituted or unsubstituted sulfamoyl, cyano, nitro, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, a substituted or unsubstituted non-aromatic heterocyclic group, substituted or unsubstituted aryl, and substituted or unsubstituted heteroaryl), or its pharmaceutically acceptable salt, or a solvate thereof.

(14′) The compound according to any one of the above (10″) to (13″), wherein R^(1a) is hydrogen; unsubstituted alkyl; or alkyl substituted with one or more substituents selected from Substituent Group A (Substituent Group A: halogen, hydroxy, substituted or unsubstituted alkyloxy, substituted or unsubstituted alkenyloxy, substituted or unsubstituted alkynyloxy, substituted or unsubstituted alkylthio, substituted or unsubstituted alkenylthio, substituted or unsubstituted alkynylthio, substituted or unsubstituted acyl, carboxy, substituted or unsubstituted alkyloxycarbonyl, substituted or unsubstituted alkenyloxycarbonyl, substituted or unsubstituted alkynyloxycarbonyl, substituted or unsubstituted cycloalkyloxycarbonyl, substituted or unsubstituted cycloalkenyloxycarbonyl, substituted or unsubstituted non-aromatic heterocyclic ring-oxy-carbonyl, substituted or unsubstituted aryloxycarbonyl, substituted or unsubstituted heteroaryloxycarbonyl, substituted or unsubstituted carbamoyl, substituted or unsubstituted amino, substituted or unsubstituted sulfamoyl, cyano, nitro, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, a substituted or unsubstituted non-aromatic heterocyclic group, substituted or unsubstituted aryl and substituted or unsubstituted heteroaryl), or its pharmaceutically acceptable salt, or a solvate thereof.

(14″) The compound according to any one of the above (10″) to (13″), wherein R^(1b) is hydrogen; unsubstituted alkyl; or alkyl substituted with one or two or more substituent selected from halogen, hydroxy, substituted or unsubstituted lower alkenyl, substituted or unsubstituted lower alkynyl, substituted or unsubstituted lower alkyloxy, substituted or unsubstituted lower alkylthio, substituted or unsubstituted acyl, carboxy, substituted or unsubstituted lower alkyloxycarbonyl, substituted or unsubstituted benzoyl, substituted or unsubstituted carbamoyl, substituted or unsubstituted lower alkylcarbamoyl, substituted or unsubstituted amino, substituted or unsubstituted sulfamoyl, cyano, nitro, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, a substituted or unsubstituted non-aromatic heterocyclic group, substituted or unsubstituted aryl and substituted or unsubstituted heteroaryl, or its pharmaceutically acceptable salt, or a solvate thereof.

(15) The compound according to any one of the above (1) or (10) to (14), wherein R³ is a group represented by the formula:

wherein ring A is aryl or heteroaryl;

-   s is an integer of 0 to 3; and -   R⁹ is as defined in the above (7), or its pharmaceutically     acceptable salt, or a solvate thereof.

(15′) The compound according to any one of the above (10′) to (14′), wherein R³ is a group represented by the formula:

wherein ring A is aryl or heteroaryl;

-   s is an integer of 0 to 3; and -   R⁹ is as defined in the above (7′), or its pharmaceutically     acceptable salt, or a solvate thereof.

(15″) The compound according to any one of the above (10″) to (13″), wherein R³ is a group represented by the formula:

wherein ring A is aryl or heteroaryl:

-   s is an integer of 0 to 3; and -   R⁹ is as defined in the above (7″), or its pharmaceutically     acceptable salt, or a solvate thereof.

(16) The compound according to any one of the above (1) or (10) to (15), wherein R³ is a group represented by the formula:

wherein R^(9a) and R^(9b) are as defined in the above (8), or its pharmaceutically acceptable salt, or a solvate thereof.

(16′) The compound according to any one of the above (10′) to (15′), wherein R³ is a group represented by the formula:

wherein R^(9a) and R^(9b) are as defined in the above (8′), or its pharmaceutically acceptable salt, or a solvate thereof.

(16″) The compound according to any one of the above (10″) to (15″), wherein R³ is a group represented by the formula:

wherein R^(9a) and R^(9b) are as defined in the above (8″), or its pharmaceutically acceptable salt, or a solvate thereof.

(17) The compound according to any one of the above (1) or (10) to (16), wherein R³ is a group represented by the formula:

wherein R⁹ is as defined in the above (7); and R¹⁰ is as defined in the above (9), or its pharmaceutically acceptable salt, or a solvate thereof.

(17′) The compound according to any one of the above (10′) to (16′), wherein R³ is a group represented by the formula:

wherein R⁹ is as defined in the above (7′); and R¹⁰ is as defined in the above (9′), or its pharmaceutically acceptable salt, or a solvate thereof.

(17″) The compound according to any one of the above (10″) to (16″), wherein R³ is a group represented by the formula:

wherein R⁹ is as defined in the above (7″); and R¹⁰ is as defined in the above (9″), or its pharmaceutically acceptable salt, or a solvate thereof.

(18) A pharmaceutical composition comprising the compound according to any one of the above (1) to (17), or its pharmaceutically acceptable salt, or a solvate thereof.

(18′) A pharmaceutical composition comprising the compound according to any one of the above (1′) to (4′) or (6′) to (17′), or its pharmaceutically acceptable salt, or a solvate thereof.

(18″) A pharmaceutical composition comprising the compound according to any one of the above (1″) to (4″) or (6″) to (17″), or its pharmaceutically acceptable salt, or a solvate thereof.

(19) The pharmaceutical composition according to the above (18), wherein the composition is for a P2X₃ and/or P2X_(2/3) receptor antagonist.

(19′) The pharmaceutical composition according to the above (18′), wherein the composition is for a P2X₃ and/or P2X_(2/3) receptor antagonist.

(19″) The pharmaceutical composition according to the above (18″), wherein the composition is for a P2X₃ and/or P2X_(2/3) receptor antagonist.

(20) A method for treating and/or preventing a disease related to P2X₃ and/or P2X_(2/3) receptor characterized by administration of the compound according to any one of the above (1) to (17), or its pharmaceutically acceptable salt, or a solvate thereof.

(20′) A method for preventing and/or treating a disease related to P2X₃ and/or P2X_(2/3) receptor characterized by administration of the compound according to any one of the above (1′) to (4′) or (6′) to (17′), or its pharmaceutically acceptable salt, or a solvate thereof.

(20″) A method for preventing and/or treating a disease related to P2X₃ and/or P2X_(2/3) receptor characterized by administration of the compound according to any one of the above (1′) to (4′) or (6′) to (17′), or its pharmaceutically acceptable salt, or a solvate thereof.

(21) Use of the compound of any one of the above (1) to (17), or its pharmaceutically acceptable salt, or a solvate thereof in the manufacturing of an agent for treating and/or preventing a disease related to P2X₃ and/or P2X_(2/3) receptor.

(21′) Use of the compound of any one of the above (1′) to (4′) or (6′) to (17′), or its pharmaceutically acceptable salt, or a solvate thereof in the manufacturing of an agent for treating and/or preventing a disease related to P2X₃ and/or P2X_(2/3) receptor.

(21″) Use of the compound of any one of the above (1″) to (4″) or (6″) to (17″), or its pharmaceutically acceptable salt, or a solvate thereof in the manufacturing of an agent for treating and/or preventing a disease related to P2X₃ and/or P2X_(2/3) receptor.

(22) A compound according to any one of the above (1) to (17), or its pharmaceutically acceptable salt, or a solvate thereof for use in a method for treating and/or preventing a disease related to P2X₃ and/or P2X_(2/3) receptor.

As used throughout the specification, the following terms have the following meaning unless specifically indicated.

The term “halogen” means fluorine, chlorine, bromine and iodine.

The halogen moiety in said “lower haloalkyl”, “lower haloalkyloxy”, “haloalkyl” and “haloalkyloxy” is as defined above for “halogen”.

The term “alkyl” includes a straight or branched chain monovalent hydrocarbon group containing from 1 to 15, preferably from 1 to 10 more preferably from 1 to 6 carbons. For example, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, n-pentyl, isopentyl, neo-pentyl, n-hexyl, isohexyl, n-heptyl, isoheptyl, n-octyl, isooctyl, n-nonyl, n-decyl, n-undecanyl, dodecanyl, tridecanyl, etc. are exemplified.

The term “lower alkyl” includes a straight or branched chain monovalent hydrocarbon group containing from 1 to 6, preferably from 1 to 3 carbons. For example, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, n-pentyl, isopentyl, neo-pentyl, n-hexyl, isohexyl, etc. are exemplified.

The lower alkyl moiety in said “lower haloalkyl”, “lower alkylamino”, “lower alkylimino”, “lower alkylsulfonyl”, “lower alkylsulfamoyl” and “lower alkylcarbamoyl” is as defined above for “lower alkyl”.

The alkyl moiety in said “haloalkyl”, “alkylamino”, “alkylimino”, “alkylsulfonyl”, “alkylsulfamoyl”, “alkylcarbamoyl”, “arylalkyl” and “arylalkylamino” is as defined above for “alkyl”.

The term “lower alkyloxy” includes an alkyloxy group wherein the lower alkyl moiety is as defined above for “lower alkyl”. For example, methoxy, ethoxy, propoxy, isopropoxy, butoxy, isobutoxy, sec-butoxy, tert-butoxy, pentoxy, isopentoxy, neopentoxy, hexoxy, etc. are exemplified.

The alkyl moiety in said “alkyloxy” is as defined above for “alkyl”.

The lower alkyloxy moiety in said “lower haloalkyloxy” and “lower alkyloxyimino” is as defined above for “lower alkyloxy”.

The term “lower alkylthio” includes, for example, methylthio, ethylthio, propylthio, isopropylthio, butylthio, isobutylthio, sec-butylthio, tert-butylthio, pentylthio, isopentylthio, neopentylthio, hexylthio, etc.

The alkyl moiety in said “alkylthio” is as defined above for “alkyl”.

The term “lower alkyloxycarbonyl” includes, for example, methyloxycarbonyl, ethyloxycarbonyl, n-propyloxycarbonyl, isopropyloxycarbonyl, n-butyloxycarbonyl, tert-butyloxycarbonyl, n-pentyloxycarbonyl, etc.

The alkyloxy moiety in said “alkyloxycarbonyl” is as defined above for “alkyloxy”.

The term “lower alkylcarbamoyl” includes mono- or di-lower alkylcarbamoyl. For example, methylcarbamoyl, ethylcarbamoyl, n-propylcarbamoyl, isopropylcarbamoyl, n-butylcarbamoyl, dimethylcarbamoyl, diethylcarbamoyl, dipropylcarbamoyl, etc. are exemplified.

The alkyl moiety in said “alkylcarbamoyl” is as defined above for “alkyl”.

The term “alkenyl” includes a straight or branched chain alkenyl containing from 2 to 15 carbons, preferably containing from 2 to 10 carbons, more preferably containing from 2 to 6 carbons having one or more double bonds at any position. For example, vinyl, propenyl, isopropenyl, butenyl, isobutenyl, prenyl, butadienyl, pentenyl, isopentenyl, pentadienyl, hexenyl, isohexenyl, hexadienyl, heptenyl, octenyl, nonenyl, decenyl, undecenyl, dodecenyl, tridecenyl, etc. are exemplified.

The term “lower alkenyl” includes a straight or branched chain alkenyl containing from 2 to 6 carbons, preferably containing from 2 to 3 carbons having one or more double bonds at any position. For example, vinyl, propenyl, isopropenyl, butenyl, isobutenyl, prenyl, butadienyl, pentenyl, isopentenyl, pentadienyl, hexenyl, isohexenyl, hexadienyl, etc. are exemplified.

The lower alkenyl moiety of “lower alkenyloxy” and “lower alkenyloxycarbonyl” is as defined above for “lower alkenyl”.

The alkenyl moiety of “alkenyloxy” and “alkenyloxycarbonyl” is as defined above for “alkenyl”.

The term “alkynyl” includes a straight or branched chain alkynyl containing from 2 to 15 carbons, preferably containing from 2 to 10 carbons, more preferably containing from 2 to 6 carbons. For example, ethynyl, propynyl, butynyl, pentynyl, hexynyl, heptynyl, octynyl, nonynyl, decynyl, etc. are exemplified. They have one or more triple bonds at any position, and optionally, have a double bond.

The term “lower alkynyl” includes a straight or branched chain alkynyl containing from 2 to 6 carbons, preferably containing from 2 to 3 carbons. For example, ethynyl, propynyl, butynyl, pentynyl, hexynyl, etc. are exemplified. They have one or more triple bonds at any position, and optionally, have a double bond.

The lower alkynyl moiety of “lower alkynyloxy” and “lower alkynyloxycarbonyl” is as defined above for “lower alkynyl”.

The alkynyl moiety of “alkynyloxy” and “alkynyloxycarbonyl” is as defined above for “alkynyl”.

The term “acyl” includes a group of the formula R—C(═O)—, wherein R is, for example, “lower alkyl”, “alkyl”, “lower alkenyl”, “alkenyl”, “lower alkynyl”, “alkynyl” as defined above or “aryl”, “a heterocyclic group”, “cycloalkyl”, “cycloalkenyl”, “arylalkyl” or “heteroarylalkyl” as defined bellow.

The acyl moiety of “acylamino” and “acylimino” is as defined above for “acyl”.

The term “cycloalkane” includes a monocyclic or polycyclic saturated cyclic carbocyclic ring containing from 3 to 10 carbons. Monocyclic cycloalkane includes, for example, cyclopropane, cyclobutane, cyclopentane, cyclohexane, cycloheptane, cyclooctane, cyclononane, cyclodecane, etc. Polycyclic cycloalkane includes norbornanane, tetrahydronaphthalene, etc.

The term “cycloalkyl” includes a monovalent group derived from “cycloalkane” as defined above. Monocyclic cycloalkyl includes, for example, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, cyclononyl, cyclodecyl, etc. Polycyclic cycloalkyl includes norbornanyl, tetrahydronaphthalene-5-yl, tetrahydronaphthalene-6-yl, etc.

Preferable “cycloalkyl” for R² is cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, etc.

The cycloalkyl moiety of “cycloalkyloxycarbonyl” is as defined above for “cycloalkyl”.

The term “cycloalkane-diyl” includes a divalent group derived from “cycloalkane” as defined above. Monocyclic cycloalkane-diyl includes, for example, cyclopropane-diyl, cyclobutane-diyl, cyclopentane-diyl, cyclohexane-diyl, cycloheptane-diyl, cyclooctane-diyl, cyclonone-diyl, cyclodecane-diyl, etc. Polycyclic cycloalkane-diyl includes norbornane-diyl, etc.

The term “cycloalkene” includes a non-aromatic monocyclic or polycyclic ring of 3 to 10 carbons containing at least one carbon-carbon double bond. Monocyclic cycloalkene includes, for example, cyclopentene, cyclohexene, etc. Polycyclic cycloalkene includes norborne, indene, etc.

The term “cycloalkenyl” includes a monovalent group derived from “cycloalkene” as defined above. Monocyclic cycloalkenyl includes cyclopentenyl, cyclohexenyl, etc. Polycyclic cycloalkenyl includes norbornyl, indene-1-yl, indene-2-yl, indene-3-yl, etc.

The cycloalkenyl moiety of “cycloalkenyloxycarbonyl” is as defined above for “cycloalkenyl”.

The term “cycloalkene-diyl” includes a divalent group derived from “cycloalkene” as defined above. Monocyclic cycloalkene-diyl includes cyclopentene-diyl, cyclohexene-diyl, etc. Polycyclic cycloalkene-diyl includes norbornene-diyl, etc.

The term “aromatic carbocyclic ring” includes an aromatic hydrocarbocyclic ring which is monocyclic or fused-cyclic. For example, benzene ring, naphthalene ring, anthracene ring, phenanthrene ring, etc. are exemplified.

The term “aryl” includes a monovalent group derived from “aromatic carbocyclic ring” as defined above. For example, phenyl, 1-naphthyl, 2-naphthyl, anthryl, phenanthryl, etc. are exemplified.

The aryl moiety of “aryloxycarbonyl” is as defined above for “aryl”.

The term “aromatic carbocyclic ring-diyl” includes a divalent group derived from “aromatic carbocyclic ring” as defined above. For example, 1,2-phenylene, 1,3-phenylene, 1,4-phenylene, 1,2-naphthalene etc.

The term “heterocyclic ring” includes an aromatic or a non-aromatic monocyclic or fused-cyclic ring, which includes a five- to seven-membered ring having at least one nitrogen atom, oxygen atom, and/or sulphur atom in the ring; a fused ring consisting of two or more said five- to seven-membered rings; or a fused ring consisting of said five- to seven-membered ring having at least one nitrogen atom, oxygen atom, and/or sulphur atom in the ring fused to one or more “aromatic carbocyclic ring”, “cycloalkane” or “cycloalkene” as defined above.

For example, a non-aromatic heterocyclic ring such as pyrroline, pyrrolidine, piperidine, piperazine, morpholine, thiomorpholine, tetrahydropyrane, dihydropyridine, dihydropyridazine, dioxane, oxathiolane, thiane, tetrahydrofuran, tetrahydropyran, tetrahydrothiazole, tetrahydroisothiazole, etc.;

a monocyclic aromatic heterocyclic ring such as pyrrole, pyrazine, pyrazole, tetrazole, furan, thiophene, pyridine, imidazole, triazole, tetrazole, triazine, pyridazine, pyrimidine, isoxazole, thiazole, isothiazole, thiadiazole, oxazole, oxadiazole, etc; and

a fused heterocyclic ring such as indole, isoindole, indazole, indolizine, indoline, isoindoline, quinoline, isoquinoline, cinnoline, phthalazine, quinazoline, naphthyridine, quinoxaline, purine, pteridine, benzopyrane, benzimidazole, benzisoxazole, benzoxazole, benzoxadiazole, benzisothiazole, benzothiazole, benzothiadiazole, benzofuran, isobenzofuran, benzothiophene, benzotriazole, imidazopyridine, triazolopyridine, imidazothiazole, pyrazinopyridazine, benzimidazole, benzodioxane, tetrahydroquinoline, tetrahydrobenzothiophene, etc. are exemplified.

The term “heterocyclic group” includes a monovalent group derived from “heterocyclic ring” as defined above. For example, non-aromatic heterocyclic groups such as pyrrolinyl, pyrrolidino, pyrrolidinyl, imidazolynyl, imidazolidinyl, pyrazolinyl, pyrazolidinyl, piperidino, piperidyl, piperadino, piperazinyl, morpholinyl, morpholino, thiomorpholinyl, thiomorpholino, tetrahydropyranyl, dihydropyridyl, dihydropyridazinyl, dihydropyrazinyl, dioxanyl, oxathiolanyl, thianyl, tetrahydrofuryl, tetrahydropyranyl, tetrahydrothiazolinyl, tetrahydroisothiazolinyl, etc.;

monocyclic aromatic heterocyclic groups such as pyrrolyl, pyrazinyl, pyrazolyl, tetrazolyl, furyl, thienyl, pyridyl, imidazolyl, triazolyl, tetrazolyl, triazinyl, pyridazinyl, pyrimidinyl, pyrazinyl, isoxazolyl, thiazolyl, isothiazolyl, thiadiazolyl, oxazolyl and oxadiazolyl, etc; and

fused heterocyclic groups such as indolyl, isoindolyl, indazolyl, indolizinyl, indolinyl, isoindolinyl, quinolyl, isoquinolyl, cinnolinyl, phthalazinyl, quinazolinyl, naphthyridinyl, quinoxalinyl, purinyl, pteridinyl, benzopyranyl, benzimidazolyl, benzisoxazolyl, benzoxazolyl, benzoxadiazolyl, benzisothiazolyl, benzothiazolyl, benzothiadiazolyl, benzofuryl, isobenzofuryl, benzothienyl, benzotriazolyl, imidazopyridyl, triazolopyridyl, imidazothiazolyl, pyrazinopyridazinyl, benzimidazolynyl, benzodioxanyl, tetrahydroquinoline, tetrahydrobenzothienyl, etc. are exemplified.

The term “heterocyclic ring-diyl” includes a divalent group derived from “heterocyclic ring” as defined above. For example, non-aromatic heterocyclic ring-diyl such as pyrrolin-diyl, pyrrolidin-diyl, imidazolidin-diyl, pyrazolin-diyl, pyrazolidin-diyl, piperidin-diyl, piperazine-diyl, morpholin-diyl, thiomorpholin-diyl, tetrahydropyran-diyl, dihydropyridine-diyl, dihydropyridazin-diyl, dihydropyrazin-diyl, dioxan-diyl, oxathiolan-diyl, thian-diyl, tetrahydrofuran-diyl, tetrahydropyran-diyl, tetrahydrothiazol-diyl, tetrahydroisothiazol-diyl, etc.;

a monocyclic aromatic heterocyclic ring-diyl such as pyrrole-diyl, pyrazine-diyl, pyrazole-diyl, tetrazole-diyl, furan-diyl, thiophene-diyl, pyridine-diyl, imidazole-diyl, triazole-diyl, tetrazole-diyl, triazine-diyl, pyridazine-diyl, pyrimidine-diyl, pyrazine-diyl, isoxazole-diyl, thiazole-diyl, isothiazole-diyl, thiadiazole-diyl, oxazole-diyl, oxadiazole-diyl, etc; and

a fused heterocyclic ring-diyl such as indole-diyl, isoindole-diyl, indazole-diyl, indolizine-diyl, indoline-diyl, isoindoline-diyl, quinoline-diyl, isoquinoline-diyl, cinnoline-diyl, phthalazine-diyl, quinazoline-diyl, naphthyridine-diyl, quinoxaline-diyl, purine-diyl, pteridine-diyl, benzopyrane-diyl, benzimidazole-diyl, benzisoxazole-diyl, benzoxazole-diyl, benzoxadiazole-diyl, benzisothiazole-diyl, benzothiazole-diyl, benzothiadiazole-diyl, benzofuran-diyl, isobenzofuran-diyl, benzothiophene-diyl, benzotriazole-diyl, imidazopyridine-diyl, triazolopyridine-diyl, imidazothiazole-diyl, pyrazinopyridazine-diyl, benzimidazole-diyl, benzodioxane-diyl, tetrahydroquinoline-diyl, tetrahydrobenzothiophene-diyl, etc. are exemplified.

The term “non-aromatic carbocyclic ring” includes “cycloalkane” as defined above, “cycloalkene” as defined above a fused ring consisting of “aromatic carbocyclic ring” as defined above fused to “cycloalkane” as defined above, and a fused ring consisting of “aromatic carbocyclic ring” as defined above fused to “cycloalkene” as defined above. As a fused ring, indene, etc are exemplified.

The term “aromatic heterocyclic ring” includes aromatic rings of “heterocyclic ring” as defined above. “Aromatic heterocyclic ring” includes a five- to seven-membered aromatic ring having at least one nitrogen atom, oxygen atom, and/or sulphur atom in the ring; a fused aromatic ring consisting of two or more said rings; and a fused ring consisting of a five- to seven-membered aromatic ring having at least one nitrogen atom, oxygen atom, and/or sulphur atom in the ring fused to one or more “aromatic carbocyclic ring” as defined above.

For example, a monocyclic aromatic heterocyclic ring such as pyrazine, pyrazole, tetrazole, furan, thiophene, pyridine, imidazole, triazole, triazine, pyridazine, pyrimidine, pyrazine, isoxazole, thiazole, isothiazole, thiadiazole, oxazole, oxadiazole, etc; and

a fused aromatic heterocyclic ring such as indole, isoindole, indazole, indolizine, quinoline, isoquinoline, cinnoline, phthalazine, quinazoline, naphthyridine, quinoxaline, purine, pteridine, benzimidazole, benzisoxazole, benzoxazole, benzoxadiazole, benzisothiazole, benzothiazole, benzothiadiazole, benzofuran, isobenzofuran, benzothiophene, benzotriazole, imidazopyridine, triazolopyridine, imidazothiazole, pyrazinopyridazine, benzimidazoline, etc. are exemplified.

The term “heteroaryl” includes a monovalent group derived from “aromatic heterocyclic ring” as defined above. “Heteroaryl” includes a five- to seven-membered aromatic group having at least one nitrogen atom, oxygen atom, and/or sulphur atom in the ring; a fused aromatic group comprising two or more said rings; and a fused ring comprising a five- to seven-membered aromatic group having at least one nitrogen atom, oxygen atom, and/or sulphur atom in the ring fused to one or more “aromatic carbocyclic ring” as defined above.

For example, monocyclic aromatic heterocyclic groups such as pyrrolyl, pyrazinyl, pyrazolyl, indolyl, tetrazolyl, furyl, thienyl, pyridyl, imidazolyl, triazolyl, tetrazolyl, triazinyl, pyridazinyl, pyrimidinyl, pyrazinyl, isoxazolyl, thiazolyl, isothiazolyl, thiadiazolyl, oxazolyl, oxadiazolyl, etc; and

fused heterocyclic aromatic groups such as isoindolyl, indazolyl, indolizinyl, isoindolinyl, quinolyl, isoquinolyl, cinnolinyl, phthalazinyl, quinazolinyl, naphthyridinyl, quinoxalinyl, purinyl, pteridinyl, benzimidazolyl, benzisoxazolyl, benzoxazolyl, benzoxadiazolyl, benzisothiazolyl, benzothiazolyl, benzothiadiazolyl, benzofuryl, isobenzofuryl, benzothienyl, benzotriazolyl, imidazopyridyl, triazolopyridyl, imidazothiazolyl, pyrazinopyridazinyl, benzimidazolynyl, etc. are exemplified.

The heteroaryl moiety of “heteroaryloxycarbonyl” is as defined above for “heteroaryl”.

The term “non-aromatic heterocyclic ring” includes non-aromatic rings of “heterocyclic ring” as defined above. “Non-aromatic heterocyclic ring” includes, a five- to seven-membered non-aromatic ring having at least one nitrogen atom, oxygen atom, and/or sulphur atom in the ring; a fused non-aromatic ring consisting of two or more said rings; a fused ring consisting of a five- to seven-membered aromatic ring having at least one nitrogen atom, oxygen atom, and/or sulphur atom in the ring fused to one or more “cycloalkane” as defined above or “cycloalkene” as defined above; or a fused ring consisting of a five- to seven-membered non-aromatic heterocyclic ring having at least one nitrogen atom, oxygen atom, and/or sulphur atom in the ring fused to one or more “aromatic carbocyclic ring” as defined above or “non-aromatic carbocyclic ring” as defined above

For example, non-aromatic heterocyclic ring such as pyrroline, pyrrolidine, imidazoline, imidazolidine, pyrazoline, pyrazolidine, piperidine, piperazine, morpholine, thiomorpholine, thiomorpholine, tetrahydropyrane, dihydropyridine, dihydropyridazine, dihydropyrazine, dioxane, oxathiolane, thiane, tetrahydrofuran, tetrahydropyran, tetrahydrothiazolin, tetrahydroisothiazole, etc.;

a fused non-aromatic heterocyclic ring such as indoline, isoindoline, benzopyrane, benzodioxane, tetrahydroquinoline, benzo[d]oxazole-2(3H)-one, tetrahydrobenzothiophene, etc. are exemplified.

The term “non-aromatic heterocyclic group” includes a monovalent group derived from “non-aromatic heterocyclic ring” as defined above. For example, non-aromatic mono heterocyclic groups such as pyrrolinyl, pyrrolidino, pyrrolidinyl, imidazolynyl, imidazolidinyl, pyrazolinyl, pyrazolidinyl, piperidino, piperidyl, piperidino, piperazinyl, morpholinyl, morpholino, thiomorpholinyl, thiomorpholino, tetrahydropyranyl, dihydropyridyl, dihydropyridazinyl, dihydropyrazinyl, dioxanyl, oxathiolanyl, thianyl, tetrahydrofuryl, tetrahydropyranyl, tetrahydrothiazolinyl, tetrahydroisothiazolinyl, etc.; and fused heterocyclic groups such as benzodioxanyl, tetrahydroquinoline, tetrahydrobenzothienyl, etc. are exemplified.

The term “nitrogen-containing non-aromatic heterocyclic group” includes a monovalent group derived from a four- to seven-membered aromatic group or a fused aromatic ring consisting of two or more said rings which includes at least one nitrogen atom in the ring and optionally includes one or more atoms selected from an oxygen atom and/or a sulphur atom at any position in the ring.

For example, pyrrolinyl, pyrrolidino, pyrrolidinyl, piperidino, piperidyl, piperadino, piperazinyl, morpholinyl, morpholino, thiomorpholino etc. are exemplified.

The non-aromatic heterocyclic ring moiety of “non-aromatic heterocyclic ring-oxy-carbonyl” is as defined above for “non-aromatic heterocyclic ring”.

Substituents for “substituted lower alkyl”, “substituted alkyl”, “substituted lower alkenyl”, “lower alkenyl”, “substituted lower alkynyl”, “substituted alkynyl”, “substituted lower alkyloxy”, “substituted alkyloxy”, “substituted lower alkenyloxy”, “substituted alkenyloxy”, “substituted lower alkynyloxy”, “substituted alkynyloxy”, “substituted lower alkylthio”, “substituted alkylthio”, “substituted lower alkenylthio”, “substituted alkenylthio”, “substituted lower alkynylthio”, “substituted alkynylthio”, “substituted lower alkyloxycarbonyl”, “substituted alkyloxycarbonyl”, “substituted lower alkenyloxycarbonyl”, “substituted alkenyloxycarbonyl”, “substituted lower alkynyloxycarbonyl”, “substituted alkynyloxycarbonyl”, “substituted lower alkylcarbamoyl” and “substituted alkylcarbamoyl” include, but are not limited to, one or more same or different substituents selected from the group comprising: hydroxy, carboxy, halogen (F, Cl, Br, I), lower haloalkyloxy (e.g., CF₃O), cycloalkyl (e.g., cyclopropyl), cycloalkenyl (e.g., cyclopropenyl), lower alkyloxy (e.g., methoxy, ethoxy, propoxy, butoxy, etc.), lower alkenyloxy (e.g., vinyloxy, allyloxy, etc.), lower alkyloxycarbonyl (e.g., methoxycarbonyl, ethoxycarbonyl, tert-butoxycarbonyl, etc.), nitro, nitroso, amino, lower alkylamino (e.g., methylamino, ethylamino, dimethylamino, etc.), acylamino (e.g., acetylamino, benzoylamino, etc.), arylalkylamino (e.g., benzylamino, tritylamino), hydroxyamino, imino, hydroxyimino, lower alkylimino (e.g., methylimino, ethylimino, dimethylimino, etc.), lower alkyloxyimino (e.g., methoxyimino, ethoxyimino, etc.), acylimino (e.g., acetylimino, benzoylimino, etc.), azido, aryl (e.g., phenyl, etc.), arylalkyl (e.g., benzyl, phenylethyl, etc.), arylalkyloxy (e.g., benzyloxy), a non-aromatic heterocyclic group (e.g., pyrrolinyl, piperidyl, piperadino, pyrrolidino, pyrrolidinyl, morpholinyl, morpholino, etc.), heteroaryl (e.g., furyl, thienyl, pyridyl, isoxazolyl, thiazolyl, thiadiazolyl, oxazolyl, oxadiazolyl, tetrazolyl, indolyl, benzofuryl, etc.), heteroarylalkyl (e.g., pyridylmethyl, pyridylethyl, etc.), cyano, isocyano, isocyanato, thiocyanato, isothiocyanato, mercapto, lower alkylthio (e.g., methylthio, etc.), lower alkylsulfonyl (e.g., methanesulfonyl, ethanesulfonyl), carbamoyl, lower alkylcarbamoyl (e.g., methylcarbamoyl, ethylcarbamoyl, dimethylcarbamoyl, etc.), sulfamoyl, lower alkylsulfamoyl, acyl (e.g., formyl, acetyl, etc.), formyloxy, thioformyl, thiocarboxy, dithiocarboxy, thiocarbamoyl, sulfino, sulfo, hydrazino, azido, ureido, amidino, guanidino, phthalimido, tri-lower alkylsilyl (e.g., trimethylsilyl, etc.), or oxo.

Substituents for “substituted alkyl” and “substituted lower alkyl” of R^(1c) are exemplified as follows: cyano; halogen; hydroxy; carboxy; unsubstituted lower alkyloxy; lower alkyloxy substituted with one or more substituents selected from Substituent Group B(Substituent Group B:cycloalkyl, cycloalkenyl, a non-aromatic heterocyclic group, aryl, and heteroaryl); unsubstituted lower alkyloxycarbonyl; lower alkyloxycarbonyl substituted with one or more substituents selected from Substituent Group B; unsubstituted carbamoyl; carbamoyl substituted with one or more substituents selected from Substituent Group C(Substituent Group C:unsubstituted lower alkyl, hydroxyalkyl, dihydroxyalkyl, carboxyalkyl, lower alkyloxyalkyl, unsubstituted cycloalkylalkyl, lower alkyloxycarbonylalkyl, carboxycycloalkylalkyl and lower alkyloxycarbonylalkyl); unsubstituted amino; amino substituted with one or more substituents selected from Substituent Group D(Substituent Group D:lower alkyl, acyl, unsubstituted carbamoyl, lower alkylcarbamoyl, lower hydroxyalkylcarbamoyl, and lower carboxyalkylcarbamoyl); unsubstituted cycloalkyl; cycloalkyl substituted with one or more substituents selected from Substituent Group E(Substituent Group E:lower hydroxyalkyl, carboxy, and lower alkyloxycarbonyl); a non-aromatic heterocyclic group; unsubstituted aryl; and aryl substituted with one or more substituents selected from Substituent Group F(Substituent Group F:halogen, lower alkyl, and lower alkyloxy).

Substituents for “substituted alkyl” and “substituted lower alkyl” of R^(1c) are are exemplified as follows: cyano; halogen; hydroxy; carboxy; methoxy; methoxy substituted with tetrahydrofuryl or morpholino; lower alkyloxycarbonyl; unsubstituted carbamoyl; carbamoyl substituted with one or more substituents selected from Substituent Group G(Substituent Group G:methyl, ethyl, hydroxymethyl, hydroxyethyl, carboxymethyl, carboxyethyl, methoxyoxymethyl, dihydroxyisopropyl, carboxyisopropyl, and carboxycyclopropyl); methoxycarbonyl; ethoxycarbonyl; phenylmethylcarbonyl; cycloalkyl substituted with one or more substituents selected from Substituent Group H(Substituent Group H:hydroxymethyl, carboxy, methoxycarbonyl and ethoxycarbonyl); lower alkylcarbamoyl substituted with one or more substituents selected from Substituent Group I(Substituent Group I:amino, alkyl, acylcarbamoyl, lower alkylcarbamoyl, and hydroxy); unsubstituted phenyl; and phenyl substituted with one or more substituents selected from Substituent Group J(Substituent Group J:halogen, lower alkyl, and lower alkyloxy).

Substituents for “substituted alkyl” and “substituted lower alkyl” of R^(1a) are exemplified as follows: cyano; halogen; hydroxy; carboxy; unsubstituted lower alkyloxy; lower alkyloxy substituted with one or more substituents selected from Substituent Group B(Substituent Group B:cycloalkyl, cycloalkenyl, a non-aromatic heterocyclic group, aryl, and heteroaryl); unsubstituted lower alkyloxycarbonyl; lower alkyloxycarbonyl substituted with one or more substituents selected from Substituent Group B; unsubstituted carbamoyl; carbamoyl substituted with one or more substituents selected from Substituent Group C(Substituent Group C:unsubstituted lower alkyl, hydroxyalkyl, dihydroxyalkyl, carboxyalkyl, lower alkyloxyalkyl, unsubstituted cycloalkylalkyl, lower alkyloxycarbonylalkyl, carboxycycloalkylalkyl and lower alkyloxycarbonylalkyl); unsubstituted amino; amino substituted with one or more substituents selected from Substituent Group D(Substituent Group D:lower alkyl, acyl, unsubstituted carbamoyl, lower alkylcarbamoyl, lower hydroxyalkylcarbamoyl, and lower carboxyalkylcarbamoyl); unsubstituted cycloalkyl; cycloalkyl substituted with one or more substituents selected from Substituent Group E(Substituent Group E:lower hydroxyalkyl, carboxy, and lower alkyloxycarbonyl); a non-aromatic heterocyclic group; unsubstituted aryl; and aryl substituted with one or more substituents selected from Substituent Group F(Substituent Group F:halogen, lower alkyl, and lower alkyloxy).

Substituents for “substituted alkyl” and “substituted lower alkyl” of R^(1a) are exemplified as follows: cyano; halogen; hydroxy; carboxy; methoxy; methoxy substituted with tetrahydrofuryl or morpholino; lower alkyloxycarbonyl; unsubstituted carbamoyl; carbamoyl substituted with one or more substituents selected from Substituent Group G(Substituent Group G:methyl, ethyl, hydroxymethyl, hydroxyethyl, carboxymethyl, carboxyethyl, methoxyoxymethyl, dihydroxyisopropyl, carboxyisopropyl, and carboxycyclopropyl); methoxycarbonyl; ethoxycarbonyl; phenylmethylcarbonyl; cycloalkyl substituted with one or more substituents selected from Substituent Group H(Substituent Group H:hydroxymethyl, carboxy, methoxycarbonyl and ethoxycarbonyl); lower alkylcarbamoyl substituted with one or more substituents selected from Substituent Group I(Substituent Group I:amino, alkyl, acylcarbamoyl, lower alkylcarbamoyl, and hydroxy); unsubstituted phenyl; and phenyl substituted with one or more substituents selected from Substituent Group J(Substituent Group J:halogen, lower alkyl, and lower alkyloxy).

A substituent for “substituted acyl” is selected from the group comprising: substituents for “substituted lower alkyl” as defined above, substituents for “lower alkyl” as defined above, substituents for “lower alkenyl” as defined above, and substituents for “lower alkynyl” as defined above. Especially, when R of acyl (R—C(═O)—) is “cycloalkyl”, “cycloalkenyl”, “a non-aromatic heterocyclic group”, “aryl” or “heteroaryl”, a substituent for each ring is lower alkyl (e.g., methyl, ethyl, isopropyl, tert-butyl, etc.), lower haloalkyl(e.g., CF₃, CH₂CF₃, CH₂CCl₃, etc.), lower alkenyl, lower alkynyl(e.g., ethynyl), lower alkyloxy(e.g., methoxy, ethoxy, isopropyloxy), or halogen(e.g., F, Cl, etc.), etc.

For example, a substituent for “substituted carbamoyl” or “substituted sulfamoyl” is, but is not limited to, one or more same or different substituents selected from the group comprising: hydroxy, carboxy, halogen(F, Cl, Br, I), lower alkyl(e.g., methyl, ethyl), lower alkenyl(e.g., vinyl), lower alkynyl(e.g., ethynyl), cycloalkyl(e.g., cyclopropyl), cycloalkenyl(e.g., cyclopropenyl), lower alkyloxycarbonyl(e.g., methoxycarbonyl, ethoxycarbonyl, tert-butoxycarbonyl, etc.), amino, lower alkylamino e.g., methylamino, ethylamino, dimethylamino, etc.), acylamino(e.g., acetylamino, benzoylamino, etc.), arylalkylamino(e.g., benzylamino, tritylamino), hydroxyamino, aryl(e.g., phenyl, etc.), cyano, isocyano, isocyanato, thiocyanato, isothiocyanato or acyl(e.g., formyl, acetyl, etc.).

For example, a substituent for “substituted amino” is, but is not limited to, one or more same or different substituents selected from the group comprising: lower alkyl(e.g., methyl, ethyl, isopropyl, tert-butyl, etc.), lower haloalkyl(e.g., CF₃, CH₂CF₃, CH₂CCl₃, etc.), lower hydroxyalkyl(e.g., hydroxyethyl, —C(CH₃)₂CH₂OH, etc.), lower alkenyl(e.g., vinyl), lower alkynyl(e.g., ethynyl), cycloalkyl(e.g., cyclopropyl), cycloalkenyl(e.g., cyclopropenyl), lower alkyloxy(e.g., methoxy, ethoxy, propoxy, butoxy, etc.), lower haloalkyloxy(e.g., CF₃O), lower alkenyloxy(e.g., vinyloxy, allyloxy, etc.), lower alkyloxycarbonyl(tert-butyloxycarbonyl, etc.), amino, lower alkylamino(e.g., methylamino, ethylamino, dimethylamino, etc.), acylamino(e.g., acetylamino, benzoylamino, etc.), arylalkylamino(e.g., benzylamino, tritylamino), hydroxyamino, imino, hydroxyimino, lower alkylimino(e.g., methylimino, ethylimino, dimethylimino, etc.), lower alkyloxyimino(e.g., methoxyimino, ethoxyimino, etc.), acyl imino(e.g., acetylimino, benzoylimino, etc.), aryl(e.g., phenyl, etc.), arylalkyl(e.g., benzyl, etc.), aryloxy(e.g., phenoxy, etc.), a non-aromatic heterocyclic group(e.g., pyrrolinyl, pyrrolidino, piperidino, piperidyl, piperadino, piperazinyl, morpholinyl, morpholino, etc.), heteroaryl(e.g., pyridyl, thienyl, thiazolyl, furyl, etc.), heteroarylalkyl(e.g., pyridylmethyl, thienylmethyl, thiazolylmethyl, furylmethyl, etc.), non-aromatic heterocyclic ring-oxy(piperadinooxy, piperidinooxy, etc.), heteroaryloxy(pyridyl oxy, etc.), hydroxy, halogen(F, Cl, Br, I), cyano or acyl(e.g., formyl, acetyl, etc.).

For example, a substituent for “substituted cycloalkyl”, “substituted cycloalkenyl”, “substituted aryl”, “a substituted heterocyclic group”, “substituted heteroaryl”, “substituted arylalkyl”, “substituted heteroarylalkyl”, “a substituted non-aromatic heterocyclic group” or “a substituted nitrogen-containing non-aromatic heterocyclic group” is, but is not limited to, one or more same or different substituents selected from the group comprising: lower alkyl(e.g., methyl, ethyl, isopropyl, tert-butyl, etc.), lower haloalkyl(e.g., CF₃, CH₂CF₃, CH₂CCl₃, etc.), lower haloalkyloxy(e.g., CF₃O, CHCF₂O, etc.), lower alkenyl(e.g., vinyl), lower alkynyl (e.g., ethynyl), cycloalkyl(e.g., cyclopropyl), cycloalkenyl(e.g., cyclopropenyl), lower alkyloxy(e.g., methoxy, ethoxy, propoxy, butoxy, etc.), lower alkenyloxy(e.g., vinyloxy, allyloxy, etc.), lower alkyloxycarbonyl(e.g., methoxycarbonyl, ethoxycarbonyl, tert-butoxycarbonyl, etc.), nitro, nitroso, amino, lower alkylamino(e.g., methylamino, ethylamino, dimethylamino, etc.), acylamino(e.g., acetylamino, benzoylamino, etc.), arylalkylamino(e.g., benzylamino, tritylamino), hydroxyamino, imino, hydroxyimino, lower alkylimino(e.g., methylimino, ethylimino, dimethylimino, etc.), lower alkyloxyimino(e.g., methoxyimino, ethoxyimino, etc.), acyl imino(e.g., acetylimino, benzoylimino, etc.), azido, aryl(e.g., phenyl, etc.), arylalkyl(e.g., benzyl, etc.), aryloxy(e.g., phenoxy, etc.), arylalkyloxy(e.g., benzyloxy, etc.), a non-aromatic heterocyclic group(e.g., pyrrolinyl, pyrrolidino, piperidino, piperidyl, piperadino, piperazinyl, morpholinyl, morpholino, etc.), heteroaryl(e.g., pyridyl, thienyl, thiazolyl, furyl, etc.), heteroarylalkyl(e.g., pyridylmethyl, thienylmethyl, thiazolylmethyl, furylmethyl, etc.), non-aromatic heterocyclic ring-oxy(piperadinooxy, piperidinooxy, etc.), heteroaryloxy(pyridyl oxy, etc.), cyano, isocyano, isocyanato, thiocyanato, isothiocyanato, mercapto, lower alkylthio(e.g., methylthio, etc.), lower alkylsulfonyl(e.g., methanesulfonyl, ethanesulfonyl), substituted or unsubstituted carbamoyl(e.g., carbamoyl, N-methyl-N-methoxycarbamoyl, etc.), substituted or unsubstituted lower alkylcarbamoyl(e.g., methylcarbamoyl, ethylcarbamoyl, dimethylcarbamoyl, hydroxyethylcarbamoyl, trifluoromethylcarbamoyl, trifluoroethylcarbamoyl, etc.), sulfamoyl, lower alkylsulfamoyl, hydroxy, carboxy, halogen(F, Cl, Br, I), acyl(e.g., formyl, acetyl, etc.), formyl oxy, thio formyl, thiocarboxy, dithiocarboxy, thiocarbamoyl, sulfino, sulfo, hydrazino, azido, ureido, amidino, guanidino, or phthalimido and oxo.

Substituents for “substituted cycloalkyl”, “substituted cycloalkenyl”, “a substituted non-aromatic heterocyclic group”, “substituted aryl” and “substituted heteroaryl” of R^(1c) are exemplified as follows: halogen, lower alkyl, lower haloalkyl, lower alkyloxy, cyano, nitro, lower alkylamino, etc.

Substituents for “substituted cycloalkyl”, “substituted cycloalkenyl”, “a substituted non-aromatic heterocyclic group”, “substituted aryl” and “substituted heteroaryl” of R^(1c) are exemplified as follows: methyl, ethyl, isopropyl, tert-butyl, trifluoromethyl, methoxy, methylamino, dimethylamino, amino, Cl, F, cyano, etc.

Substituents for “substituted cycloalkyl”, “substituted cycloalkenyl”, “a substituted non-aromatic heterocyclic group”, “substituted aryl” and “substituted heteroaryl” of R^(1a) are exemplified as follows: halogen, lower alkyl, lower haloalkyl, lower alkyloxy, cyano, nitro, lower alkylamino, etc.

Substituents for “substituted cycloalkyl”, “substituted cycloalkenyl”, “a substituted non-aromatic heterocyclic group”, “substituted aryl” and “substituted heteroaryl” of R^(1a) are exemplified as follows: methyl, ethyl, isopropyl, tert-butyl, trifluoromethyl, methoxy, methylamino, dimethylamino, amino, Cl, F, cyano, etc.

Substituents for “a substituted nitrogen-containing non-aromatic heterocyclic group” wherein the ring is formed by R⁷ and R^(1a) include oxo.

Substituents for “substituted cycloalkyl”, “substituted cycloalkenyl”, “a substituted non-aromatic heterocyclic group”, “substituted aryl” and “substituted heteroaryl” of R² are exemplified as follows: lower alkyl substituted with halogen, unsubstituted lower alkyl, unsubstituted lower alkenyl, unsubstituted lower alkynyl, unsubstituted lower alkyloxy, unsubstituted lower alkylthio, unsubstituted lower alkylamino, halogen, etc.

Substituents for “substituted cycloalkyl”, “substituted cycloalkenyl”, “a substituted non-aromatic heterocyclic group”, “substituted aryl” and “substituted heteroaryl” of R² are exemplified as follows: lower alkyl, lower trifluoroalkyl, lower alkyloxy, lower alkylamino, nitro, cyano, halogen, etc.

Substituents for “substituted cycloalkyl”, “substituted cycloalkenyl”, “a substituted non-aromatic heterocyclic group”, “substituted aryl” and “substituted heteroaryl” of R² are exemplified as follows: methyl, tert-butyl, trifluoromethyl, methoxy, dimethylamino, nitro, cyano, Cl and F, etc.

Substituents for “substituted cycloalkyl”, “substituted cycloalkenyl”, “a substituted non-aromatic heterocyclic group”, “substituted aryl” and “substituted heteroaryl” of R³ are exemplified as follows: halogen, hydroxy, nitro, cyano, carboxy, lower alkyl, lower alkyl substituted with halogen, lower alkyl substituted with amino substituted with lower alkyl, unsubstituted lower alkyloxy, lower alkyloxy substituted with one or more substituents selected from Substituent Group A(Substituent Group A:cyano, lower alkyloxy, and lower alkyloxycarbonyl), cycloalkyloxy, non-aromatic heterocyclic ring-oxy, aryloxy, heteroaryloxy, trifluoromethyl lower alkyloxy, lower difluoroalkyloxy, lower alkylthio, carboxy, lower alkyloxycarbonyl, lower alkylcarbonyl, non-aromatic heterocyclic ring-carbonyl, lower hydroxyalkylcarbamoyl, cycloalkylcarbamoyl, cycloalkenylcarbamoyl, arylcarbamoyl, non-aromatic heterocyclic ring carbamoyl, heteroarylcarbamoyl, lower alkylamino, lower alkylsulfonylamino, lower alkylsulfonyl, trifluoroalkylsulfonyl, sulfamoyl, lower alkylsulfamoyl, lower alkylsulfino, aryl, heteroaryl, cycloalkyl, cycloalkenyl, a non-aromatic heterocyclic group, etc.

Substituents for “substituted cycloalkyl”, “substituted cycloalkenyl”, “a substituted non-aromatic heterocyclic group”, “substituted aryl” and “substituted heteroaryl” of R³ are exemplified as follows: halogen, nitro, cyano, hydroxy, carboxy, methyl, isopropyl, n-butyl, isobutyl, t-butyl, trifluoromethyl, methoxy, ethoxy, isopropyloxy, cyano methoxy, methoxyethoxy, ethoxycarbonylmethoxy, cyclopenteneoxy, phenoxy, trifluoromethoxy, difluoromethoxy, piperazinyloxy, methylthio, propylthio, t-butylcarbonyl, morpholino carbonyl, piperadinocarbonyl, morpholino ethylcarbonyl, methoxycarbonyl, methylcarbamoyl, dimethylcarbamoyl, hydroxyethylcarbamoyl, isopropylcarbamoyl, cyclopropylcarbamoyl, phenylcarbamoyl, sulfamoyl, trifluoromethylsulfonyl, propylsulfino, methylamino, dimethylamino, ethylamino, diethylamino, methylsulfonylamino, isoxazolyl, furyl, morpholino, tetrahydro-2H-pyranyl, piperadino, etc.

Embodiments of the compound of the present invention are described below.

Embodiments of the compound represented by (II-A) to (II-L) in the below in the formula (II):

are as follows.

(II-A): The compound represented by the formula (II),

wherein R^(1c), R^(4a), R^(4b), R⁵ and ═Z are as defined in the above (1);

-   R² is substituted or unsubstituted aryl, or substituted or     unsubstituted heteroaryl: -   R³ is substituted or unsubstituted aryl, or substituted or     unsubstituted heteroaryl: — -   X— is —N(R⁵)—; and -   n is 1, or its pharmaceutically acceptable salt, or a solvate     thereof.

(II-B): The compound represented by the formula (II),

wherein R^(1c), R^(4a), R^(4b), and R⁵ are as defined in the above (1);

-   R² is substituted or unsubstituted aryl, or substituted or     unsubstituted heteroaryl: -   R³ is substituted or unsubstituted aryl, or substituted or     unsubstituted heteroaryl: -   —X— is —N(R⁵)—; -   ═Z is ═O; and -   n is 1, or its pharmaceutically acceptable salt, or a solvate     thereof.

(II-C): The compound represented by the formula (II),

wherein R^(4a), R^(4b), and R⁵ are as defined in the above (1);

-   R^(1c) and R² are each independently substituted or unsubstituted     aryl, or substituted or unsubstituted heteroaryl; -   R³ is a group represented by the formula:

wherein ring A is aryl or heteroaryl:

-   s is an integer of 0 to 3; -   R⁹ is each independently halogen, hydroxy, substituted or     unsubstituted alkyl, substituted or unsubstituted alkyloxy,     substituted or unsubstituted lower alkenyl, substituted or     unsubstituted lower alkenyloxy, substituted or unsubstituted lower     alkynyl, substituted or unsubstituted lower alkynyloxy, substituted     or unsubstituted lower alkylthio, substituted or unsubstituted acyl,     carboxy, substituted or unsubstituted lower alkyloxycarbonyl,     substituted or unsubstituted carbamoyl, substituted or unsubstituted     lower alkylcarbamoyl, substituted or unsubstituted amino,     substituted or unsubstituted sulfamoyl, cyano, nitro, nitrile,     substituted or unsubstituted cycloalkyl, substituted or     unsubstituted cycloalkyloxy, substituted or unsubstituted     cycloalkenyl, substituted or unsubstituted cycloalkenyloxy, a     substituted or unsubstituted non-aromatic heterocyclic group,     substituted or unsubstituted non-aromatic heterocyclic ring-oxy,     substituted or unsubstituted aryl, substituted or unsubstituted     aryloxy, substituted or unsubstituted heteroaryl or substituted or     unsubstituted heteroaryloxy; -   —X— is —N(R⁵)—; -   ═Z is ═O; and -   n is 1, or its pharmaceutically acceptable salt, or a solvate     thereof.

(II-D): The compound represented by the formula (II),

wherein R^(1c) is substituted lower alkyl;

-   R² is substituted or unsubstituted aryl, or substituted or     unsubstituted heteroaryl; -   R³ is a group represented by the formula:

wherein R^(9a) and R^(9b) are as defined in the above (8);

-   both of R^(4a) and R^(4b) are hydrogen; -   —X— is —NH—; and -   ═Z is ═O; -   n is 1, or its pharmaceutically acceptable salt, or a solvate     thereof.

(II-E): The compound represented by the formula (II),

wherein R^(1c) is lower alkyl substituted with one or more substituents selected from Substituent Group L(cyano, halogen, hydroxy, carboxy, unsubstituted lower alkyloxy, lower alkyloxy substituted with cycloalkyl, lower alkyloxy substituted with cycloalkenyl, lower alkyloxy substituted with a non-aromatic heterocyclic group, lower alkyloxy substituted with non-aryl, unsubstituted lower alkyloxy, lower alkyloxy substituted with heteroaryl, lower alkyloxycarbonyl, lower alkyloxycarbonyl substituted with cycloalkyl, lower alkyloxycarbonyl substituted with cycloalkenyl, lower alkyloxycarbonyl substituted with a non-aromatic heterocyclic group, lower alkyloxycarbonyl substituted with non-aryl, lower alkyloxycarbonyl substituted with heteroaryl, lower alkyloxycarbonylcarbonyl, unsubstituted carbamoyl, lower alkylcarbamoyl, lower alkylcarbamoyl substituted with hydroxy, lower alkylcarbamoyl substituted with carboxy, lower alkylcarbamoyl substituted with lower alkyloxy, lower alkylcarbamoyl substituted with unsubstituted cycloalkyl, and lower alkylcarbamoyl substituted with carboxycycloalkyl, unsubstituted amino, lower alkyl, acyl, unsubstituted carbamoyl, lower alkylcarbamoyl, lower alkylcarbamoyl substituted with hydroxy, and lower alkylcarbamoyl substituted with carboxy, amino substituted with lower alkyl, amino substituted with acyl, amino substituted with unsubstituted carbamoyl, amino substituted with lower alkylcarbamoyl, amino substituted with lower hydroxyalkylcarbamoyl, amino substituted with lower carboxyalkylcarbamoyl, a non-aromatic heterocyclic ring substituted with lower hydroxyalkyl, a non-aromatic heterocyclic ring substituted with carboxy, a non-aromatic heterocyclic ring substituted with lower alkyloxycarbonyl, a non-aromatic heterocyclic ring substituted with lower hydroxyalkyl, a non-aromatic heterocyclic ring substituted with carboxy, a non-aromatic heterocyclic ring substituted with lower alkyloxycarbonyl, halogen and lower alkyloxy);

-   R² is aryl substituted with one or more substituents selected from     Substituent Group S(Substituent Group S:lower alkyl, lower alkyloxy,     trifluoromethyl, dimethylamino, nitro, cyano, and halogen), or     heteroaryl substituted with one or more substituents selected from     Substituent Group S; -   R³ is a group represented by the formula:

wherein R^(9a) and R^(9b) are each independently halogen, hydroxy, cyano, nitro, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkenyl, substituted or unsubstituted lower alkynyl, substituted or unsubstituted lower alkyloxy, substituted or unsubstituted lower alkenyloxy, substituted or unsubstituted lower alkynyloxy, substituted or unsubstituted lower alkylthio, substituted or unsubstituted acyl, carboxy, substituted or unsubstituted lower alkyloxycarbonyl, substituted or unsubstituted carbamoyl, substituted or unsubstituted amino, substituted or unsubstituted sulfamoyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted a non-aromatic heterocyclic group, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted cycloalkyloxy, substituted or unsubstituted cycloalkenyloxy, substituted or unsubstituted non-aromatic heterocyclic ring-oxy, substituted or unsubstituted aryloxy, or substituted or unsubstituted heteroaryloxy;

-   both of R^(4a) and R^(4b) are hydrogen; -   —X— is —NH—; -   ═Z is ═O; and -   n is 1, or its pharmaceutically acceptable salt, or a solvate     thereof.

(II-F): The compound represented by the formula (II),

wherein ═Z is ═O;

-   R^(1c) is substituted alkyl: -   R² is substituted or unsubstituted cycloalkyl, substituted or     unsubstituted cycloalkenyl, a substituted or unsubstituted     non-aromatic heterocyclic group, substituted or unsubstituted aryl     or substituted or unsubstituted heteroaryl; -   n is 1; -   R³ is substituted or unsubstituted aryl, or substituted or     unsubstituted heteroaryl; -   R^(4a) and R^(4b) are hydrogen; and -   —X— is —NH—, or its pharmaceutically acceptable salt, or a solvate     thereof.

(II-G): The compound represented by the formula (II),

wherein ═Z is ═O;

-   R^(1c) is substituted alkyl; -   R² is substituted or unsubstituted aryl, or substituted or     unsubstituted heteroaryl; -   n is 1; -   R³ is substituted or unsubstituted aryl, or substituted or     unsubstituted heteroaryl; -   R^(4a) and R^(4b) are hydrogen; and -   —X— is —NH—, or its pharmaceutically acceptable salt, or a solvate     thereof.

(II-H): The compound represented by the formula (II),

wherein ═Z is ═O;

-   R² is substituted or unsubstituted aryl; -   n is 1; -   R³ is substituted or unsubstituted aryl, or substituted or     unsubstituted heteroaryl; -   R^(4a) and R^(4b) are hydrogen; -   —X— is —NH—; and -   R^(1c) is a group represented by the formula:

wherein R^(1c′) is carboxy or substituted or unsubstituted alkyloxycarbonyl, or its pharmaceutically acceptable salt, or a solvate thereof.

(II-I): The compound represented by the formula (II),

wherein ═Z is ═O;

-   R² is substituted or unsubstituted aryl; -   n is 1; -   R³ is substituted or unsubstituted aryl, or substituted or     unsubstituted heteroaryl; -   R^(4a) and R^(4b) are hydrogen; -   —X— is —NH—; and -   R^(1c) is a group represented by the formula:

wherein R^(1c′) is carboxy, or substituted or unsubstituted alkyloxycarbonyl, or its pharmaceutically acceptable salt, or a solvate thereof.

(II-J): The compound represented by the formula (II),

wherein ═Z is ═O;

-   R² is substituted or unsubstituted aryl; -   n is 1; -   R³ is substituted or unsubstituted aryl, or substituted or     unsubstituted heteroaryl; -   R^(4a) and R^(4b) are hydrogen; -   —X— is —NH—; and -   R^(1c) is a group represented by the formula:

wherein R^(1c′) is carboxy, or substituted or unsubstituted alkyloxycarbonyl, or its pharmaceutically acceptable salt, or a solvate thereof.

(II-K): The compound represented by the formula (II),

wherein ═Z is ═O;

-   R² is substituted or unsubstituted aryl; -   n is 1; -   R³ is substituted or unsubstituted aryl, or substituted or     unsubstituted heteroaryl; -   R^(4a) and R^(4b) are hydrogen; -   —X— is —NH—; and -   R^(1c) is a group represented by the formula:

wherein R^(1c′) is carboxy, or substituted or unsubstituted alkyloxycarbonyl, or its pharmaceutically acceptable salt, or a solvate thereof.

(II-L): The compound represented by the formula (II),

wherein ═Z is ═O;

-   R² is substituted or unsubstituted aryl; -   n is 1; -   R³ is substituted or unsubstituted aryl, or substituted or     unsubstituted heteroaryl; -   R^(4a) and R^(4b) are hydrogen; -   —X— is —NH—; and -   R^(1c) is a group represented by the formula:

wherein R^(1c′) is carboxy, or substituted or unsubstituted alkyloxycarbonyl, or its pharmaceutically acceptable salt, or a solvate thereof.

Embodiments of the compound represented by (III-A) to (III-I) in the below in the formula (III):

are as follows.

(III-A): The compound represented by the formula (III),

wherein R^(1a), R^(4a), R^(4b), R⁵ and —Y— are as defined in the above (1);

-   R² is substituted or unsubstituted aryl, or substituted or     unsubstituted heteroaryl; -   R³ is substituted or unsubstituted aryl, or substituted or     unsubstituted heteroaryl; -   —X— is —N(R⁵)—; and -   n is 1, or its pharmaceutically acceptable salt, or a solvate     thereof.

(III-B): The compound represented by the formula (III),

wherein R^(1a), R^(4a), R^(4b) and R⁵ are as defined in the above (1);

-   R² is substituted or unsubstituted aryl, or substituted or     unsubstituted heteroaryl; -   R³ is substituted or unsubstituted aryl, or substituted or     unsubstituted heteroaryl; -   —X— is —N(R⁵)—; -   —Y— is —O—; and -   n is 1, or its pharmaceutically acceptable salt, or a solvate     thereof.

(III-C): The compound represented by the formula (III),

wherein R^(1a) and R² are each independently substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;

-   R³ is a group represented by the formula:

wherein ring A is aryl or heteroaryl;

-   s is an integer of 0 to 3; -   R⁹ is each independently halogen, hydroxy, substituted or     unsubstituted alkyl, substituted or unsubstituted alkyloxy,     substituted or unsubstituted lower alkenyl, substituted or     unsubstituted lower alkenyloxy, substituted or unsubstituted lower     alkynyl, substituted or unsubstituted lower alkynyloxy, substituted     or unsubstituted lower alkylthio, substituted or unsubstituted acyl,     carboxy, substituted or unsubstituted lower alkyloxycarbonyl,     substituted or unsubstituted carbamoyl, substituted or unsubstituted     lower alkylcarbamoyl, substituted or unsubstituted amino,     substituted or unsubstituted sulfamoyl, cyano, nitro, nitrile,     substituted or unsubstituted cycloalkyl, substituted or     unsubstituted cycloalkyloxy, substituted or unsubstituted     cycloalkenyl, substituted or unsubstituted cycloalkenyloxy,     substituted or unsubstituted a non-aromatic heterocyclic group,     substituted or unsubstituted non-aromatic heterocyclic ring-oxy,     substituted or unsubstituted aryl, substituted or unsubstituted     aryloxy, substituted or unsubstituted heteroaryl or substituted or     unsubstituted heteroaryloxy; -   —X— is —N(R⁵)—; -   —Y— is —O—; and -   n is 1, or its pharmaceutically acceptable salt, or a solvate     thereof.

(III-D): The compound represented by the formula (III),

wherein R^(1a) is substituted lower alkyl;

-   R² is substituted or unsubstituted aryl, or substituted or     unsubstituted heteroaryl; -   R³ is a group represented by the formula:

wherein R^(9a) and R^(9b) are as defined in the above (8);

-   both of R^(4a) and R^(4b) are hydrogen; -   —X— is —NH—; -   —Y— is —O—; and -   n is 1, or its pharmaceutically acceptable salt, or a solvate     thereof.

(III-E): The compound represented by the formula (III),

wherein R^(1a) is lower alkyl substituted with one or more substituents selected from Substituent Group L;

-   R² is aryl substituted with one or more substituents selected from     Substituent Group L, or heteroaryl substituted with one or more     substituents selected from Substituent Group S; -   R³ is a group represented by the formula:

wherein R^(9a) and R^(9b) are each independently halogen, hydroxy, cyano, nitro, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkenyl, substituted or unsubstituted lower alkynyl, substituted or unsubstituted lower alkyloxy, substituted or unsubstituted lower alkenyloxy, substituted or unsubstituted lower alkynyloxy, substituted or unsubstituted lower alkylthio, substituted or unsubstituted acyl, carboxy, substituted or unsubstituted lower alkyloxycarbonyl, substituted or unsubstituted carbamoyl, substituted or unsubstituted amino, substituted or unsubstituted sulfamoyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted a non-aromatic heterocyclic group, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted cycloalkyloxy, substituted or unsubstituted cycloalkenyloxy, substituted or unsubstituted non-aromatic heterocyclic ring-oxy, substituted or unsubstituted aryloxy, or substituted or unsubstituted heteroaryloxy: both of R^(4a) and R^(4b) are hydrogen;

-   —X— is —NH—; -   —Y— is —O—; and -   n is 1, or its pharmaceutically acceptable salt, or a solvate     thereof.

(III-F): The compound represented by the formula (III),

wherein —Y— is —O— or —N(R⁷)—:

-   R⁷ is hydrogen, substituted or unsubstituted alkyl, or substituted     or unsubstituted acyl: -   R^(1a) is hydrogen, substituted or unsubstituted alkyl, substituted     or unsubstituted alkenyl, or substituted or unsubstituted alkynyl: -   R² is substituted or unsubstituted cycloalkyl, substituted or     unsubstituted cycloalkenyl, a substituted or unsubstituted     non-aromatic heterocyclic group, substituted or unsubstituted aryl,     or substituted or unsubstituted heteroaryl: -   n is 1; -   R³ is substituted or unsubstituted aryl, or substituted or     unsubstituted heteroaryl: -   R^(4a) and R^(4b) are hydrogen; and -   —X— is —NH—, or its pharmaceutically acceptable salt, or a solvate     thereof.

(III-G): The compound represented by the formula (III),

wherein —Y— is —O— or —N(R⁷)—:

-   R⁷ is hydrogen, or substituted or unsubstituted alkyl: -   R^(1a) is hydrogen, substituted or unsubstituted alkyl, substituted     or unsubstituted alkenyl, or substituted or unsubstituted alkynyl; -   R² is substituted or unsubstituted aryl; -   n is 1; -   R³ is substituted or unsubstituted aryl, or substituted or     unsubstituted heteroaryl; -   R^(4a) and R^(4b) are hydrogen; and -   —X— is —NH—, or its pharmaceutically acceptable salt, or a solvate     thereof.

(III-H): The compound represented by the formula (III),

wherein —Y— is —N(R⁷)—;

-   R⁷ and R^(1a) are taken together a substituted or unsubstituted     nitrogen-containing non-aromatic heterocyclic group; -   R² is substituted or unsubstituted aryl: -   n is 1; -   R³ is substituted or unsubstituted aryl, or substituted or     unsubstituted heteroaryl: -   R^(4a) and R^(4b) are hydrogen; and -   —X— is —NH—, or its pharmaceutically acceptable salt, or a solvate     thereof.

(III-I): The compound represented by the formula (III),

wherein —Y— is —O— or —N(R⁷)—;

-   R⁷ is hydrogen, or substituted or unsubstituted alkyl; -   R² is substituted or unsubstituted aryl; -   n is 1; -   R³ is substituted or unsubstituted aryl, or substituted or     unsubstituted heteroaryl: -   R^(4a) and R^(4b) are hydrogen; -   —X— is —NH—; and -   R^(1a) is a group represented by the formula:

wherein R^(1a′) is carboxy, or substituted or unsubstituted alkyloxycarbonyl, or its pharmaceutically acceptable salt, or a solvate thereof.

(III-J): The compound represented by the formula (III),

wherein —Y— is —O— or —N(R⁷)—;

-   R⁷ is hydrogen, or substituted or unsubstituted alkyl; -   R² is substituted or unsubstituted aryl; -   n is 1; -   R³ is substituted or unsubstituted aryl or substituted or     unsubstituted heteroaryl; -   R^(4a) and R^(4b) are hydrogen; -   —X— is —NH—; and -   R^(1a) is a group represented by the formula:

wherein R^(1a′) is carboxy, or substituted or unsubstituted alkyloxycarbonyl, or its pharmaceutically acceptable salt, or a solvate thereof.

(III-K): The compound represented by the formula (III),

wherein —Y— is —O— or —N(R⁷)—;

-   R⁷ is hydrogen, or substituted or unsubstituted alkyl; -   R² is substituted or unsubstituted aryl; -   n is 1; -   R³ is substituted or unsubstituted aryl, or substituted or     unsubstituted heteroaryl; -   R^(4a) and R^(4b) are hydrogen; -   —X— is —NH—; and -   R^(1a) is a group represented by the formula:

wherein R^(1a′) is carboxy, or substituted or unsubstituted alkyloxycarbonyl, or its pharmaceutically acceptable salt, or a solvate thereof.

(III-L): The compound represented by the formula (III),

wherein —Y— is —O— or —N(R⁷)—;

-   R⁷ is hydrogen, or substituted or unsubstituted alkyl; -   R² is substituted or unsubstituted aryl; -   n is 1; -   R³ is substituted or unsubstituted aryl; -   R^(4a) and R^(4b) are hydrogen; -   —X— is —NH—; and -   R^(1a) is a group represented by the formula:

wherein R^(1a′) is carboxy, or substituted or unsubstituted alkyloxycarbonyl, or its pharmaceutically acceptable salt, or a solvate thereof.

(III-M): The compound represented by the formula (III),

wherein —Y— is —O— or —N(R⁷)—;

-   R⁷ is hydrogen, or substituted or unsubstituted alkyl; -   R² is substituted or unsubstituted aryl; -   n is 1; -   R³ is substituted or unsubstituted aryl, or substituted or     unsubstituted heteroaryl; -   R^(4a) and R^(4b) are hydrogen; -   —X— is —NH—; and -   R^(1a) is a group represented by the formula:

wherein R^(1a′) is carboxy, or substituted or unsubstituted alkyloxycarbonyl, or its pharmaceutically acceptable salt, or a solvate thereof.

General procedures for the synthesis of the compound of the invention are described bellow. Starting materials and reaction reagents used in such synthesis are commercially available or can be prepared according to methods well known in the art using compounds commercially available.

The compound of the present invention represented by the general formula (I), (II) and (III) is able to be prepared in accordance with the synthetic methods as described bellow.

[Method A]

wherein, R¹⁰ is lower alkyl; Hal¹ is halogen; all other variables are as defined above.

[Process 1]

Compound (i) or a salt thereof such as hydrochloride salt or hydrobromide salt is reacted with isocyanate (ii) in a solvent such as N,N-dimethylformamide, N,N-dimethylacetamide, N,N-dimethylimidazolidinone or dimethylsulfoxide, in the presence of a base such as DBU, triethylamine or pyridine, at temperature of −20° C. to 50° C., preferably ice-cooling. Then, the obtained reaction mixture is reacted with a condensing agent such as 1,1′-carbonyldiimidazole, and a base such as DBU, triethylamine or pyridine, at temperature of −20° C. to 50° C., preferably ice-cooling to give compound (iii).

[Process 2]

Compound (v) may be prepared by the reaction of compound (iii) and compound (iv) in a solvent such as acetonitrile, acetone, DMF or DMSO, in the presence of a base such as potassium carbonate or sodium carbonate, at temperature of 50° C. to reflux temperature, preferably reflux temperature.

[Process 3]

The compound represented by the general formula (II) may be prepared by the reaction of compound (v) and compound (vi) in a solvent such as NMP, DMF or DMSO, or without solvent, at temperature of 150° C. to 250° C., preferably 200° C. to 230° C., under microwave radiation. Also this compound may be prepared by the reaction of compound (v) and compound (vi) in a solvent such as t-butanol, in the presence of an acid such as acetic acid, at temperature of 60° C. to 150° C., preferably 80° C. to 120° C.

The chiral compound (II) may be prepared by using chiral isocyanate (ii).

[Method B]

wherein, Hal² and Hal³ are halogen; all other variables are as defined above.

[Process 1]

Compound (ix) may be prepared by the reaction of compound (vii) and alkylating reagent (viii) in a solvent such as methanol or ethanol at temperature of −40° C. to 30° C., preferably ice-cooling.

[Process 2]

Compound (x) may be prepared by the reaction of compound (ix) and isocyanate such as N-chlorocarbonylisocyanate in a solvent such as dichloromethane, chloroform or 1,2-dichloroethane, in the presence of a base such as triethylamine or N,N-diisopropylamine, at temperature of −20° C. to 30° C., preferably ice-cooling.

[Process 3]

Compound (xi) may be prepared by the reaction of compound (x) and compound (vi) in a solvent such as t-butanol, iso-propanol, ethanol or acetonitrile, in the presence of an acid such as acetic acid, formic acid or methanesulfonic acid, at reflux temperature.

[Process 4]

The compound represented by the general formula (II) may be prepared by the reaction of compound (xi) and compound (xii) in a solvent such as DMF or NMP, in the presence of a base such as potassium t-butoxide or sodium hydride, at temperature of 40° C. to 100° C., preferably 50° C. to 70° C.

The chiral compound (II) may be prepared by using chiral compound (xii).

[Method C]

wherein, Pg¹ is an appropriate hydroxy protecting group; s is an integer of 1 to 4; all other variables are as defined above.

[Process 1]

The mixture of compound (x) obtained by Method B and alcohol (xii) such as 2-(tetrahydro-2H-pyran-2-yloxy)ethanol, where the other hydroxy group is protected, in a solvent such as THF or dioxane, is reacted with triphenylphosphine or the like and diethyl azodicarboxylate or the like to give compound (xiii).

[Process 2]

Compound (xiv) may be prepared by the reaction of compound (xiii) and compound (vi) in the presence of an acid such as formic acid or acetic acid, at reflux temperature.

[Method D]

wherein, Pg² is an appropriate amino protecting group; R¹¹ is substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl alkyl, substituted or unsubstituted heteroaryl alkyl, substituted or unsubstituted lower alkenyl, substituted or unsubstituted lower alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted acyl, substituted or unsubstituted a non-aromatic heterocyclic group, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl; R¹² is hydroxy or halogen; t is an integer of 1 to 4; all other variables are as defined above.

[Process 1]

Compound (xv) obtained by Method A or B is reacted with an acid such as a solution of hydrochloric acid in dioxane, a solution of hydrochloric acid in methanol, a solution of hydrochloric acid in ethyl acetate, or trifluoroacetic acid to give compound (xvi).

[Process 2]

Compound (xviii) may be prepared by a reaction of compound (xvi) and an acid halide compound (xvii) wherein R¹² is halogen, in the presence of a base such as triethylamine or diisopropylethylamine in a solvent such as THF or dioxane. Dimethylaminopyridine may be added, if necessary.

Also, compound (xvi) is reacted with carboxylic acid (xvii) wherein R¹² is hydroxy, in a solvent such as THF or DMF, in the presence of a condensing agent such as 1-ethyl-3-(3-dimethylaminopropyl carbodiimide hydrochloride and a base such as triethylamine or diisopropylethylamine, and 1-hydroxybenzotriazole to give compound (xviii).

[Method E]

wherein, R¹³ is substituted or unsubstituted lower alkyl; u is an integer of 1 to 4; all other variables are as defined above.

[Process 1]

Compound (xx) may be prepared by the reaction of compound (x) obtained by Method B and compound (xix) in a solvent such as DMF, NMP or THF, in the presence of a base such as DBU, potassium t-butoxide or sodium hydride at temperature of 0° C. to 80° C., preferably 30° C. to 50° C.

[Process 2]

Compound (xxi) may be prepared by the reaction of compound (xx) and compound (vii) in a solvent such as t-butanol, isopropanol, ethanol or acetonitrile, in the presence of an acid such as formic acid, acetic acid or metanesulfonic acid at reflux temperature.

[Process 3]

Compound (xxii) may be prepared by the reaction of compound (xxi) and a reagent such as aqueous lithium hydroxide, aqueous sodium hydroxide or aqueous potassium hydroxide, in a solvent such as methanol, ethanol or a mixed solvent thereof with THF, dioxane, and the like.

[Method F]

wherein, R¹⁴ is substituted or unsubstituted lower alkyl; R¹⁵ and R¹⁶ are each independently substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl alkyl, substituted or unsubstituted heteroaryl alkyl, substituted or unsubstituted lower alkenyl, substituted or unsubstituted lower alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted acyl, substituted or unsubstituted a non-aromatic heterocyclic group, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; u is an integer of 1 to 4; all other variables are as defined above.

[Process 1]

Compound (xxiv) may be prepared by the reaction of compound (xxiii) obtained by Method A or B and aqueous lithium hydroxide, aqueous sodium hydroxide or aqueous potassium hydroxide, in a solvent such as methanol, ethanol or a mixed thereof solvent with THF, dioxane and the like.

[Process 2]

Compound (xxiv) is reacted with compound (xxv) in a solvent such as THF, DMF or NMP, in the presence of a condensing agent such as 1-hydroxybenzotriazole, HOAt, 1-ethyl-3-(3-dimethylamiknopropyl)carbodiimide hydrochloride, HATU or PyBOP, and a base such as triethylamine or diisopropylethylamine to give compound (xxvi).

[Method G]

wherein, Pg¹ is an appropriate hydroxy protecting group; all other variables are as defined above.

[Process 1]

Compound (xxvii) may be prepared by the reaction of compound (x) obtained by Method B and a halogenating agent such as phosphorous oxychloride or phosphorous oxybromide, without solvent or in a solvent such as toluene or tetrahydrofuran at temperature of 0° C. to 100° C., preferably 40° C. to 60° C.

[Process 2]

To a mixture of alcohol (xv) such as 2-(tetrahydro-2H-pyran-2-yloxy)ethanol, where the other hydroxy group is protected, in a solvent such as THF, dioxane or DMF, is added a base, such as sodium hydride or potassium t-butoxide, and the resulting mixture is reacted with compound (xv) to give compound (xxviii).

[Process 3]

Compound (xxix) may be prepared by the reaction of compound (xxviii) and an acid such as hydrochloric acid, p-toluenesulfonic acid or a hydrate thereof, or p-toluenesulfonic acid pyridinium salt, in a solvent such as methanol.

[Method H]

wherein, R⁷ is substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl alkyl, substituted or unsubstituted heteroaryl alkyl, substituted or unsubstituted lower alkenyl, substituted or unsubstituted lower alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted acyl, substituted or unsubstituted a non-aromatic heterocyclic group, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; all other variables are as defined above.

[Process 1]

Compound (xxxi) may be prepared by the reaction of compound (xxvii) obtained by Method G and compound (xxx) in a solvent such as THF or dioxane.

[Method I]

wherein all variables are as defined above.

[Process 1]

Compound (xxvii) obtained by Method G in a solvent such as THF or dioxane, in the presence of a base such as sodium hydride is reacted with compound (xxxii) to give compound (xxxiii).

[Method J]

wherein, R¹⁸ is substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl; Q is dihydroxyborane, dialkoxyborane or dialkylborane,

and all other variants are as defined above.

Compound (xxxiv) may be prepared by the reaction of compound (xxvii) obtained by Method G and compound (xxxiii) in a solvent such as THF or dioxane, in the presence a palladium catalyst and an aqueous potassium carbonate, aqueous cesium carbonate or aqueous sodium carbonate, at temperature of 50° C. to reflux temperature, preferably reflux temperature or 120° C. to 200° C., preferably 130° C. to 150° C. under microwave radiation.

[Method K]

wherein, R¹⁹ is substituted or unsubstituted alkyl; v is an integer of 0 to 4; all other variables are as defined above.

A mixture of compound (xxxv) in a mixed solvent is hydrolyzed with a base such as sodium hydroxide or lithium hydroxide to give compound (xxxvi). In the above step, ethers such as dioxane, THF or DME, alcohols such as ethanol or methanol, DMF, DMA, DMSO or NMP is mixed with water as a mixed solvent. The room temperature is preferable. When the progress of the reaction is slow, the reaction temperature may be raised further.

[Process 2]

Compound (xxxvi) is solved in an alcohol such as methanol or ethanol, and the solution is applied for a catalytic reduction by using a hydrogenation reactor (e.g., H-Cube (10% Pt-C, H2=1 atm)) or a metallic catalyst such as palladium-carbon, platinum oxide or chlorotris(triphenylphosphine)rhodium(I) to give compound (xxxvii).

[Method L]

wherein the variables are as defined above.

[Process 1]

The mixture of compound (x) obtained by Method B and alcohol (xxxviii) in a solvent such as THF or dioxane, is reacted with triphenylphosphine or the like and diethyl azodicarboxylate or the like to give compound (ixl).

[Process 2]

Compound (II) may be prepared by the reaction of compound (ixl) and compound (vi) in the presence of an acid such as formic acid or acetic acid at reflux temperature.

The chiral compound (II) may be prepared by using chiral alcohol (xxxviii).

The compound (I) of the invention includes but is not limited to all possible isomers and racemates. For example, the compound (I) of the invention includes tautomers represented by formula:

In addition, one or more hydrogen, carbon or other atoms of a compound of Formula (I) can be replaced by an isotope of the hydrogen, carbon or other atoms. Compounds of Formula (I) include all radiolabeled forms of compounds of Formula (I) “radiolabeled,” “radiolabeled form”, and the like of a compound of Formula I, each of which is encompassed by the invention, is useful as a research and/or diagnostic tool in metabolism pharmacokinetic studies and in binding assays.

Examples of isotopes that can be incorporated into a compound of Formula (I) of the invention include isotopes of hydrogen, carbon, nitrogen, oxygen, phosphorous, sulfur, fluorine and chlorine, such as ²H, ³H, ¹³C, ¹⁴C, ¹⁵N, ¹⁸O, ¹⁷O, ³¹P, ³²P, ³⁵S, ¹⁸F, and ³⁶Cl, respectively. Radiolabeled compounds of the invention can be prepared by methods known in the art. For example, tritiated compounds of Formula (I) can be prepared by introducing tritium into the particular compound of Formula (I), for example, by catalytic dehalogenation with tritium. This method may include reacting a suitably halogen-substituted precursor of a compound of Formula (I) with tritium gas in the presence of a suitable catalyst, for example, Pd/C, in the presence or absence of a base. Other suitable methods for preparing tritiated compounds can be found in Filer, “The Preparation and Characterization of Tritiated Neurochemicals,” Chapter 6, pp. 155-192 in Isotopes in the Physical and Biomedical Sciences, Vol. 1, Labeled Compounds (Part A) (1987). ¹⁴C-labeled compounds can be prepared by employing starting materials having a ¹⁴C carbon.

Also, the compounds of the invention represented above by the general formula (I) or pharmaceutically acceptable salts thereof can be prepared in a form of hydrate or solvate thereof by published methods. Preferable solvate includes solvates with acetone, 2-butanol, 2-propanol, ethanol, ethyl acetate, tetrahydrofuran, diethylether, etc. For example, such solvate includes hydrate or solvate (For example, with ethanol, etc.) which has non-toxicity and solubility.

The compound of the invention represented above by the general formula (I) has an antagonizing action on P2X₃ and/or P2X_(2/3) receptor, and therefore, is useful as a therapeutic agent for diseases associated with a P2X₃ and/or P2X_(2/3) receptor. Since P2X₃ and/or P2X_(2/3) receptor is believed to associate with pain and diseases in urinary system (Nature 407, 26, 1011-1015 (2000), Nature, Vol. 407, No. 26, 1015-1017 (2000), Non-Patent Document 1, Non-Patent Document 2, etc.), the compound of the invention is useful in the treatment of, alleviation of symptoms or prevention of diseases, such as for example, pain associated with rheumatoid arthritis, pain associated with osteoarthritis, headache, migraine, orofacial pain, toothache, glossagra, pain associated with temporomandibular arthrosis, trigeminal neuralgia, shoulder pain, pain associated with hernia of intervertebral disk, pain associated with cervical spondylosis deformans, pain associated with spinal canal stenosis, pain associated with thoracic outlet syndrome, pain associated with traumatic brachial plexus injury syndrome, pain associated with shoulder-hand syndrome, pain associated with whiplash injury, chest pain, abdominal pain, colic pain, pain associated with cholelithiasis, pain associated with pancreatitis, pain associated with urinary calculosis, pain associated with irritable bowel syndrome, lumbar backache, sciatica, pain associated with bone fracture, pain associated with osteoporosis, joint pain, pain associated with gout, pain associated with cauda equina syndrome, pain associated with ankylosing spondylitis, sore muscle, pain associated with painful spasm, pain associated with myofascial pain syndrome, pain associated with fibromyalgia syndrome, pain associated with arteriosclerosis obliterans, pain associated with Buerger's disease, pain associated with Raynaud's phenomenon, pain associated with zoster, causalgic pain, pain associated with entrapment neuropathy, pain associated with carpal canal syndrome, pain associated with diabetes, pain associated with Guillain-Barre syndrome, pain associated with Hansen's disease, pain associated with drug therapy, pain associated with radiation therapy, pain associated with cord injury, pain associated with syringomyelia, pain associated with stroke, thalamic pain, pain associated with deafferentation, sympathetically-maintained pain, pain associated with ABC syndrome, pain associated with multiple sclerosis, pain associated with skin disease, cancer pain, postoperative pain, pain associated with injury, pain associated with gangrene, pain associated with somatoform disorder, pain associated with somatization disorder, pain associated with depression, pain associated with Parkinson's disease, knee joint pain, pain associated with arthritis, neuropathic pain such as menstrual pain, intermenstrual pain, labor pain, etc., inflammatory pain, nociceptive pain, psychogenic pain, and overactive bladder, incontinence, pollakiuria, urinary urgency, cystatrophia, prostatic hypertrophy, prostatitis, prostate pain, detrusor hyperreflesxia, dysuria, nervous pollakiuria, chronic prostatitis, chronic cystitis, etc.

The compound of the invention can be a drug with reduced side-effect such as effect on motor function because it has a high affinity for ATP receptor, especially P2X₃ receptor, and also has high subtype selectivity and high selectivity for other receptors. Also, the compound of the invention is advantageous because of its high stability and high oral absorptivity, good bioavailability, low clearance, long half-life, prolonged duration of action, and/or low activity of hepatic enzyme inhibition, etc.

In another embodiment, the invention provides a pharmaceutical composition comprising an effective amount of the compound of the invention, in combination with a pharmaceutically acceptable carrier

For use of the compound of the invention as a medicament, a pharmaceutical composition can be prepared according to conventional methods, using pharmaceutically acceptable carriers well known in the art, such as excipients, binders, disintegrants, lubricants, colourants, flavors, surfactants, etc.

For the pharmaceutical composition of the invention to be administered in the treatment of mammals including human, an appropriate unit dosage form may be selected depending on the purpose of the treatment and the route of administration. Specifically, such unit dosage form includes oral formulations such as tablet, coated tablet, powder, granule, capsule, liquid, pill, suspension, emulsion, etc., and parenteral formulations such as injectable solution, suppository, ointment, patch, aerosol, etc. Such unit dosage form can be formulated according to methods well known in the art.

The amount of the compound in a formulation can be varied depending on its dosage form, route for administration, dosing regimen, etc.

Means for administration of the pharmaceutical composition may be selected depending on dosage form, age, sex, body weight, severity of the disease, and other factors, etc., and route for administration can be selected from various routes such as oral, subcutaneous, transdermal, rectal, intranasal, buccal, etc.

Dose of the compound of the invention in a pharmaceutical composition of the invention can be determined depending on the choice of route for administration, age, sex, body weight, severity of the disease, the compound to be administered, and other factors, etc., and can be generally from 0.05 to 1000 mg/kg/day, preferably from 0.1 to 10 mg/kg/day, for oral administration to adults. For parenteral administration, dose can be varied widely depending on its route but generally from 0.005 to 100 mg/kg/day, preferably from 0.01 to 1 mg/kg/day. Such pharmaceutical composition of the invention may be administered once a day or in several times at a divided dosage in a day.

Embodiments of the compound of the invention include compounds represented by the general formula (IV) and the general formula (V):

wherein each substituent is as shown below:

TABLE 1 Rp Rp1 Et Rp2 Pr Rp3 i-Pr Rp4 Bu Rp5 t-Bu Rp6 c-PrCH2 Rp7 HO(CH2)2 Rp8 HO(CH2)3 Rp9 (HOCH2)2CH Rp10 (HOCH2)2CHCH2 Rp11 (HOCH2)2C(Me)CH2 Rp12 EtOCOCH2 Rp13 EtOCO(CH2)2 Rp14 EtOCOCF2CH2 Rp15 HOCOCH2 Rp16 HOCO(CH2)2 Rp17 HOCOCF2CH2 Rp18 Ph—CH2 Rp19 3-pyridylmethyl Rp20 NCCH2 Rp21 NC(CH2)2 Rp22 allyl Rp23 propargyl Rp24 H2N(CH2)2 Rp25 Ms2N(CH2)2 Rp26 AcHN(CH2)2 Rp27 (morpholino)methyl Rp28 2-(morpholino)ethyl Rp29 (piperidino)methyl Rp30 2-(piperidino)ethyl Rp31 HOCOC(Me)2CH2 Rp32 (1-hydroxycarbonyl-c-propyl) methyl Rp33 HOCOC(CH2)3 Rp34 HOCOC(Me)2(CH2)2 Rp35 H2NCOCH2 Rp36 MeNHCOCH2 Rp37 HOCH2NHCOCH2 Rp38 HOCOCH2NHCOCH2 Rp39 HOCOCH(Me)CH2 Rp40 HOCOCH2CHCMe) Rp41 (2-HOCO)PhCH2 Rp42 (3-HOCO)PhCH2 Rp43 (4-HOCO)PhCH2

TABLE 2 Rq Rq1 Ph Rq2 4-Me—Ph Rq3 4-MeO—Ph Rq4 4-F—Ph Rq5 4-CI—Ph Rq6 4-Br—Ph Rq7 3,4-Cl₂—Ph Rq8 5-Cl-2-pyridyl Rcj9 6-Cl-3-pyridyl Rq10 c-hexyl Rq11 3-F-4-Cl—Ph Rq12 c-heptyl

TABLE 3 Rr Rr1 3-Br—Ph Rr2 3-CF₃—Ph Rr3 4-EtO—Ph Rr4 4-i-PrO—Ph Rr5 4-PhO—Ph Rr6 4-CHF₂O—Ph Rr7 3-F-4-MeO—Ph Rr8 3-F-4-EtO—Ph Rr9 3-F-4-PrO—Ph Rr10 3-F-4-i-PrO—Ph Rr11 3-F-4-CHF₂O—Ph Rr12 3-Cl-4-MeO—Ph Rr13 3-Cl-4-EtO—Ph Rr14 3-Cl-4-PrO—Ph Rr15 3-Cl-4-i-PrO—Ph Rr16 3-Cl-4-CHF₂O—Ph Rr17 3-Me-4-EtO—Ph Rr18 3-Me-4-PrO—Ph Rr19 3-Me-4-i-PrO—Ph Rr20 2-Me-benzofuran-5-yl Rr21 3-MeS Rr22 3,4-Cl2 In the above Tables, Ac indicates acetyl, Ms indicates mesyl, Me indicates methyl, Et indicates ethyl, Pr indicates propyl, i-Pr indicates isopropyl, Bu indicates n-butyl, t-Bu indicates tert-butyl, c-Pr indicates cyclopropyl, cBu indicates cyclobutyl, cPent indicates cyclopentyl, cHex indicates cyclohexyl and Ph indicates phenyl

The compounds represented by the following (R_(p), R_(q), R_(r)) which show the combination of R^(p), R^(q) and R^(r) are exemplified:

(Rp,Rq,Rr)=(Rp1,Rq1,Rr1),(Rp1,Rq1,Rr2),(Rp1,Rq1,Rr3),(Rp1,Rq1,Rr4),(Rp1,Rq1,Rr5),(Rp1,Rq1,Rr6),(Rp1,Rq1,Rr7),(Rp1,Rq1,Rr8),(Rp1,Rq1,Rr9),(Rp1,Rq1,Rr10),(Rp1,Rq1,Rr11),(Rp1,Rq1,Rr12),(Rp1,Rq1,Rr13),(Rp1,Rq1,Rr14),(Rp1,Rq1,Rr15),(Rp1,Rq1, Rr16),(Rp1,Rq1,Rr17),(Rp1,Rq1,Rr18),(Rp1,Rq1,Rr19),(Rp1,Rq1,Rr20),(Rp1,Rq1,Rr21), (Rp1,Rq1,Rr22),(Rp1,Rq2,Rr1),(Rp1,Rq2,Rr2),(Rp1,Rq2,Rr3),(Rp1,Rq2,Rr4),(Rp1,Rq2,Rr5),(Rp1,Rq2,Rr6),(Rp1,Rq2,Rr7),(Rp1,Rq2,Rr8),(Rp1,Rq2,Rr9),(Rp1,Rq2,Rr10),(Rp1,Rq2,Rr11),(Rp1,Rq2,Rr12),(Rp1,Rq2,Rr13),(Rp1,Rq2,Rr14),(Rp1,Rq2,Rr15),(Rp1,Rq2, Rr16),(Rp1,Rq2,Rr17),(Rp1,Rq2,Rr18),(Rp1,Rq2,Rr19),(Rp1,Rq2,Rr20),(Rp1,Rq2,Rr21), (Rp1,Rq2,Rr22),(Rp1,Rq3,Rr1),(Rp1,Rq3,Rr2),(Rp1,Rq3,Rr3),(Rp1,Rq3,Rr4),(Rp1,Rq3,Rr5),(Rp1,Rq3,Rr6),(Rp1,Rq3,Rr7),(Rp1,Rq3,Rr8),(Rp1,Rq3,Rr9),(Rp1,Rq3,Rr10),(Rp1,Rq3,Rr11),(Rp1,Rq3,Rr12),(Rp1,Rq3,Rr13),(Rp1,Rq3,Rr14),(Rp1,Rq3,Rr15),(Rp1,Rq3, Rr16),(Rp1,Rq3,Rr17),(Rp1,Rq3,Rr18),(Rp1,Rq3,Rr19),(Rp1,Rq3,Rr20),(Rp1,Rq3,Rr21), (Rp1,Rq3,Rr22),(Rp1,Rq4,Rr1),(Rp1,Rq4,Rr2),(Rp1,Rq4,Rr3),(Rp1,Rq4,Rr4),(Rp1,Rq4,Rr5),(Rp1,Rq4,Rr6),(Rp1,Rq4,Rr7),(Rp1,Rq4,Rr8),(Rp1,Rq4,Rr9),(Rp1,Rq4,Rr10),(Rp1,Rq4,Rr11),(Rp1,Rq4,Rr12),(Rp1,Rq4,Rr13),(Rp1,Rq4,Rr14),(Rp1,Rq4,Rr15),(Rp1,Rq4, Rr16),(Rp1,Rq4,Rr17),(Rp1,Rq4,Rr18),(Rp1,Rq4,Rr19),(Rp1,Rq4,Rr20),(Rp1,Rq4,Rr21), (Rp1,Rq4,Rr22),(Rp1,Rq5,Rr1),(Rp1,Rq5,Rr2),(Rp1,Rq5,Rr3),(Rp1,Rq5,Rr4),(Rp1,Rq5,Rr5),(Rp1,Rq5,Rr6),(Rp1,Rq5,Rr7),(Rp1, Rq5,Rr8),(Rp1,Rq5,Rr9),(Rp1,Rq5,Rr10),(Rp1,Rq5,Rr11),(Rp1,Rq5,Rr12),(Rp1,Rq5,Rr13),(Rp1,Rq5,Rr14),(Rp1,Rq5,Rr15),(Rp1,Rq5, Rr16),(Rp1,Rq5,Rr17),(Rp1,Rq5,Rr18),(Rp1,Rq5,Rr19),(Rp1,Rq5,Rr20),(Rp1,Rq5,Rr21), (Rp1,Rq5,Rr22),(Rp1,Rq6,Rr1),(Rp1,Rq6,Rr2),(Rp1,Rq6,Rr3),(Rp1,Rq6,Rr4),(Rp1,Rq6,Rr5),(Rp1,Rq6,Rr6),(Rp1,Rq6,Rr7),(Rp1,Rq6,Rr8),(Rp1,Rq6,Rr9),(Rp1,Rq6,Rr10),(Rp1,Rq6,Rr11),(Rp1,Rq6,Rr12),(Rp1,Rq6,Rr13),(Rp1,Rq6,Rr14),(Rp1,Rq6,Rr15),(Rp1,Rq6, Rr16),(Rp1,Rq6,Rr17),(Rp1,Rq6,Rr18),(Rp1,Rq6,Rr19),(Rp1,Rq6,Rr20),(Rp1,Rq6,Rr21), (Rp1,Rq6,Rr22),(Rp1,Rq7,Rr1),(Rp1,Rq7,Rr2),(Rp1,Rq7,Rr3),(Rp1,Rq7,Rr4),(Rp1,Rq7,Rr5),(Rp1,Rq7,Rr6),(Rp1,Rq7,Rr7),(Rp1,Rq7,Rr8),(Rp1,Rq7,Rr9),(Rp1,Rq7,Rr10),(Rp1,Rq7,Rr11),(Rp1,Rq7,Rr12),(Rp1,Rq7,Rr13),(Rp1,Rq7,Rr14),(Rp1,Rq7,Rr15),(Rp1,Rq7, Rr16),(Rp1,Rq7,Rr17),(Rp1,Rq7,Rr18),(Rp1,Rq7,Rr19),(Rp1,Rq7,Rr20),(Rp1,Rq7,Rr21), (Rp1,Rq7,Rr22),(Rp1,Rq8,Rr1),(Rp1,Rq8,Rr2),(Rp1,Rq8,Rr3),(Rp1,Rq8,Rr4),(Rp1,Rq8,Rr5),(Rp1,Rq8,Rr6),(Rp1,Rq8,Rr7),(Rp1,Rq8,Rr8),(Rp1,Rq8,Rr9),(Rp1,Rq8,Rr10),(Rp1,Rq8,Rr11),(Rp1,Rq8,Rr12),(Rp1,Rq8,Rr13),(Rp1,Rq8,Rr14),(Rp1,Rq8,Rr15),(Rp1,Rq8 Rr16),(Rp1,Rq8,Rr17),(Rp1,Rq8,Rr18),(Rp1,Rq8,Rr19),(Rp1,Rq8,Rr20),(Rp1,Rq8,Rr21), (Rp1,Rq8,Rr22),(Rp1,Rq9,Rr11),(Rp1,Rq9,Rr2),(Rp1,Rq9,Rr3),(Rp1,Rq9,Rr4),(Rp1,Rq9,Rr5),(Rp1,Rq9,Rr6),(Rp1,Rq9, Rr7),(Rp1,Rq9,Rr8),(Rp1,Rq9,Rr9),(Rp1,Rq9,Rr10),(Rp1,Rq9,Rr1),(Rp1,Rq9,Rr12),(Rp1,Rq9,Rr13),(Rp1,Rq9,Rr14),(Rp1,Rq9,Rr15),(Rp1,Rq9 Rr16),(Rp1,Rq9,Rr17),(Rp1,Rq9,Rr18),(Rp1,Rq9,Rr19),(Rp1,Rq9,Rr20),(Rp1,Rq9,Rr21), (Rp1,Rq9,Rr22),(Rp1,Rq10,Rr1),(Rp1,Rq1,Rr2),(Rp1,Rq1,Rr3),(Rp1,Rq1,Rr4),(Rp1,Rq1,Rr5),(Rp1,Rq10,Rr6),(Rp1,Rq10,Rr7),(Rp1,Rq10,Rr8),(Rp1,Rq10,Rr9),(Rp1,Rq10, Rr10),(Rp1,Rq10,Rr1),(Rp1,Rq1,Rr12),(Rp1,Rq10, Rr13),(Rp1,Rq10,Rr14),(Rp1,Rq10,Rr15),(Rp1,Rq1,Rr16),(Rp1,Rq1,Rr17),(Rp1,Rq10,Rr18),(Rp1,Rq10,Rr19),(Rp1,Rq10, Rr20),(Rp1,Rq10,Rr21),(Rp1,Rq10,Rr22),(Rp1,Rq11,Rr1),(Rp1,Rq11,Rr2),(Rp1,Rq11,Rr3),(Rp1,Rq1,Rr4),(Rp1,Rq1,Rr5),(Rp1,Rq1,Rr6),(Rp1,Rq1,Rr7),(Rp1,Rq11,Rr8),(Rp1,Rq11,Rr9),(Rp1,Rq11,Rr10),(Rp1,Rq11,Rr11),(Rp1,Rq11,Rr12),(Rp1,Rq11,Rr13), (Rp1,Rq11,Rr14),(Rp1,Rq11,Rr15),(Rp1,Rq11,Rr16),(Rp1,Rq11,Rr17),(Rp1,Rq11,Rr18),(Rp1,Rq11,Rr19),(Rp1,Rq11,Rr20),(Rp1,Rq11,Rr21),(Rp1,Rq11,Rr22),(Rp1,Rq12,Rr11),(Rp1,Rq12,Rr2),(Rp1,Rq12,Rr3),(Rp1,Rq12,Rr4),(Rp1,Rq12,Rr5),(Rp1,Rq12,Rr6), (Rp1,Rq12,Rr7),(Rp1,Rq12,Rr8),(Rp1,Rq12,Rr9),(Rp1,Rq12,Rr10),(Rp1,Rq12,Rr11),(Rp1,Rq12,Rr12),(Rp1,Rq12,Rr13),(Rp1,Rq12,Rr14),(Rp1,Rq12,Rr15),(Rp1,Rq12,Rr16),(Rp1,Rq12,Rr17),(Rp1,Rq12,Rr18),(Rp1,Rq12,Rr19),Rp1,Rq12,Rr20),(Rp1,Rq12,Rr21), (Rp1,Rq12,Rr22),(Rp2,Rq1,Rr1),(Rp2,Rq11,Rr2),(Rp2,Rq1,Rr3),(Rp2,Rq1,Rr4),(Rp2,Rq1, Rr5),(Rp2,Rq1,Rr6),(Rp2,Rq1,Rr7),(Rp2,Rq1,Rr8),(Rp2,Rq1,Rr9),(Rp2,Rq1,Rr10),(Rp2, Rq1,Rr1),(Rp2,Rq1,Rr12),(Rp2,Rq1,Rr13),(Rp2,Rq1,Rr14),(Rp2,Rq1,Rr15),(Rp2,Rq11, Rr16),(Rp2,Rq1,Rr17),(Rp2,Rq1,Rr18),(Rp2,Rq1,Rr9),(Rp2,Rq1,Rr2),(Rp2,Rq1,Rr21) (Rp2,Rq1,Rr22),(Rp2,Rq2,Rr1),(Rp2,Rq2,Rr2),(Rp2,Rq2,Rr3),(Rp2,Rq2,Rr4),(Rp2,Rq2, Rr5),(Rp2,Rq2,Rr6),(Rp2,Rq2,Rr7),(Rp2,Rq2,Rr8),(Rp2,Rq2,Rr9),(Rp2,Rq2,Rr10),(Rp2, Rq2,Rr11),(Rp2,Rq2,Rr12),(Rp2,Rq2,Rr13),(Rp2,Rq2,Rr14),(Rp2,Rq2,Rr15),(Rp2,Rq2, Rr16),(Rp2,Rq2,Rr17),(Rp2,Rq2,Rr18),(Rp2,Rq2,Rr19),(Rp2,Rq2,Rr20),(Rp2,Rq2,Rr21) (Rp2,Rq2,Rr22),(Rp2,Rq3,Rr1),(Rp2,Rq3,Rr2),(Rp2,Rq3,Rr3),(Rp2,Rq3,Rr4),(Rp2,Rq3, Rr5),(Rp2,Rq3,Rr6),(Rp2,Rq3,Rr7),(Rp2,Rq3,Rr8),(Rp2,Rq3,Rr9),(Rp2,Rq3,Rr10),(Rp2, Rq3,Rr11),(Rp2,Rq3,Rr12),(Rp2,Rq3,Rr13),(Rp2,Rq3,Rr14),(Rp2,Rq3,Rr5),(Rp2,Rq3, Rr16),(Rp2,Rq3,Rr17),(Rp2,Rq3,Rr18),(Rp2,Rq3,Rr19),(Rp2,Rq3,Rr20),(Rp2,Rq3,Rr21), (Rp2,Rq3,Rr22),(Rp2,Rq4,Rr1),(Rp2,Rq4,Rr2),(Rp2,Rq4,Rr3),(Rp2,Rq4,Rr4),(Rp2,Rq4, Rr5),(Rp2,Rq4,Rr6),(Rp2,Rq4,Rr7),(Rp2,Rq4,Rr8),(Rp2,Rq4,Rr9),(Rp2,Rq4,Rr10),(Rp2, Rq4,Rr11),(Rp2,Rq4,Rr12),(Rp2,Rq4,Rr13),(Rp2,Rq4,Rr14),(Rp2,Rq4,Rr15),(Rp2,Rq4, Rr16),(Rp2,Rq4,Rr17),(Rp2,Rq4,Rr18),(Rp2,Rq4,Rr19),(Rp2,Rq4,Rr20),(Rp2,Rq4,Rr21), (Rp2,Rq4,Rr22),(Rp2,Rq5,Rr1),(Rp2,Rq5,Rr2),(Rp2,Rq5,Rr3),(Rp2,Rq5,Rr4),(Rp2,Rq5, Rr5),(Rp2,Rq5,Rr6),(Rp2,Rq5,Rr7),(Rp2,Rq5,Rr8),(Rp2,Rq5,Rr9),(Rp2,Rq5,Rr10),(Rp2, Rq5,Rr11),(Rp2,Rq5,Rr12),(Rp2,Rq5,Rr13),(Rp2,Rq5,Rr14),(Rp2,Rq5,Rr15),(Rp2,Rq5, Rr16),(Rp2,Rq5,Rr17),(Rp2,Rq5,Rr18),(Rp2,Rq5,Rr19),(Rp2,Rq5,Rr20),(Rp2,Rq5,Rr21), (Rp2,Rq5,Rr22),(Rp2,Rq6,Rr1),(Rp2,Rq6,Rr2),(Rp2,Rq6,Rr3),(Rp2,Rq6,Rr4),(Rp2,Rq6, Rr5),(Rp2,Rq6,Rr6),(Rp2,Rq6,Rr7),(Rp2,Rq6,Rr8),(Rp2,Rq6,Rr9),(Rp2,Rq6,Rr10),(Rp2, Rq6,Rr11),(Rp2,Rq6,Rr12),(Rp2,Rq6,Rr13),(Rp2,Rq6,Rr14),(Rp2,Rq6,Rr15),(Rp2,Rq6, Rr16),(Rp2,Rq6,Rr17),(Rp2,Rq6,Rr18),(Rp2,Rq6,Rr19),(Rp2,Rq6,Rr20),(Rp2,Rq6,Rr21), (Rp2,Rq6,Rr22),(Rp2,Rq7,Rr1),(Rp2,Rq7,Rr2),(Rp2,Rq7,Rr3),(Rp2,Rq7,Rr4),(Rp2,Rq7, Rr5),(Rp2,Rq7,Rr6),(Rp2,Rq7,Rr7),(Rp2,Rq7,Rr8),(Rp2,Rq7,Rr9),(Rp2,Rq7,Rr10),(Rp2, Rq7,Rr1),(Rp2,Rq7,Rr12),(Rp2,Rq7,Rr13),(Rp2,Rq7,Rr14),(Rp2,Rq7,Rr15),(Rp2,Rq7, Rr16),(Rp2,Rq7,Rr17),(Rp2,Rq7,Rr18),(Rp2,Rq7,Rr19),(Rp2,Rq7,Rr20),(Rp2,Rq7,Rr21), (Rp2,Rq7,Rr22),(Rp2,Rq8,Rr1),(Rp2,Rq8,Rr2),(Rp2,Rq8,Rr3),(Rp2,Rq8,Rr4),(Rp2,Rq8, Rr5),(Rp2,Rq8,Rr6),(Rp2,Rq8,Rr7),(Rp2,Rq8,Rr8),(Rp2,Rq8,Rr9),(Rp2,Rq8,Rr10),(Rp2, Rq8,Rr11),(Rp2,Rq8,Rr12),(Rp2,Rq8,Rr13),(Rp2,Rq8,Rr14),(Rp2,Rq8,Rr15),(Rp2,Rq8, Rr16),(Rp2,Rq8,Rr17),(Rp2,Rq8,Rr18),(Rp2,Rq8,Rr19),(Rp2,Rq8,Rr20),(Rp2,Rq8,Rr21), (Rp2,Rq8,Rr22),(Rp2,Rq9,Rr1),(Rp2,Rq9,Rr2),(Rp2,Rq9,Rr3),(Rp2,Rq9,Rr4),(Rp2,Rq9, Rr5),(Rp2,Rq9,Rr6),(Rp2,Rq9,Rr7),(Rp2,Rq9,Rr8),(Rp2,Rq9,Rr9),(Rp2,Rq9,Rr10),(Rp2, Rq9,Rr11),(Rp2,Rq9,Rr12),(Rp2,Rq9,Rr13),(Rp2,Rq9,Rr14),(Rp2,Rq9,Rr15),(Rp2,Rq9, Rr16),(Rp2,Rq9,Rr17),(Rp2,Rq9,Rr18),(Rp2,Rq9,Rr19),(Rp2,Rq9,Rr20),(Rp2,Rq9,Rr21), (Rp2,Rq9,Rr22),(Rp2,Rq10,Rr1),(Rp2,Rq10,Rr2),(Rp2,Rq10,Rr3),(Rp2,Rq10,Rr4),(Rp2, Rq10,Rr5),(Rp2,Rq10,Rr6),(Rp2,Rq10,Rr7),(Rp2,Rq10,Rr8),(Rp2,Rq10,Rr9),(Rp2,Rq10, Rr10),(Rp2,Rq10,Rr1),(Rp2,Rq10,Rr12),(Rp2,Rq10,Rr13),(Rp2,Rq10,Rr14),(Rp2,Rq10, Rr15),(Rp2,Rq10,Rr16),(Rp2,Rq10,Rr17),(Rp2,Rq10,Rr18),(Rp2,Rq10,Rr19),(Rp2,Rq10,Rr20),(Rp2,Rq10,Rr21),(Rp2,Rq10,Rr22),(Rp2,Rq11,Rr1),(Rp2,Rq11,Rr2),(Rp2,Rq11, Rr3),(Rp2,Rq11,Rr4),(Rp2,Rq11,Rr5),(Rp2,Rq11,Rr6),(Rp2,Rq11,Rr7),(Rp2,Rq11,Rr8), (Rp2,Rq11,Rr9),(Rp2,Rq11,Rr10),(Rp2,Rq11,Rr11),(Rp2,Rq11,Rr12),(Rp2,Rq11,Rr13), (Rp2,Rq11,Rr14),(Rp2,Rq11,Rr15),(Rp2,Rq11,Rr16),(Rp2,Rq11,Rr17),(Rp2,Rq11,Rr18), (Rp2,Rq11,Rr19),(Rp2,Rq11,Rr20),(Rp2,Rq11,Rr21),(Rp2,Rq11,Rr22),(Rp2,Rq12,Rr1), (Rp2,Rq12,Rr2),(Rp2,Rq12,Rr3),(Rp2,Rq12,Rr4),(Rp2,Rq12,Rr5),(Rp2,Rq12,Rr6),(Rp2, Rq12,Rr7),(Rp2,Rq12,Rr8),(Rp2,Rq12,Rr9),(Rp2,Rq12,Rr10),(Rp2,Rq12,Rr11),(Rp2,Rq12,Rr12),(Rp2,Rq12,Rr13),(Rp2,Rq12,Rr14),(Rp2,Rq12,Rr15),(Rp2,Rq12,Rr16),(Rp2,Rq12,Rr17),(Rp2,Rq12,Rr18),(Rp2,Rq12,Rr19),(Rp2,Rq12,Rr20),(Rp2,Rq12,Rr21),(Rp2, Rq12,Rr22),(Rp3,Rq1,Rr1),(Rp3,Rq1,Rr2),(Rp3,Rq1,Rr3),(Rp3,Rq1,Rr4),(Rp3,Rq1,Rr5), (Rp3,Rq1,Rr6),(Rp3,Rq1,Rr7),(Rp3,Rq1,Rr8),(Rp3,Rq1,Rr9),(Rp3,Rq1,Rr10),(Rp3,Rq1, Rr1),(Rp3,Rq1,Rr12),(Rp3,Rq1,Rr13),(Rp3,Rq1,Rr14),(Rp3,Rq1,Rr15),(Rp3,Rq1,Rr16), (Rp3,Rq1,Rr17),(Rp3,Rq1,Rr18),(Rp3,Rq1,Rr19),(Rp3,Rq1,Rr20),(Rp3,Rq1,Rr21),(Rp3, Rq1,Rr22),(Rp3,Rq2,Rr1),(Rp3,Rq2,Rr2),(Rp3,Rq2,Rr3),(Rp3,Rq2,Rr4),(Rp3,Rq2,Rr5), (Rp3,Rq2,Rr6),(Rp3,Rq2,Rr7),(Rp3,Rq2,Rr8),(Rp3,Rq2,Rr9),(Rp3,Rq2,Rr10),(Rp3,Rq2, Rr11),(Rp3,Rq2,Rr12),(Rp3,Rq2,Rr13),(Rp3,Rq2,Rr14),(Rp3,Rq2,Rr15),(Rp3,Rq2,Rr16), (Rp3,Rq2,Rr17),(Rp3,Rq2,Rr18),(Rp3,Rq2,Rr19),(Rp3,Rq2,Rr20),(Rp3,Rq2,Rr21),(Rp3, 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(Rp41,Rq12,Rr1),(Rp41,Rq12,Rr2),(Rp41,Rq12,Rr3),(Rp41,Rq12,Rr4),(Rp41,Rq12,Rr5), (Rp41,Rq12,Rr6),(Rp41,Rq12,Rr7),(Rp41,Rq12,Rr8),(Rp41,Rq12,Rr9),(Rp41,Rq12,Rr10), (Rp41,Rq12,Rr1),(Rp41,Rq12,Rr12),(Rp41,Rq12,Rq13),(Rp41,Rq12,Rq14),(Rp41,Rq12,Rr15),(Rp41,Rq12,Rr16),(Rp41,Rq12,Rr17),(Rp41,Rq12,Rr18),(Rp41,Rq12,Rr19),(Rp41,Rq12,Rr20),(Rp41,Rq12,Rr21),(Rp41,Rq12,Rr22),(Rp42,Rq1,Rr1),(Rp42,Rq1,Rr2), (Rp42,Rq1,Rr3),(Rp42,Rq1,Rr4),(Rp42,Rq1,Rr5),(Rp42,Rq1,Rr6),(Rp42,Rq1,Rr7),(Rp42, Rq1,Rr8),(Rp42,Rq1,Rr9),(Rp42,Rq1,Rr10),(Rp42,Rq1,Rr11),(Rp42,Rq1,Rr12),(Rp42,Rq1,Rr13),(Rp42,Rq1,Rr14),(Rp42,Rq1,Rr15),(Rp42,Rq1,Rr16),(Rp42,Rq1,Rr17),(Rp42, Rq1,Rr18),(Rp42,Rq1,Rr19),(Rp42,Rq1,Rr20),(Rp42,Rq1,Rr21),(Rp42,Rq1,Rr22),(Rp42, Rq2,Rr1),(Rp42,Rq2,Rr2),(Rp42,Rq2,Rr3),(Rp42,Rq2,Rr4),(Rp42,Rq2,Rr5),(Rp42,Rq2, Rr6),(Rp42,Rq2,Rr7),(Rp42,Rq2,Rr8),(Rp42,Rq2,Rr9),(Rp42,Rq2,Rr10),(Rp42,Rq2,Rr11), (Rp42,Rq2,Rr12),(Rp42,Rq2,Rr13),(Rp42,Rq2,Rr14),(Rp42,Rq2,Rr15),(Rp42,Rq2,Rr16),(Rp42,Rq2,Rr17),(Rp42,Rq2,Rr18),(Rp42,Rq2,Rr19),(Rp42,Rq2,Rr20),(Rp42,Rq2,Rr21),(Rp42,Rq2,Rr22),(Rp42,Rq3,Rr1),(Rp42,Rq3,Rr2),(Rp42,Rq3,Rr3),(Rp42,Rq3,Rr4), (Rp42,Rq3,Rr5),(Rp42,Rq3,Rr6),(Rp42,Rq3,Rr7),(Rp42,Rq3,Rr8),(Rp42,Rq3,Rr9),(Rp42, Rq3,Rr10),(Rp42,Rq3,Rr11),(Rp42,Rq3,Rr12),(Rp42,Rq3,Rr13),(Rp42,Rq3,Rr14),(Rp42,Rq3,Rr15),(Rp42,Rq3,Rr16),(Rp42,Rq3,Rr17),(Rp42,Rq3,Rr18),(Rp42,Rq3,Rr19),(Rp42,Rq3,Rr20),(Rp42,Rq3,Rr21),(Rp42,Rq3,Rr22),(Rp42,Rq4,Rr1),(Rp42,Rq4,Rr2),(Rp42,Rq4,Rr3),(Rp42,Rq4,Rr4),(Rp42,Rq4,Rr5),(Rp42,Rq4,Rr6),(Rp42,Rq4,Rr7),(Rp42,Rq4,Rr8),(Rp42,Rq4,Rr9),(Rp42,Rq4,Rr10),(Rp42,Rq4,Rr11),(Rp42,Rq4,Rr12),(Rp42,Rq4, Rr13),(Rp42,Rq4,Rr14),(Rp42,Rq4,Rr15),(Rp42,Rq4,Rr16),(Rp42,Rq4,Rr17),(Rp42,Rq4, Rr18),(Rp42,Rq4,Rr19),(Rp42,Rq4,Rr20),(Rp42,Rq4,Rr21),(Rp42,Rq4,Rr22),(Rp42,Rq5,Rr1),(Rp42,Rq5,Rr2),(Rp42,Rq5,Rr3),(Rp42,Rq5,Rr4),(Rp42,Rq5,Rr5),(Rp42,Rq5,Rr6), (Rp42,Rq5,Rr7),(Rp42,Rq5,Rr8),(Rp42,Rq5,Rr9),(Rp42,Rq5,Rr10),(Rp42,Rq5,Rr11), (Rp42,Rq5,Rr12),(Rp42,Rq5,Rr13),(Rp42,Rq5,Rr14),(Rp42,Rq5,Rr15),(Rp42,Rq5,Rr16), (Rp42,Rq5,Rr17),(Rp42,Rq5,Rr18),(Rp42,Rq5,Rr19),(Rp42,Rq5,Rr20),(Rp42,Rq5,Rr21), (Rp42,Rq5,Rr22),(Rp42,Rq6,Rr1),(Rp42,Rq6,Rr2),(Rp42,Rq6,Rr3),(Rp42,Rq6,Rr4),(Rp42,Rq6,Rr5),(Rp42,Rq6,Rr6),(Rp42,Rq6,Rr7),(Rp42,Rq6,Rr8),(Rp42,Rq6,Rr9),(Rp42,Rq6,Rr10),(Rp42,Rq6,Rr11),(Rp42,Rq6,Rr12),(Rp42,Rq6,Rr13),(Rp42,Rq6,Rr14),(Rp42,Rq6,Rr15),(Rp42,Rq6,Rr16),(Rp42,Rq6,Rr17),(Rp42,Rq6,Rr18),(Rp42,Rq6,Rr19),(Rp42, Rq6,Rr20),(Rp42,Rq6,Rr21),(Rp42,Rq6,Rr22),(Rp42,Rq7,Rr1),(Rp42,Rq7,Rr2),(Rp42,Rq7,Rr3),(Rp42,Rq7,Rr4),(Rp42,Rq7,Rr5),(Rp42,Rq7,Rr6),(Rp42,Rq7,Rr7),(Rp42,Rq7,Rr8),(Rp42,Rq7,Rr9),(Rp42,Rq7,Rr10),(Rp42,Rq7,Rr11),(Rp42,Rq7,Rr12),(Rp42,Rq7,Rr13), (Rp42,Rq7,Rr14),(Rp42,Rq7,Rr15),(Rp42,Rq7,Rr16),(Rp42,Rq7,Rr17),(Rp42,Rq7,Rr18),(Rp42,Rq7,Rr19),(Rp42,Rq7,Rr20),(Rp42,Rq7,Rr21),(Rp42,Rq7,Rr22),(Rp42,Rq8,Rr1),(Rp42,Rq8,Rr2),(Rp42,Rq8,Rr3),(Rp42,Rq8,Rr4),(Rp42,Rq8,Rr5),(Rp42,Rq8,Rr6), (Rp42,Rq8,Rr7),(Rp42,Rq8,Rr8),(Rp42,Rq8,Rr9),(Rp42,Rq8,Rr10),(Rp42,Rq8,Rr1),(Rp42,Rq8,Rr12),(Rp42,Rq8,Rr13),(Rp42,Rq8,Rr14),(Rp42,Rq8,Rr15),(Rp42,Rq8,Rr16),(Rp42,Rq8,Rr17),(Rp42,Rq8,Rr18),(Rp42,Rq8,Rr19),(Rp42,Rq8,Rr20),(Rp42,Rq8,Rr21), (Rp42,Rq8,Rr22),(Rp42,Rq9,Rr1),(Rp42,Rq9,Rr2),(Rp42,Rq9,Rr3),(Rp42,Rq9,Rr4),(Rp42, Rq9,Rr5),(Rp42,Rq9,Rr6),(Rp42,Rq9,Rr7),(Rp42,Rq9,Rr8),(Rp42,Rq9,Rr9),(Rp42,Rq9, Rr10),(Rp42,Rq9,Rr11),(Rp42,Rq9,Rr12),(Rp42,Rq9,Rr13),(Rp42,Rq9,Rr14),(Rp42,Rq9,Rr15),(Rp42,Rq9,Rr16),(Rp42,Rq9,Rr17),(Rp42,Rq9,Rr18),(Rp42,Rq9,Rr19),(Rp42,Rq9,Rr20),(Rp42,Rq9,Rr21),(Rp42,Rq9,Rr22),(Rp42,Rq10,Rr1),(Rp42,Rq10,Rr2),(Rp42, Rq10,Rr3),(Rp42,Rq10,Rr4),(Rp42,Rq10,Rr5),(Rp42,Rq10,Rr6),(Rp42,Rq10,Rr7),(Rp42, Rq10,Rr8),(Rp42,Rq10,Rr9),(Rp42,Rq10,Rr10),(Rp42,Rq10,Rr11),(Rp42,Rq10,Rr12), (Rp42,Rq10,Rr13),(Rp42,Rq10,Rr14),(Rp42,Rq10,Rr15),(Rp42,Rq10,Rr16),(Rp42,Rq10, Rr17),(Rp42,Rq10,Rr18),(Rp42,Rq10,Rr19),(Rp42,Rq10,Rr20),(Rp42,Rq10,Rr21),(Rp42, Rq10,Rr22),(Rp42,Rq11,Rr1),(Rp42,Rq11,Rr2),(Rp42,Rq11,Rr3),(Rp42,Rq11,Rr4),(Rp42,Rq11,Rr5),(Rp42,Rq11,Rr6),(Rp42,Rq11,Rr7),(Rp42,Rq11,Rr8),(Rp42,Rq11,Rr9),(Rp42,Rq11,Rr10),(Rp42,Rq11,Rr11),(Rp42,Rq11,Rr12),(Rp42,Rq11,Rr13),(Rp42,Rq11,Rr14),(Rp42,Rq1,Rr15),(Rp42,Rq11,Rr16),(Rp42,Rq1,Rr17),(Rp42,Rq11,Rr18),(Rp42, Rq11,Rr19),(Rp42,Rq11,Rr20),(Rp42,Rq11,Rr21),(Rp42,Rq11,Rr22),(Rp42,Rq12,Rr1), (Rp42,Rq12,Rr2),(Rp42,Rq12,Rr3),(Rp42,Rq12,Rr4),(Rp42,Rq12,Rr5),(Rp42,Rq12,Rr6), (Rp42,Rq12,Rr7),(Rp42,Rq12,Rr8),(Rp42,Rq12,Rr9),(Rp42,Rq12,Rr10),(Rp42,Rq12,Rr11), (Rp42,Rq12,Rr12),(Rp42,Rq12,Rr13),(Rp42,Rq12,Rr14),(Rp42,Rq12,Rr15),(Rp42,Rq12,Rr16),(Rp42,Rq12,Rr17),(Rp42,Rq12,Rr18),(Rp42,Rq12,Rr19),(Rp42,Rq12,Rr20),(Rp42,Rq12,Rr21),(Rp42,Rq12,Rr22),(Rp43,Rq1,Rr1),(Rp43,Rq1,Rr2),(Rp43,Rq1,Rr3),(Rp43,Rq1,Rr4),(Rp43,Rq1,Rr5),(Rp43,Rq1,Rr6),(Rp43,Rq1,Rr7),(Rp43,Rq1,Rr8),(Rp43, Rq1,Rr9),(Rp43,Rq1,Rr10),(Rp43,Rq1,Rr11),(Rp43,Rq1,Rr12),(Rp43,Rq1,Rr13),(Rp43, Rq1,Rr14),(Rp43,Rq1,Rr15),(Rp43,Rq1,Rr16),(Rp43,Rq1,Rr17),(Rp43,Rq1,Rr18),(Rp43, Rq1,Rr19),(Rp43,Rq1,Rr20),(Rp43,Rq1,Rr21),(Rp43,Rq1,Rr22),(Rp43,Rq2,Rr1),(Rp43, Rq2,Rr2),(Rp43,Rq2,Rr3),(Rp43,Rq2,Rr4),(Rp43,Rq2,Rr5),(Rp43,Rq2,Rr6),(Rp43,Rq2, Rr7),(Rp43,Rq2,Rr8),(Rp43,Rq2,Rr9),(Rp43,Rq2,Rr10),(Rp43,Rq2,Rr11),(Rp43,Rq2,Rr12),(Rp43,Rq2,Rr13),(Rp43,Rq2,Rr14),(Rp43,Rq2,Rr15),(Rp43,Rq2,Rr16),(Rp43,Rq2,Rr17),(Rp43,Rq2,Rr18),(Rp43,Rq2,Rr19),(Rp43,Rq2,Rr20),(Rp43,Rq2,Rr21),(Rp43,Rq2, Rr22),(Rp43,Rq3,Rr1),(Rp43,Rq3,Rr2),(Rp43,Rq3,Rr3),(Rp43,Rq3,Rr4),(Rp43,Rq3,Rr5), (Rp43,Rq3,Rr6),(Rp43,Rq3,Rr7),(Rp43,Rq3,Rr8),(Rp43,Rq3,Rr9),(Rp43,Rq3,Rr10),(Rp43,Rq3,Rr11),(Rp43,Rq3,Rr12),(Rp43,Rq3,Rr13),(Rp43,Rq3,Rr14),(Rp43,Rq3,Rr15),(Rp43,Rq3,Rr16),(Rp43,Rq3,Rr7),(Rp43,Rq3,Rr18),(Rp43,Rq3,Rr19),(Rp43,Rq3,Rr20), (Rp43,Rq3,Rr21),(Rp43,Rq3,Rr22),(Rp43,Rq4,Rr1),(Rp43,Rq4,Rr2),(Rp43,Rq4,Rr3),(Rp43,Rq4,Rr4),(Rp43,Rq4,Rr5),(Rp43,Rq4,Rr6),(Rp43,Rq4,Rr7),(Rp43,Rq4,Rr8),(Rp43,Rq4,Rr9),(Rp43,Rq4,Rr10),(Rp43,Rq4,Rr11),(Rp43,Rq4,Rr12),(Rp43,Rq4,Rr13),(Rp43,Rq4,Rr14),(Rp43,Rq4,Rr15),(Rp43,Rq4,Rr16),(Rp43,Rq4,Rr17),(Rp43,Rq4,Rr18),(Rp43,Rq4,Rr19),(Rp43,Rq4,Rr20),(Rp43,Rq4,Rr21),(Rp43,Rq4,Rr22),(Rp43,Rq5,Rr1),(Rp43,Rq5,Rr2),(Rp43,Rq5,Rr3),(Rp43,Rq5,Rr4),(Rp43,Rq5,Rr5),(Rp43,Rq5,Rr6),(Rp43,Rq5,Rr7),(Rp43,Rq5,Rr8),(Rp43,Rq5,Rr9),(Rp43,Rq5,Rr10),(Rp43,Rq5,Rr11),(Rp43,Rq5,Rr12), (Rp43,Rq5,Rr13),(Rp43,Rq5,Rr14),(Rp43,Rq5,Rr15),(Rp43,Rq5,Rr16),(Rp43,Rq5,Rr17), (Rp43,Rq5,Rr18),(Rp43,Rq5,Rr19),(Rp43,Rq5,Rr20),(Rp43,Rq5,Rr21),(Rp43,Rq5,Rr22), (Rp43,Rq6,Rr1),(Rp43,Rq6,Rr2),(Rp43,Rq6,Rr3),(Rp43,Rq6,Rr4),(Rp43,Rq6,Rr5),(Rp43,Rq6,Rr6),(Rp43,Rq6,Rr7),(Rp43,Rq6,Rr8),(Rp43,Rq6,Rr9),(Rp43,Rq6,Rr10),(Rp43, Rq6,Rr11),(Rp43,Rq6,Rr12),(Rp43,Rq6,Rr13),(Rp43,Rq6,Rr14),(Rp43,Rq6,Rr15),(Rp43, Rq6,Rr16),(Rp43,Rq6,Rr17),(Rp43,Rq6,Rr18),(Rp43,Rq6,Rr19),(Rp43,Rq6,Rr20),(Rp43, Rq6,Rr21),(Rp43,Rq6,Rr22),(Rp43,Rq7,Rr1),(Rp43,Rq7,Rr2),(Rp43,Rq7,Rr3),(Rp43,Rq7,Rr4),(Rp43,Rq7,Rr5),(Rp43,Rq7,Rr6),(Rp43,Rq7,Rr7),(Rp43,Rq7,Rr8),(Rp43,Rq7,Rr9),(Rp43,Rq7,Rr10),(Rp43,Rq7,Rr1),(Rp43,Rq7,Rr12),(Rp43,Rq7,Rr13),(Rp43,Rq7,Rr14),(Rp43,Rq7,Rr15),(Rp43,Rq7,Rr16),(Rp43,Rq7,Rr17),(Rp43,Rq7,Rr18),(Rp43,Rq7,Rr19),(Rp43,Rq7,Rr20),(Rp43,Rq7,Rr21),(Rp43,Rq7,Rr22),(Rp43,Rq8,Rr1),(Rp43,Rq8,Rr2),(Rp43,Rq8,Rr3),(Rp43,Rq8,Rr4),(Rp43,Rq8,Rr5),(Rp43,Rq8,Rr6),(Rp43,Rq8,Rr7),(Rp43,Rq8,Rr8),(Rp43,Rq8,Rr9),(Rp43,Rq8,Rr10),(Rp43,Rq8,Rr11),(Rp43,Rq8,Rr12),(Rp43,Rq8,Rr13),(Rp43,Rq8,Rr14),(Rp43,Rq8,Rr15),(Rp43,Rq8,Rr16),(Rp43,Rq8,Rr17),(Rp43, Rq8,Rr18),(Rp43,Rq8,Rr19),(Rp43,Rq8,Rr20),(Rp43,Rq8,Rr21),(Rp43,Rq8,Rr22), (Rp43,Rq9,Rr1),(Rp43,Rq9,Rr2),(Rp43,Rq9,Rr3),(Rp43,Rq9,Rr4),(Rp43,Rq9,Rr5),(Rp43, Rq9,Rr6),(Rp43,Rq9,Rr7),(Rp43,Rq9,Rr8),(Rp43,Rq9,Rr9),(Rp43,Rq9,Rr10),(Rp43,Rq9, Rr11),(Rp43,Rq9,Rr12),(Rp43,Rq9,Rr13),(Rp43,Rq9,Rr14),(Rp43,Rq9,Rr15),(Rp43,Rq9,Rr16),(Rp43,Rq9,Rr7),(Rp43,Rq9,Rr18),(Rp43,Rq9,Rr19),(Rp43,Rq9,Rr20),(Rp43,Rq9,Rr21),(Rp43,Rq9,Rr22),(Rp43,Rq10,Rr1),(Rp43,Rq10,Rr2),(Rp43,Rq10,Rr3),(Rp43, Rq10,Rr4),(Rp43,Rq10,Rr5),(Rp43,Rq10,Rr6),(Rp43,Rq10,Rr7),(Rp43,Rq10,Rr8),(Rp43, Rq10,Rr9),(Rp43,Rq10,Rr10),(Rp43,Rq10,Rr11),(Rp43,Rq10,Rr12),(Rp43,Rq10,Rr13), (Rp43,Rq10,Rr14),(Rp43,Rq10,Rr15),(Rp43,Rq10,Rr16),(Rp43,Rq10,Rr17),(Rp43,Rq10, Rr18),(Rp43,Rq10,Rr19),(Rp43,Rq10,Rr20),(Rp43,Rq10,Rr21),(Rp43,Rq10,Rr22),(Rp43, Rq11,Rr1),(Rp43,Rq11,Rr2),(Rp43,Rq11,Rr3),(Rp43,Rq11,Rr4),(Rp43,Rq11,Rr5),(Rp43, Rq11,Rr6),(Rp43,Rq11,Rr7),(Rp43,Rq11,Rr8),(Rp43,Rq11,Rr9),(Rp43,Rq11,Rr10),(Rp43,Rq11,Rr11),(Rp43,Rq11,Rr12),(Rp43,Rq11,Rr13),(Rp43,Rq11,Rr14),(Rp43,Rq11,Rr15),(Rp43,Rq11,Rr16),(Rp43,Rq11,Rr17),(Rp43,Rq11,Rr18),(Rp43,Rq11,Rr19),(Rp43, Rq11,Rr20),(Rp43,Rq11,Rr21),(Rp43,Rq11,Rr22),(Rp43,Rq12,Rr1),(Rp43,Rq12,Rr2),(Rp43,Rq12,Rr3),(Rp43,Rq12,Rr4),(Rp43,Rq12,Rr5),(Rp43,Rq12,Rr6),(Rp43,Rq12,Rr7), (Rp43,Rq12,Rr8),(Rp43,Rq12,Rr9),(Rp43,Rq12,Rr10),(Rp43,Rq12,Rr11),(Rp43,Rq12,Rr12),(Rp43,Rq12,Rr13),(Rp43,Rq12,Rr14),(Rp43,Rq12,Rr15),(Rp43,Rq12,Rr16),(Rp43,Rq12,Rr17),(Rp43,Rq12,Rr18),(Rp43,Rq12,Rr19),(Rp43,Rq12,Rr20),(Rp43,Rq12,Rr21), (Rp43,Rq12,Rr22).

Following examples illustrate the present invention in more detail, however, the present invention is not limited to these examples. The meaning of each abbreviation is as follows.

Me: methyl

Et: ethyl

Bu: butyl

Ac: acetyl

TMS: tetramethylsilane

TMS-Cl: trimethylsilyl chloride

DMSO: dimethyl sulfoxide

DMF: dimethylformamide

THF: tetrahydrofuran

DBU: 1,8-diazabicyclo[5.4.0]undec-7-ene

NMP: N-methyl-2-pyrrolidone

HOAt: 1-hydroxy-7-azabenzotriazole

-   -   HATU: 2-(7-azabenzotriazol-1-yl)-1,1,3,3-tetramethyl uronium         hexafluorophosphate     -   PyBOP: benzotriazole-1-yl-oxy-trispyrrolidinophosphonium         hexafluorophosphate

rt: room temperature

Example 1 Preparation of 6-(ethylthio)-1-(4-fluorobenzyl)-3-isopropyl-1,3,5-triazine-2,4(1H,3H)-dione

To a mixture of S-ethylthiourea hybrobromide (14.8 g, 80 mmol) and DMF (75 mL) were added isopropylisocyanate (8.2 mL, 84 mmol) and DBU (12.6 mL, 84 mmol) under ice-cooling, and the resulting mixture was stirred under ice-cooling for 6 hours. 1,1′-carbonyldiimidazole (15.57 g, 96 mmol) and DBU (18.0 mL, 120 mmol) were added to the reaction mixture under ice-cooling, and the resulting mixture was stirred for 2 hours. Then, 2 mol/L hydrochloric acid (240 mL) was added to the reaction mixture under ice-cooling for about 50 minutes, and the precipitated solid was collected by filtration. The resulting solid was dissolved in ethyl acetate, and the mixture was dried over anhydrous magnesium sulphate and then concentrated in vacuo to give 6-(ethylthio)-3-isopropyl-1,3,5-triazine-2,4(1H,3H)-dione (12.29 g, yield: 71%) as light brown solid.

1H-NMR (δ ppm TMS/DMSO-d6): 1.27 (6H, t, J=7.2 Hz), 1.33 (6H, d, J=6.9 Hz), 3.05 (2H, q, J=7.2 Hz), 4.81 (1H, sept, J=6.9 Hz).

To a mixture of 6-(ethylthio)-3-isopropyl-1,3,5-triazine-2,4(1H,3H)-dione (4.09 g, 19 mmol), potassium carbonate (7.88 g, 57 mmol) and acetonitrile (80 mL) was added 4-fluorobenzylbromide (3.55 mL, 28.5 mmol), and the resulting mixture was stirred at reflux for 1.5 hours. Then, ice-water (20 mL) was poured into the reaction mixture, and the resulting mixture was extracted with ethyl acetate (10 mL). The extract was dried over anhydrous sodium sulphate, and then concentrated in vacuo. The resulting residue was purified on a silica gel column chromatography (ethyl acetate/hexane). The aimed compound was triturated with ethyl acetate and hexane to give 6-(ethylthio)-1-(4-fluorobenzyl)-3-isopropyl-1,3,5-triazine-2,4(1H,3H)-dione (5.96 g, yield: 97%) as colorless solid.

1H-NMR (δ ppm TMS/CDCl₃): 1.37 (3H, t, J=7.5 Hz), 1.47 (6H, d, J=6.9 Hz), 3.21 (2H, q, J=7.5 Hz), 5.02 (1H, sept, J=6.9), 5.06 (2H, s), 7.01-7.07 (2H, m), 7.31-7.36 (2H, m).

Example 2 Preparation of 1-(4-fluorobenzyl)-6-(4-isopropoxyphenylamino)-3-isopropyl-1,3,5-triazine-2,4(1H,3H)-dione

A mixture of 6-(ethylthio)-1-(4-fluorobenzyl)-3-isopropyl-1,3,5-triazine-2,4(1H,3H)-dione (0.323 g, 1 mmol), 4-isopropoxyaniline (0.907 g, 6 mmol) and 1-methyl-2-pyrolidone (1 mL) was heated at 230° C. for 30 min under microwave radiation. Then, water (10 mL) was poured into the reaction mixture, and the resulting mixture was extracted with ethyl acetate (10 mL). The extract was dried over anhydrous sodium sulphate, and then concentrated in vacuo. The resulting residue was purified on a silica gel column chromatography (ethyl acetate/hexane). The aimed compound was triturated with ethyl acetate and hexane to give 1-(4-fluorobenzyl)-6-(4-isopropoxyphenylamino)-3-isopropyl-1,3,5-triazine-2,4(1H,3H)-dione (0.21 g, yield: 51%) as colorless solid.

Melting point: 176-177° C.

1H-NMR (δ ppm TMS/CDCl₃): 1.34 (6H, d, J=6.0 Hz), 1.44 (6H, d, J=6.9 Hz), 4.49 (1H, sept, J=6.0 Hz), 4.96 (1H, sept, J=6.9 Hz), 5.18 (2H, s), 6.75-7.06 (6H, m), 7.53-7.57 (2H, m).

Example 3 Preparation of 6-(3-chloro-4-isopropoxyphenylamino)-1-(4-chlorobenzyl)-3-isopropyl-1,3, 5-triazine-2,4(1H,3H)-dione

A mixture of 1-(4-chlorobenzyl)-6-(ethylthio)-3-isopropyl-1,3,5-triazine-2,4(1H,3H)-dione (0.60 g, 1.78 mmol), 3-chloro-4-isopropoxyaniline (0.99 g, 5.3 mmol) and acetic acid (10 mL) was heated at 90° C. for 6 hours. Then, the reaction mixture was poured into saturated sodium hybrogen carbonate solution (10 mL), and the resulting mixture was extracted with ethyl acetate (10 mL). The extract was washed with saturated sodium hybrogen carbonate solution (10 mL) and brine (10 mL), dried over anhydrous sodium sulphate, and then concentrated in vacuo. The resulting residue was purified on a silica gel column chromatography (ethyl acetate/hexane). The aimed compound was triturated with diethyl ether and hexane to give 6-(3-chloro-4-isopropoxyphenylamino)-1-(4-chlorobenzyl)-3-isopropyl-1,3,5-triazine-2,4(1H,3H)-dione (0.605 g, yield: 73%) as colorless solid.

Melting point: 167° C.

1H-NMR (δ ppm TMS/DMSO-d6): 1.28 (6H, d, J=6.0 Hz), 1.34 (6H, d, J=6.9 Hz), 4.62 (1H, m), 4.83 (1H, sept, J=6.9 Hz), 5.18 (2H, brs), 7.12-7.15 (2H, m), 7.34-7.37 (3H, m), 7.43 (2H, d, J=8.7 Hz), 9.23 (1H, brs).

Example 4 Preparation of 1-(4-chlorobenzyl)-6-(methylthio)-1,3,5-triazine-2,4(1H,3H)-dione

To a mixture of 1-(4-chlorobenzyl)thiourea (11.19 g, 55.8 mmol) and metanol (50 mL) was added methyl iodide (4.18 mL, 66.9 mmol) under ice-cooling, and the resulting mixture was stirred at room temperature for 5 hours. Then, the reaction mixture was concentrated in vacuo. To the resulting residue were added dichloromethane (60 mL) and N,N-diisopropylethylamine (29.2 mL, 167 mmol), and then a solution of N-(chlorocarbonyl) isocyanate (4.94 mL, 61.4 mmol) in dichloromethane (20 mL) was added to the resulting mixture under ice-cooling gradually. The resulting mixture was stirred at room temperature for 1 hour. Then, the precipitated solid was collected by filtration. The obtained solid was washed with a small amount of dichloromethane and dried under reduced pressure to give 1-(4-chlorobenzyl)-6-(methylthio)-1,3,5-triazine-2,4(1H,3H)-dione (9.19 g, yield: 58%) as colorless solid.

1H-NMR (δ ppm TMS/DMSO-d6): 2.46 (3H, s), 5.04 (2H, s), 7.31-7.43 (4H, m), 11.60 (1H, brs).

Example 5 Preparation of 1-(4-chlorobenzyl)-6-(3-fluoro-4-isopropoxyphenylamino)-1,3,5-triazine-2,4(1H,3H)-dione

A mixture of 1-(4-chlorobenzyl)-6-(methylthio)-1,3,5-triazine-2,4(1H,3H)-dione (4.21 g, 14.8 mmol), 3-fluoro-4-isopropoxyaniline (3.77 g, 22.3 mmol), t-butanol (84 mL) and acetic acid (17 mL) was heated at reflux for 8 hours. Then, the reaction mixture was poured into saturated sodium hybrogen carbonate solution (30 mL), and the resulting mixture was extracted with ethyl acetate (10 mL). The extract was washed with saturated sodium hybrogen carbonate solution (10 mL) and brine (10 mL), dried over anhydrous sodium sulphate, and then concentrated in vacuo. The resulting residue was purified on a silica gel column chromatography (ethyl acetate/hexane). The aimed compound was triturated with diisopropyl ether to give 1-(4-chlorobenzyl)-6-(3-fluoro-4-isopropoxyphenylamino)-1,3,5-triazine-2,4(1H,3H)-dione (4.54 g, yield: 76%) as colorless solid.

1H-NMR (δ ppm TMS/CDCl₃): 1.36 (6H, d, J=6.1 Hz), 4.49 (1H, sept, J=6.1 Hz), 5.14 (2H, s), 6.47 (1H, m), 6.59 (1H, m), 6.97 (1H, m), 7.30 (2H, d, J=8.5 Hz), 7.47 (2H, d, J=8.5 Hz), 8.06 (1H, brs).

Example 6 Preparation of 1-(4-chlorobenzyl)-6-(3-fluoro-4-isopropoxyphenylamino)-3-(2-pyridylmethyl)-1,3,5-triazine-2,4(1H,3H)-dione

To a mixture of 1-(4-chlorobenzyl)-6-(3-fluoro-4-isopropoxyphenylamino)-1,3,5-triazine-2,4(1H,3H)-dione (0.15 g, 0.37 mmol) and DMF (3 mL) was added potassium t-butoxide (09 mg, 0.82 mmol), and the resulting mixture was stirred at room temperature for 5 minutes. To the mixture was added 2-(bromomethyl)pyridine hydrobromide (0.103 g, 0.41 mmol), and the resulting mixture was stirred at 60° C. for 2 hours. Then, water (20 mL) was poured into the mixture, and the resulting mixture was extracted with ethyl acetate (20 mL×2). The extract was washed with brine (20 mL), dried over anhydrous sodium sulphate, and then concentrated in vacuo. The resulting residue was purified on a silica gel column chromatography (ethyl acetate/hexane). The aimed compound was triturated with hexane to give 1-(4-chlorobenzyl)-6-(3-fluoro-4-isopropoxyphenylamino)-3-(2-pyridylmethyl)-1,3,5-triazine-2,4(1H,3H)-dione (069 g, yield: 37%) as colorless solid.

1H-NMR (δ ppm TMS/CDCl₃): 1.36 (2H, d, J=6.2 Hz), 4.47 (1H, sept, J=6.2 Hz), 5.15 (2H, s), 5.19 (2H, s), 6.51 (1H, m), 6.62 (1H, m), 6.97 (1H, m), 7.17-7.48 (7H, m), 7.65 (1H, m), 8.53 (1H, m).

Example 7 Preparation of 1-(4-chlorobenzyl)-6-(3-fluoro-4-isopropoxyphenylamino)-3-(2-hydroxyethyl)-1,3,5-triazine-2,4(1H,3H)-dione

To a mixture of 1-(4-chlorobenzyl)-6-(methylthio)-1,3,5-triazine-2,4(1H,3H)-dione (0.28 g, 1 mmol), 2-(tetrahydro-2H-pyran-2-yloxy)enthanol (0.15 g, 1.00 mmol), triphenylphosphine (0.53 g, 2 mmol) and THF (5 mL) was gradually added diisopropylazocarboxylate (0.23 mL, 1.2 mmol) dropwise under ice-cooling, and the resulting mixture was stirred at room temperature for 3 hours. The mixture was poured into water (20 mL), and the resulting mixture was extracted with ethyl acetate (20 mL×2). The extract was washed with brine (20 mL), dried over anhydrous sodium sulphate, and then concentrated in vacuo. The resulting residue was purified on a silica gel column chromatography (ethyl acetate/hexane) to give 1-(4-chlorobenzyl)-6-(methylthio)-3-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]-1,3,5-triazine-2,4(1H,3H)-dione (0.32 g, yield: 78%) as colorless amorphous.

1H-NMR (δ ppm TMS/CDCl₃): 1.42-1.83 (6H, m), 2.58 (3H, s), 3.47 (1H, m), 3.74-4.32 (5H, m), 4.63 (1H, m), 5.10 (2H, s), 7.28-7.33 (4H, m).

A mixture of 1-(4-chlorobenzyl)-6-(methylthio)-3-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]-1,3,5-triazine-2,4(1H,3H)-dione (0.32 g, 0.78 mmol), 3-fluoro-4-isopropoxyaniline (0.40 g, 2.4 mmol) and acetic acid (3 mL) was heated at 10° C. for 3 hours. Then, the reaction mixture was poured into saturated sodium hybrogen carbonate solution (10 mL), and the resulting mixture was extracted with chloroform (10 mL×2). The extract was dried over anhydrous sodium sulphate, and then concentrated in vacuo. The resulting residue was purified on a silica gel column chromatography (methanol/chloroform). The aimed compound was triturated with diisopropyl ether and hexane to give 1-(4-chlorobenzyl)-6-(3-fluoro-4-isopropoxyphenylamino)-3-(2-hydroxyethyl)-1,3,5-triazine-2,4(1H,3H)-dione (0.12 g, yield: 33%) as colorless solid.

Example 8 Preparation of 3-(2-aminoethyl)-1-(4-chlorobenzyl)-6-(3-fluoro-4-isopropoxyphenylamino)-1,3,5-triazine-2,4(1H,3H)-dione hydrochloride

To 3-(2-t-butoxycarbonylaminoethyl)-1-(4-chlorobenzyl)-6-(3-fluoro-4-isopropoxyphenylamino)-1,3,5-triazine-2,4(1H,3H)-dione (0.44 g, 0.8 mmol) was added 4 mol/L solution of hydrochloric acid in dioxane (5 mL) under ice-cooling, and the resulting mixture was stirred at room temperature for 1 hour. Then, the precipitated solid was collected by filtration. The resulting solid was washed with diethyl ether, dried under reduced pressure to give 3-(2-aminoethyl)-1-(4-chlorobenzyl)-6-(3-fluoro-4-isopropoxyphenylamino)-1,3,5-triazine-2,4(1H,3H)-dione hydrochloride (0.31 g, yield: 81%) as colorless solid.

1H-NMR (δ ppm TMS/DMSO-d6): 1.27 (6H, d, J=5.9 Hz), 3.01 (2H, m), 3.98 (2H, m), 4.57 (1H, sept, J=5.9 Hz), 5.27 (2H, brs), 6.98-7.17 (3H, m), 7.42 (3H, s), 7.87 (2H, brs).

Example 9 Preparation of 3-(2-acetylaminoethyl)-1-(4-chlorobenzyl)-6-(3-fluoro-4-isopropoxyphenylamino)-1,3,5-triazine-2,4(1H,3H)-dione

To a mixture of 3-(2-aminoethyl)-1-(4-chlorobenzyl)-6-(3-fluoro-4-isopropoxyphenylamino)-1,3,5-triazine-2,4(1H,3H)-dione hybrochloride (0.104 g, 0.22 mmol), triethylamine (074 mL, 0.54 mmol), dimethylaminopyridine (026 g, 0.22 mmol) and THF (2 mL) was added acetyl chloride (023 mL, 0.32 mmol) dropwise under ice-cooling, and the resulting mixture was stirred at room temperature for 30 minutes. Water (20 mL) was poured into the reaction mixture, and the resulting mixture was extracted with ethyl acetate (10 mL×2). The extract was washed with brine (10 mL), dried over anhydrous sodium sulphate, and then concentrated in vacuo. The resulting residue was purified on a silica gel column chromatography (ethyl acetate/hexane). The aimed compound was triturated with diisopropyl ether and hexane to give 3-(2-acetylaminoethyl)-1-(4-chlorobenzyl)-6-(3-fluoro-4-isopropoxyphenylamino)-1,3,5-triazine-2,4(1H,3H)-dione (0.104 g, yield: 99%) as colorless solid.

1H-NMR (δ ppm TMS/CDCl₃): 1.37 (6H, d, J=6.1 Hz), 1.86 (3H, s), 3.51 (2H, m), 4.0 (2H, m), 4.47 (1H, sept, J=6.1 Hz), 5.16 (2H, s), 5.83 (1H, m), 6.51 (1H, m), 6.60 (1H, m), 6.97 (1H, m), 7.27-7.51 (5H, m).

Example 10 Preparation of 1-(4-chlorobenzyl)-6-(3-fluoro-4-isopropoxyphenylamino)-3-(mothoxycarbonylmethyl)-1,3,5-triazine-2,4(1H,3H)-dione

To a mixture of 1-(4-chlorobenzyl)-6-(methylthio)-1,3,5-triazine-2,4(1H,3H)-dione (0.28 g, 1 mmol) and THF (3 mL) was added DBU (0.166 mL, 1.1 mmol), and the resulting mixture was stirred at room temperature for 5 minutes. Bromomethyl acetate (0.104 mL, 1.1 mmol) was added to the mixture, and the resulting mixture was stirred at room temperature for 3 hours. Water (20 mL) was poured into the mixture, and the precipitated solid was collected by filtration. The resulting solid was dried and purified on a silica gel column chromatography (ethyl acetate/hexane) to give 1-(4-chlorobenzyl)-3-(mothoxycarbonylmethyl)-6-(methylthio)-1,3,5-triazine-2,4(1H,3H)-dione (0.25 g, yield: 69%) as colorless solid.

1H-NMR (δ ppm TMS/CDCl₃): 2.59 (3H, s), 3.78 (3H, s), 4.69 (2H, s), 5.13 (2H, s), 7.27-7.35 (4H, m).

A mixture of 1-(4-chlorobenzyl)-3-(mothoxycarbonylmethyl)-6-(methylthio)-1,3,5-triazine-2,4(1H,3H)-dione (0.24 g, 0.68 mmol), 3-fluoro-4-isopropoxyaniline (0.17 mg, 1.03 mmol), t-butanol (4.8 mL) and acetic acid (0.4 mL) was heated at reflux for 32 hours. Then, the mixture was poured into saturated sodium hybrogen carbonate solution (20 mL), and the resulting mixture was extracted with ethyl acetate (10 mL). The extract was washed with brine (10 mL), dried over anhydrous sodium sulphate, and concentrated in vacuo. The resulting residue was purified on a silica gel column chromatography (ethyl acetate/hexane). The resulting aimed compound was triturated with diisopropyl ether to give 1-(4-chlorobenzyl)-6-(3-fluoro-4-isopropoxyphenylamino)-3-(mothoxycarbonylmethyl)-1,3,5-triazine-2,4(1H,3H)-dione (0.31 g, yield: 95%) as colorless amorphous.

1H-NMR (δ ppm TMS/CDCl₃): 1.37 (6H, d, J=5.9 Hz), 3.78 (3H, s), 4.47 (1H, sept, J=5.9 Hz), 4.58 (2H, s), 5.17 (2H, s), 6.50 (1H, m), 6.60 (1H, m), 6.97 (1H, m), 7.28-7.47 (5H, m).

Example 11 Preparation of 1-(4-chlorobenzyl)-6-(3-fluoro-4-isopropoxyphenylamino)-3-(hydroxycarbonylmethyl)-1,3,5-triazine-2,4(1H,3H)-dione

To a mixture of 1-(4-chlorobenzyl)-6-(3-fluoro-4-isopropoxyphenylamino)-3-(methoxycarbonylmethyl)-1,3,5-triazine-2,4(1H,3H)-dione (0.30 g, 0.63 mmol), methanol (3 mL) and THF (3 mL) was added 1 mol/L lithium hydroxide (3.8 mL) under ice-cooling, and the resulting mixture was stirred at room temperature for 1 hour. Then, the mixture was treated with 2 mol/L hydrochloric acid to pH2 or less. The mixture was poured into brine (20 mL), and the resulting mixture was extracted with chloroform (10 mL×3). The extract was dried over anhydrous sodium sulphate and concentrated in vacuo. The resulting residue was triturated with diethyl ether and hexane to give 1-(4-chlorobenzyl)-6-(3-fluoro-4-isopropoxyphenylamino)-3-(hydroxycarbonylmethyl)-1,3,5-triazine-2,4(1H,3H)-dione (0.28 g, yield: 97%) as colorless solid.

1H-NMR (δ ppm TMS/CDCl₃): 1.36 (6H, d, J=6.1 Hz), 4.47 (1H, sept, J=6.1 Hz), 4.62 (2H, s), 5.18 (2H, s), 6.51 (1H, m), 6.60 (1H, m), 6.96 (1H, m), 7.30 (2H, d, J=8.7 Hz), 7.45 (2H, d, J=8.7 Hz), 7.64 (1H, brs).

Example 12 Preparation of 1-(4-chlorobenzyl)-6-(3-fluoro-4-isopropoxyphenylamino)-3-(methylcarbamoylmethyl)-1,3,5-triazine-2,4(1H,3H)-dione

To a mixture of 1-(4-chlorobenzyl)-6-(3-fluoro-4-isopropoxyphenylamino)-3-(hydroxycarbonylmethyl)-1,3,5-triazine-2,4(1H,3H)-dione (083 g, 0.19 mmol) and DMF (2 mL) were added methylamine hydrochloride (015 g, 0.21 mmol), 1-hydroxybenzotriazole hydrate (03 g, 0.2 mmol), 4-dimethylaminopyridine (002 g, 02 mmol), 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (038 g, 0.2 mmol) and triethylamine (03 mL, 0.21 mmol), and the resulting mixture was stirred at 60° C. for 4 hours. Then, the mixture was poured into water (20 mL), and the resulting mixture was extracted with ethyl acetate (20 mL). The extract was washed with brine (10 mL), dried over anhydrous sodium sulphate and concentrated in vacuo. The resulting residue was purified on a silica gel column chromatography (ethyl acetate/hexane) and the aimed compound was triturated with diisopropyl ether to give 1-(4-chlorobenzyl)-6-(3-fluoro-4-isopropoxyphenylamino)-3-(methylcarbamoylmethyl)-1,3,5-triazine-2,4(1H,3H)-dione (076 g, yield: 89%) as colorless solid.

1H-NMR (δ ppm TMS/CDCl₃): 1.37 (6H, d, J=6.1 Hz), 2.85 (3H, d, J=4.9 Hz), 4.37 (2H, s), 4.46 (1H, sept, J=6.1 Hz), 5.15 (2H, s), 5.78 (1H, d, J=4.7 Hz), 6.46 (1H, m), 6.57 (1H, m), 6.95 (1H, m), 7.27-7.46 (4H, m), 7.99 (1H, ms).

Example 13 Preparation of 4-chloro-1-(4-chlorobenzyl)-6-(3-fluoro-4-isopropoxyphenylamino)-1,3,5-triazine-2(1H)-one

To 1-(4-chlorobenzyl)-6-(3-fluoro-4-isopropoxyphenylamino)-1,3,5-triazine-2,4(1H,3H)-dione (0.486 g, 1.2 mmol) was added phosphorous oxychloride (2.24 mL, 24 mmol), and the resulting mixture was stirred at 50° C. for 2 hours. Then, the mixture was concentrated in vacuo. The resulting residue was dissolved in ethyl acetate (30 mL), washed with saturated sodium hybrogen carbonate solution (10 mL) and brine (10 mL), dried over anhydrous sodium sulphate and concentrated in vacuo to give crude 4-chloro-1-(4-chlorobenzyl)-6-(3-fluoro-4-isopropoxyphenylamino)-1,3,5-triazine-2(1H)-one (0.57 g) as colorless solid.

1H-NMR (δ ppm TMS/CDCl₃): 1.35 (6H, d, J=6.3 Hz), 4.51 (1H, sept, J=6.3 Hz), 5.28 (2H, s), 6.72 (1H, brs), 6.80 (1H, m), 6.91 (1H, m), 7.08 (1H, m), 7.30 (2H, d, J=8.4 Hz), 7.44 (2H, d, J=8.4 Hz).

Example 14 Preparation of 1-(4-chlorobenzyl)-6-(3-fluoro-4-isopropoxyphenylamino)-4-(2-hydroxyethoxy)-1,3,5-triazine-2(1H)-one

To a mixture of 2-(tetrahydro-2H-pyrane-2-yloxy)enthanol (0.17 mL, about 1.25 mmol) and THF (5.6 mL) was added 60% sodium hydride (05 g, 1.25 mmol), and the resulting mixture was stirred at room temperature for 10 minutes. A solution of crude 4-chloro-1-(4-chlorobenzyl)-6-(3-fluoro-4-isopropoxyphenylamino)-1,3,5-triazine-2(1H)-one (0.224 g, about 0.5 mmol) in THF (5.6 mL) was added to the mixture under ice-cooling, and the resulting mixture was stirred at room temperature for 5 hours. Then, half-saturated ammonium chloride aqueous solution (50 mL) was poured into the mixture and the resulting mixture was extracted with ethyl acetate (50 mL). The extract was washed with brine (10 mL), dried over anhydrous sodium sulphate, and concentrated in vacuo. The resulting residue was purified on a silica gel column chromatography (ethyl acetate/hexane) and the aimed compound was triturated with hexane to give 1-(4-chlorobenzyl)-6-(3-fluoro-4-isopropoxyphenylamino)-4-[2-(tetrahydro-2H-pyrane-2-yloxy)ethoxy]-1,3,5-triazine-2(1H)-one (0.166 g, yield: 62%) as colorless oil.

To a mixture of 1-(4-chlorobenzyl)-6-(3-fluoro-4-isopropoxyphenylamino)-4-[2-(tetrahydro-2H-pyrane-2-yloxy)ethoxy]-1,3,5-triazine-2(1H)-one (0.15 g, 0.28 mmol) and methanol (1.5 mL) was added p-toluenesulfonic acid hydrate (08 g, 0.4 mmol), and the resulting mixture was stirred at room temperature for 2 hours. Then, the mixture was poured into half-saturated sodium hybrogen carbonate solution (10 mL) and the resulting mixture was extracted with ethyl acetate (20 mL). The extract was washed with brine (10 mL), dried over anhydrous sodium sulphate, and concentrated in vacuo. The resulting residue was purified on a silica gel column chromatography (methanol/chloroform) and the aimed compound was triturated with hexane to give 1-(4-chlorobenzyl)-6-(3-fluoro-4-isopropoxyphenylamino)-4-(2-hydroxyethoxy)-1,3,5-triazine-2(1H)-one (0.104 g, yield: 83%) as colorless solid.

1H-NMR (δ ppm TMS/CDCl₃): 1.34 (6H, d, J=6.1 Hz), 2.53 (1H, brs), 3.91 (2H, brs), 4.44-4.52 (3H, m), 5.30 (2H, s), 6.60 (1H, brs), 6.75-7.10 (3H, m), 7.27-7.43 (4H, m).

Example 15 Preparation of 4-benzylamino-1-(4-chlorobenzyl)-6-(3-fluoro-4-isopropoxyphenylamino)-1,3,5-triazine-2(1H)-one

To a mixture of crude 4-chloro-1-(4-chlorobenzyl)-6-(3-fluoro-4-isopropoxyphenylamino)-1,3,5-triazine-2(1H)-one (0.19 g, about 0.4 mmol) and THF (4.7 mL) was added benzylamine (0.108 mL, 1 mmol), and the resulting mixture was stirred at room temperature for 6 hours. Water (10 mL) and ethyl acetate (10 mL) were poured into the mixture and the precipitated solid was collected by filtration. The obtained solid was washed with ethyl acetate, dried under reduced pressure to give 4-benzylamino-1-(4-chlorobenzyl)-6-(3-fluoro-4-isopropoxyphenylamino)-1,3,5-triazine-2(1H)-one (0.102 g, yield: 52%) as colorless solid.

1H-NMR (δ ppm TMS/DMSO-d6): 1.25 (6H, d, J=5.7 Hz), 4.28 (1H, m), 4.41 (1H, m), 4.54 (1H, sept, J=5.7 Hz), 5.22 (2H, m), 7.08-7.52 (8H, m), 7.90 (1H, brs), 8.94 (1H, brs).

Example 16 Preparation of 1-(4-chlorobenzyl)-4-(dodecylthio)-6-(3-fluoro-4-isopropoxyphenylamino)-1,3,5-triazine-2(1H)-one

To a mixture of 1-dodecanethiol (0.24 mL, 1.0 mmol) and THF (4.8 mL) was added 60% sodium hydride (045 g, 1.0 mmol), and the resulting mixture was stirred at room temperature for 10 minutes. A solution of crude 4-chloro-1-(4-chlorobenzyl)-6-(3-fluoro-4-isopropoxyphenylamino)-1,3,5-triazine-2(1H)-one (0.19 g, about 0.4 mmol) in THF (2 mL) was added to the reaction mixture under ice-cooling. After the reaction mixture was stirred at 50° C. for 5 hours, half-saturated ammonium chloride aqueous solution (50 mL) was poured into the mixture and the resulting mixture was extracted with ethyl acetate (50 mL). The extract was washed with brine (10 mL), dried over anhydrous sodium sulphate, and concentrated in vacuo. The resulting residue was purified on a silica gel column chromatography (ethyl acetate/hexane) and the aimed compound was triturated with hexane to give 1-(4-chlorobenzyl)-4-(dodecylthio)-6-(3-fluoro-4-isopropoxyphenylamino)-1,3,5-triazine-2(1H)-one (092 g, yield: 39%) as colorless oil.

1H-NMR (δ ppm TMS/CDCl₃): 0.89 (3H, t, J=6.9 Hz), 1.27 (14H, s), 1.34 (6H, d, J=6 Hz), 1.50-1.70 (6H, m), 3.02 (2H, t, J=7.5 Hz), 4.48 (1H, sept, J=6 Hz), 5.26 (2H, s), 6.52 (1H, brs), 6.75 (1H, m), 6.88 (1H, m), 7.10 (1H, m), 7.28-7.50 (4H, m).

Example 17 Preparation of 1-(4-chlorobenzyl)-6-(4-hydroxycarbonylphenylamino)-3-isopropyl-1,3, 5-triazine-2,4(1H,3H)-dione

To a mixture of 1-(4-chlorobenzyl)-6-(4-methoxycarbonylphenylamino)-3-isopropyl-1,3,5-triazine-2,4(1H,3h)-dione (0.70 g, 1.63 mmol), methanol (4 mL) and THF (4 mL) was added 2 mol/L lithium hydroxide (4.9 mL) under ice-cooling, and the resulting mixture was stirred at room temperature for 8 hours. The mixture was poured into water (50 mL) and the resulting mixture was treated with 2 mol/L hydrochloric acid to pH3 or less. The resulting mixture was extracted with ethyl acetate (50 mL×2). The extract was washed with brine (50 mL), dried over anhydrous sodium sulphate and concentrated in vacuo. The obtained solid was washed with diethyl ether to give 1-(4-chlorobenzyl)-6-(4-hydroxycarbonylphenylamino)-3-isopropyl-1,3,5-triazine-2,4(1H,3H)-dione (0.60 g, yield: 89%) as colorless solid.

1H-NMR (δ ppm TMS/CDCl₃): 1.46 (6H, d, J=6.9 Hz), 4.98 (1H, sept, J=6.9 Hz), 5.19 (2H, s), 6.90 (2H, d, J=8.1 Hz), 7.31 (2H, d, J=8.7 Hz), 7.50 (2H, d, J=8.7 Hz), 7.90 (2H, d, J=8.1 Hz).

Example 18 Preparation of 1-(4-chlorobenzyl)-6-[4-(N-benzylcarbamoyl)phenylamino]-3-isopropyl-1,3, 5-triazine-2,4(1H,3H)-dione

To a mixture of 1-(4-chlorobenzyl)-6-(4-hydroxycarbonylphenylamino)-3-isopropyl-1,3,5-triazine-2,4(1H,3h)-dione (08 g, 0.19 mmol) and THF (2 mL) were added benzylamine (023 mL, 0.21 mmol), 1-hydroxybenzotriazole (03 g, 0.21 mmol), 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (041 g, 0.2 mmol) and triethylamine (03 mL, 0.21 mmol) under ice-cooling, and the resulting mixture was stirred at room temperature for 4 hours. The mixture was poured into water (30 mL) and the resulting mixture was extracted with ethyl acetate (30 mL). The extract was washed with brine (30 mL), dried over anhydrous sodium sulphate and concentrated in vacuo. The resulting residue was purified on a silica gel column chromatography (ethyl acetate/hexane) and the aimed compound was triturated with diethyl ether to give 1-(4-chlorobenzyl)-6-[4-(N-benzylcarbamoyl)phenylamino]-3-isopropyl-1,3,5-triazine-2,4(1H,3H)-dione (07 g, yield: 72%) as colorless solid.

1H-NMR (δ ppm TMS/CDCl₃): 1.43 (6H, d, J=6.9 Hz), 4.67 (2H, d, J=4.0 Hz), 4.96 (1H, sept, J=6.9 Hz), 5.18 (2H, s), 6.34 (1H, m), 6.88 (2H, d, J=8.4 Hz), 7.17 (1H, brs), 7.29-7.34 (6H, m), 7.50 (2H, d, J=8.4 Hz), 7.80 (2H, d, J=8.4 Hz).

Example 19 Preparation of 1-(4-chlorobenzyl)-6-(3-chloro-4-isopropoxyphenylamino)-4-hydroxycarbonylethyl-1,3,5-triazine-2(1H)-one

A mixture of 4-chloro-1-(4-chlorobenzyl)-6-(3-fluoro-4-isopropoxyphenylamino)-1,3,5-triazine-2(1H)-one (0.15 g, 0.34 mmol), 1,1′-bis(di-t-butylphosphinoferrocene)palladium(II) dichloride (22.23 mg, 034 mmol), and THF (3 mL) was placed in a flask under nitrogen. To the mixture were added (E)-ethyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolane-2-yl)acrylate (063 g, 0.49 mmol) and 2 mol/L potassium carbonate (0.682 mL, 1.364 mmol), and the resulting mixture was heated at reflux for 7 hours. Then, the mixture was poured into water (30 mL) and the resulting mixture was extracted with chloroform (30 mL). The extract was dried over anhydrous sodium sulphate and concentrated in vacuo. The resulting residue was purified on a height performance liquid chromatography (0.3% HCO2H H2O/MeCN 50-80%) to give 1-(4-chlorobenzyl)-6-(3-chloro-4-isopropoxyphenylamino)-ethoxycarbonylethenyl-1,3,5-triazine-2(1H)-one (05 g, yield: 30%) as pale orange oil.

1H-NMR (δ ppm TMS/DMSO-d6): 1.20-1.28 (9H, m), 4.17-4.22 (2H, m), 4.54 (1H, brs), 5.10 (2H, brs), 7.40 (8H, brs), 8.14 (1H, s), 9.77 (1H, s).

To a mixture of 1-(4-chlorobenzyl)-6-(3-chloro-4-isopropoxyphenylamino)-ethoxycarbonylethenyl-1,3,5-triazine-2(1H)-one (05 g, 0.1 mmol), THF (1 mL), EtOH (1 mL) and water (0.3 mL) was added lithium hydroxide hydrate (12.5 mg, 0.3 mmol), and the resulting mixture was stirred at room temperature for 3 days. The reaction mixture was purified on a height performance liquid chromatography (0.3% HCO2H H2O/MeCN 40-70%) to give 1-(4-chlorobenzyl)-6-(3-chloro-4-isopropoxyphenylamino)-4-hydroxycarbonylethenyl-1,3,5-triazine-2(1H)-one (27 mg, yield: 57%) as pale orange oil.

The obtained intermediate was dissolved in methanol (3 mL), the resulting solution was conducted a catalytic reduction by using H-Cube (10% Pt-C, H2=1 atm). The reaction mixture was purified on a height performance liquid chromatography (0.3% HCO2H H2O/MeCN 50-80%) to give 1-(4-chlorobenzyl)-6-(3-chloro-4-isopropoxyphenylamino)-4-hydroxycarbonylethyl-1,3,5-triazine-2(1H)-one (2.3 mg, yield: 8.5%) as colorless oil.

1H-NMR (δ ppm TMS/CDCl₃): 1.36 (6H, d, J=5.7 Hz), 2.22 (1H, t, J=7.8 Hz), 2.74 (3H, brs), 4.48 (1H, sept, J=5.7 Hz), 5.18 (2H, s), 6.88 (2H, s), 7.13 (1H, s), 7.30 (2H, d, J=8.4 Hz), 7.45 (2H, d, J=8.4 Hz).

Example 20 Preparation of (R)-1-(4-chlorobenzyl)-6-(3-fluoro-4-isopropoxyphenylamino)-3-(2-methoxycarbonylpropyl)-1,3,5-triazine-2,4(1H,3H)-dione

To a mixture of 1-(4-chlorobenzyl)-6-(ethylthio)-1,3,5-triazine-2,4(1H,3H)-dione (1.0 g, 3.4 mmol), di-2-methoxyethyl azocarboxylate (1.02 g, 4.4 mmol), triphenylphosphine (1.15 g, 4.4 mmol) and dioxane (8 mL) was gradually added methyl (R)-(−)-3-hybroxyisobutyrate (0.52 g, 4.4 mmol), and the resulting mixture was stirred at room temperature for 1 hour. Water (20 mL) was poured into the mixture, and the resulting mixture was extracted with ethyl acetate (20 mL×2). The extract was washed with brine (20 mL), dried over anhydrous magnesium sulfate, and then concentrated in vacuo. The resulting residue was purified on a silica gel column chromatography (ethyl acetate/hexane) to give (R)-1-(4-chlorobenzyl)-6-(ethylthio)-3-(2-methoxycarbonylpropyl)-1,3,5-triazine-2,4(1H,3H)-dione (0.98 g, yield: 74%) as colorless amorphous.

1H-NMR (δ ppm TMS/CDCl₃): 1.19 (3H, d, J=5.7 Hz), 1.37 (3H, t, J=7.1 Hz), 2.96 (1H, m), 3.12 (2H, q, J=7.1 Hz), 3.60 (3H, s), 3.98 (1H, m), 4.21 (1H, m), 5.08 (2H, s), 7.29-7.34 (4H, m).

A mixture of (R)-1-(4-chlorobenzyl)-6-(ethylthio)-3-(2-methoxycarbonylpropyl)-1,3,5-triazine-2,4(1H,3H)-dione (0.32 g, 0.8 mmol), 3-fluoro-4-isopropoxyaniline (0.20 g, 1.2 mmol), acetic acid (0.72 g, 12 mmol) and t-butanol (6 mL) was heated at reflux over night. Then, the mixture was poured into saturated sodium hybrogen carbonate solution (40 mL), and the resulting mixture was extracted with ethyl acetate (40 mL×2). The extract was washed with 2 mol/L hydrochloric acid (20 mL×2), dried over anhydrous sodium sulphate, and then concentrated in vacuo. The resulting residue was purified on a silica gel column chromatography (ethyl acetate/hexane). The obtained compound was triturated with diethyl ether to give (R)-1-(4-chlorobenzyl)-6-(3-fluoro-4-isopropoxyphenylamino)-3-(2-methoxycarbonylpropyl)-1,3,5-triazine-2,4(1H,3H)-dione (0.29 g, yield: 71%) as lilac powder.

Example 21 Preparation of (R)-1-(4-chlorobenzyl)-6-(3-fluoro-4-isopropoxyphenylamino)-3-(2-hydroxycarbonylpropyl)-1,3,5-triazine-2,4(1H,3H)-dione

To a mixture of (R)-1-(4-chlorobenzyl)-6-(3-fluoro-4-isopropoxyphenylamino)-3-(2-methoxycarbonylisopropyl)-1,3,5-triazine-2,4(1H,3H)-dione (0.26 g, 0.5 mmol) and dioxane (4 mL) was added 1 mol/L lithium hydroxide (1.6 mL), and the resulting mixture was stirred at 50° C. for 6 hours. Then, water (50 mL) was poured into the mixture. The resulting mixture was treated with 2 mol/L hydrochloric acid to about pH3. The precipitated solid was collected by filtration and the obtained solid was dried under reduced pressure at 40° C. for 2 hours to give (R)-1-(4-chlorobenzyl)-6-(3-fluoro-4-isopropoxyphenylamino)-3-(2-hydroxycarbonylpropyl)-1,3,5-triazine-2,4(1H,3H)-dione (0.21 g, yield: 84%) as colorless solid.

1H-NMR (δ ppm TMS/CDCl₃): 1.19 (3H, d, J=5.7 Hz), 1.34 (6H, d, J=5.7 Hz), 2.91 (1H, m), 3.89 (1H, m), 4.11 (1H, m), 4.44 (1H, sept, J=5.7 Hz), 5.16 (2H, s), 6.47-6.60 (2H, m), 6.93 (1H, m), 7.28-7.44 (4H, m), 7.94 (1H, brs).

Example 22 Preparation of 1-(4-chlorobenzyl)-6-(3-fluoro-4-isopropoxyphenylamino)-3-[2,2-di(hydroxymethyl)propyl]-1,3,5-triazine-2,4(1H,3H)-dione

To a mixture of 1-(4-chlorobenzyl)-6-(3-fluoro-4-isopropoxyphenylamino)-3-(2,2,5-trimethyl-1,3-dioxane-5-yl)methyl-1,3,5-triazine-2,4(1H,3H)-dione (7.9 g, 14.44 mmol) and methanol (160 mL) was added p-toluenesulfonic acid monohydrate (5.49 g, 28.9 mmol), and the resulting mixture was stirred at room temperature for 1 hour. Then, the mixture was poured into saturated sodium hybrogen carbonate solution (20 mL) and the resulting mixture was extracted with ethyl acetate (30 mL×2). The extract was washed with brine (30 mL), dried over anhydrous sodium sulphate, and concentrated in vacuo. The resulting residue was purified on a silica gel column chromatography (ethyl acetate/hexane). The obtained compound was triturated with water. The precipitated solid was collected by filtration and the obtained solid was dried under reduced pressure at 70° C. for 6 hours to give 1-(4-chlorobenzyl)-6-(3-fluoro-4-isopropoxyphenylamino)-3-[2,2-di(hydroxymethyl)propyl]-1,3,5-triazine-2,4(1H,3H)-dione (5.12 g, yield: 70%) as white powder.

1H-NMR (δ ppm TMS/CDCl₃): 1.37 (6H, d, J=6.0 Hz), 3.26-3.46 (6H, m), 3.99 (2H, s), 4.48 (1H, sept, J=6.0 Hz), 5.19 (2H, s), 6.49-6.64 (2H, m), 6.99 (1H, m), 7.30-7.51 (5H, m).

Elemental Analysis

Calculated value C24H28ClFN4O5.⅓H2O,

-   -   C, 56.19; H, 5.63; Cl, 6.91; F, 3.70; N, 10.92     -   Water: 1.18%

Measured value C: 56.33, H: 5.60, Cl: 6.79, F: 3.58, N: 11.06

-   -   Karl Fischer moisture measurement: 1.02%

The following compounds were synthesized in a manner similar to those described in the general procedures and Examples. The chemical structure of the compounds and the physical properties of them are described below.

(Method of Identification for the Compound)

LC/MS data of the compounds were measured under any one of the following 3 conditions (Method A, B and C), and a retention time and [M+H]⁺ are shown.

(Method 1)

Column:Luna C18(2) (5 μm, i.d. 4.6×50 mm) (Phenomenex)

Flow rate: 3 mL/min

UV detection wavelength: 254 nm

Mobile phase: [A] is 0.1% formic acid-containing aqueous solution, and [B] is 0.1% formic acid-containing acetonitrile solution

Gradient: Linear gradient of 10% to 10% solvent [B] for 3 minutes was performed, and 10% solvent [B] was maintained for 1 minute.

(Method 2)

Column: Xbridge C18 (5 μm, i.d. 4.6×50 mm) (Waters)

Flow rate: 3 mL/min

UV detection wavelength: 254 nm

Mobile phase: [A] is 0.1% formic acid-containing aqueous solution, and [B] is 0.1% formic acid-containing acetonitrile solution

Gradient: Linear gradient of 10% to 10% solvent [B] for 3 minutes was performed, and 10% solvent [B] was maintained for 1 minute.

(Method 3)

Column: Shim-pack XR-ODS (2.2 μm, i.d. 50×3.0 mm) (Shimadzu)

Flow rate: 1.6 mL/min

UV detection wavelength: 254 nm

Mobile phase: [A] is 0.1% formic acid-containing aqueous solution, and [B] is 0.1% formic acid-containing acetonitrile solution

Gradient: Linear gradient of 10% to 10% solvent [B] for 3 minutes was performed, and 10% solvent [B] was maintained for 1 minute.

(Method 4)

Column: Develosil RPAq, (50×4.5 mm)

Flow rate: 1.5 mL/min

UV detection wavelength: 254 nm

Mobile phase: [A] is 0.1% formic acid-containing aqueous solution, and [B] is 0.1% formic acid-containing acetonitrile solution

Gradient: 60% solvent [B] was maintained for 0.5 minute, linear gradient of 60% to 10% solvent [B] for 4.5 minutes was performed, and 10% solvent [B] was maintained for 1.0 minute.

TABLE 4 Compound Retention Chemical Structure No. [M + H] time (min) Method

1-001 469 2.46 3

1-002 493 2.49 3

1-003 399 2.31 3

1-004 473 2.47 3

1-005 461 2.37 3

TABLE 5 Compound Retention Chemical Structure No. [M + H] time (min) Method

1-006 457 2.48 3

1007 415 2.34 3

1-008 475 2.22 3

1-009 423 2.23 3

1-010 457 2.48 3

TABLE 6 Compound Retention Chemical Structure No. [M + H] time (min) Method

1-011 433 2.47 3

1-012 478 2.51 3

1-013 383 2.23 3

1-014 483 2.65 3

1-015 428 229 3

TABLE 7 Compound Retention Chemical Structure No. [M + H] time (min) Method

1-016 445 2.29 3

1-017 433 2.45 3

1-018 494 2.09 3

1-019 405 2.16 4

1-020 439 3.88 4

TABLE 8 Compound Retention Chemical Structure No. [M + H] time (min) Method

1-021 419 3.63 4

1-022 474 4.43 4

1-023 473 3.91 4

1-024 473 3.93 4

1-025 419 3.33 4

TABLE 9 Compound Retention Chemical Structure No. [M + H] time (min) Method

1-026 449 3.16 4

1-027 419 2.46 4

1-028 453 3.27 4

1-029 433 2.95 4

1-030 488 3.94 4

TABLE 10 Compound Retention Chemical Structure No. [M + H] time (min) Method

1-031 433 2.61 4

1-032 463 2.39 4

1-033 447 4.31 4

1-034 481 4.86 4

1-035 461 4.68 4

TABLE 11 Compound Retention Chemical Structure No. [M + H] time (min) Method

1-036 516 3.73 4

1-037 515 4.80 4

1-038 515 4.83 4

1-039 461 3.67 4

1-040 491 3.47 4

TABLE 12 Compound Retention Chemical Structure No. [M + H] time (min) Method

1-041 445 4.09 4

1-042 459 4.45 4

1-043 514 3.51 4

1-044 513 4.62 4

1-045 513 4.65 4

TABLE 13 Compound Retention Chemical Structure No. [M + H] time (min) Method

1-046 489 3.17 4

1-047 453 3.46 4

1-048 487 4.09 4

1-049 467 3.83 4

1-050 522 4.56 4

TABLE 14 Compound Retention Chemical Structure No. [M + H] time (min) Method

1-051 521 4.09 4

1-052 521 4.12 4

1-053 467 3.57 4

1-054 497 3.42 4

1-055 487 3.90 4

TABLE 15 Compound Retention Chemical Structure No. [M + H] time (min) Method

1-056 522 4.49 4

1-057 501 4.26 4

1-058 556 4.94 4

1-059 555 4.45 4

1-060 555 4.50 4

TABLE 16 Compound Retention Chemical Structure No. [M + H] time (min) Method

1-061 501 3.99 4

1-062 531 3.86 4

1-063 467 2.81 4

1-064 501 2.40 4

1-065 481 3.32 4

TABLE 17 Compound Retention Chemical Structure No. [M + H] time (min) Method

1-066 534 4.30 4

1-067 535 3.60 4

1-068 535 3.60 4

1-069 481 3.91 4

1-070 511 2.76 4

TABLE 18 Compound Retention Chemical Structure No. [M + H] time (min) Method

1-071 522 3.43 4

1-072 556 4.12 4

1-073 536 3.86 4

1-074 591 4.68 4

1-075 590 4.07 4

TABLE 19 Compound Retention Chemical Structure No. [M + H] time (min) Method

1076 590 4.11 4

1-077 536 3.55 4

1-078 566 3.49 4

1-079 483 2.38 4

1-080 517 3.21 4

TABLE 20 Compound Retention Chemical Structure No. [M + H] time (min) Method

1-081 497 2.85 4

1-082 552 3.85 4

1-083 551 3.22 4

1-084 551 3.23 4

1-085 497 2.48 4

TABLE 21 Compound Retention Chemical Structure No. [M + H] time (min) Method

1-086 527 2.29 4

1-087 467 2.75 4

1-088 501 3.54 4

1-089 481 3.19 4

1-090 536 4.15 4

TABLE 22 Compound Retention Chemical Structure No. [M + H] time (min) Method

1-091 535 3.49 4

1-092 535 3.57 4

1-093 481 3.03 4

1-094 511 2.79 4

1-095 419 3.58 4

TABLE 23 Compound Retention Chemical Structure No. [M + H] time (min) Method

1-096 453 4.22 4

1-097 433 4.21 4

1-098 488 4.03 4

1-099 487 3.38 4

1-100 487 4.24 4

TABLE 24 Compound Retention Chemical Structure No. [M + H] time (min) Method

1-101 459 3.38 4

1-102 487 4.16 4

1-103 487 4.18 4

1-104 479 4.69 4

1-105 448 3.38 4

TABLE 25 Compound Retention Chemical Structure No. [M + H] time (min) Method

1-106 462 3.59 4

1-107 490 4.05 4

1-108 488 3.85 4

1-109 496 3.66 4

1-110 530 3.97 4

TABLE 26 Compound Retention Chemical Structure No. [M + H] time (min) Method

1-111 510 3.84 4

1-112 526 3.67 4

1-113 510 3.77 4

1-114 417 2.44 1

1-115 443 2.67 1

TABLE 27 Compound Retention Chemical Structure No. [M + H] time (min) Method

1-116 443 2.59 1

1-117 385 2.52 1

1-118 397 2.44 1

1-119 409 2.52 1

1-120 407 2.70 1

TABLE 28 Compound Retention Chemical Structure No. [M + H] time (min) Method

1-121 409 2.40 1

1-122 407 2.68 1

1-123 390 2.05 1

1-124 436 2.04 1

[-125 433 2.31 1

TABLE 29 Compound Retention Chemical Structure No. [M + H] time (min) Method

1-126 423 2.51 1

1-127 447 2.60 1

1-128 447 2.52 1

1-129 389 2.44 1

1-130 401 2.36 1

TABLE 30 Compound Retention Chemical Structure No. [M + H] time (min) Method

1-131 413 2.44 1

1-132 411 2.60 1

1-133 413 2.31 1

1-134 411 2.58 1

1-135 394 1.96 1

TABLE 31 Compound Retention Chemical Structure No. [M + H] time (min) Method

1-136 440 1.93 1

1-137 437 2.18 1

1-138 409 2.35 1

1-139 407 2.18 1

1-140 433 2.44 1

TABLE 32 Compound Retention Chemical Structure No. [M + H] time (min) Method

1-141 433 2.37 1

1-142 374 2.26 1

1-143 387 2.17 1

1-144 399 2.27 1

1-145 397 2.45 1

TABLE 33 Compound Retention Chemical Structure No. [M + H] time (min) Method

1-146 399 2.13 1

1-147 397 2.42 1

1-148 380 1.78 1

1-149 423 2.04 1

1-150 440 2.40 1

TABLE 34 Compound Retention Chemical Structure No. [M + H] time (min) Method

1-151 438 2.24 1

1-152 464 2.44 1

1-153 407 2.30 1

1-154 418 2.25 1

1-155 430 2.34 1

TABLE 35 Compound Retention Chemical Structure No. [M + H] time (min) Method

1-156 428 2.53 1

1-157 430 2.21 1

1-158 428 2.51 1

1-159 411 1.83 1

1-160 457 1.77 1

TABLE 36 Compound Retention Chemical Structure No. [M + H] time (min) Method

1-161 454 2.04 1

1-162 440 2.40 1

1-163 438 2.24 1

1-164 464 2.48 1

1-165 407 2.31 1

TABLE 37 Compound Retention Chemical Structure No. [M + H] time (min) Method

1-166 430 2. 38 1

1-167 428 2.58 1

1-168 430 2.31 1

1-169 430 2.60 1

1-170 411 1.94 1

TABLE 38 Compound Retention Chemical Structure No. [M + H] time (min) Method

1-171 457 1.92 1

1-172 454 2.20 1

1-173 438 2.30 3

1-174 421 2.38 3

1-175 385 2.20 3

TABLE 39 Compound Retention Chemical Structure No. [M + H] time (min) Method

1-176 423 2.70 3

1-177 439 2.70 3

1-178 373 2.30 3

1-179 389 2.50 3

1-180 385 2.40 3

TABLE 40 Compound Retention Chemical Structure No. [M + H] time (min) Method

1-181 439 2.70 3

1-182 373 2.40 3

1-183 385 2.30 3

1-184 389 2.60 3

1-185 411 2.90 3

TABLE 41 Compound Retention Chemical Structure No. [M + H] time (min) Method

1-186 373 2.40 3

1-187 439 2.70 3

1-188 403 1.20 3

1-189 399 1.20 3

1-190 437 2.10 3

TABLE 42 Compound Retention Chemical Structure No. [M + H] time (min) Method

1-191 399 1.90 3

1-192 399 1.90 3

1-193 403 2.20 3

1-194 403 2.20 3

1-195 437 2.30 3

TABLE 43 Compound Retention Chemical Structure No. [M + H] time (min) Method

1-196 337 1.70 3

1-197 424 2.80 3

1-198 457 2.80 3

1-199 452 1.40 3

1-200 429 2.60 3

TABLE 44 Compound Retention Chemical Structure No. [M + H] time (min) Method

1-201 463 2.70 3

1-202 425 2.40 3

1-203 447 270 3

1-204 481 2.80 3

1-205 376 1.20 3

TABLE 45 Compound Retention Chemical Structure No. [M + H] time (min) Method

1-206 398 1.80 3

1-207 413 2.20 3

1-208 420 2.30 3

1-209 429 2.60 3

1-210 425 2.40 3

TABLE 46 Compound Retention Chemical Structure No. [M + H] time (min) Method

1-211 420 2.40 3

1-212 463 2.70 3

1-213 425 2.40 3

1-214 429 2.60 3

1-215 420 2.40 3

TABLE 47 Compound Retention Chemical Structure No. [M + H] time (min) Method

1-216 463 2.70 3

1-217 427 2.60 3

1-218 454 2.50 3

1-219 413 2.40 3

1-220 451 2.90 3

TABLE 48 Compound Retention Chemical Structure No. [M + H] time (min) Method

1-221 413 2.40 3

1-222 427 2.40 3

1-223 417 2.40 3

1-224 487 2.70 3

1-225 421 2.30 3

TABLE 49 Compound Retention Chemical Structure No. [M + H] time (min) Method

1-226 414 2.60 3

1-227 438 2.50 3

1-228 463 2.90 3

1-229 437 2.40 3

1-230 475 2.60 3

TABLE 50 Compound Retention Chemical Structure No. [M + H] time (min) Method

1-231 417 2.40 3

1-232 447 2.40 3

1-233 417 2.40 3

1-234 465 2.60 3

1-235 464 2.60 3

TABLE 51 Compound Retention Chemical Structure No. [M + H] time (min) Method

1-236 417 2.40 3

1-237 479 2.60 3

1-238 447 2.70 3

1-239 505 2.70 3

1-240 497 3.10 3

TABLE 52 Compound Retention Chemical Structure No. [M + H] time (min) Method

1-241 507 2.70 3

1-242 505 1.60 3

1-243 435 2.60 3

1-244 447 2.80 3

1-245 454 2.70 3

TABLE 53 Compound Retention Chemical Structure No. [M + H] time (min) Method

1-246 428 2.20 3

1-247 470 2.50 3

1-248 429 2.60 3

1-249 428 2.20 3

1-250 470 2.60 3

TABLE 54 Compound Retention Chemical Structure No. [M + H] time (min) Method

1-251 377 2.40 3

1-252 415 2.30 3

1-253 375 2.30 3

1-254 453 2.90 3

1-255 456 2.40 3

TABLE 55 Compound Retention Chemical Structure No. [M + H] time (min) Method

1-256 470 2.50 3

1-257 454 2.20 3

1-258 468 2.40 3

1-259 504 2.50 3

1-260 528 1.50 3

TABLE 56 Compound Retention Chemical Structure No. [M + H] time (min) Method

1-261 482 2.60 3

1-262 484 2.20 3

1-263 428 2.10 3

1-264 482 2.50 3

1-265 442 2.30 3

TABLE 57 Compound Retention Chemical Structure No. [M + H] time (min) Method

1-266 490 2.60 3

1-267 458 2.00 3

1-268 484 2.60 3

1-269 405 2.03 1

[-270 477 2.42 1

TABLE 58 Compound Retention Chemical Structure No. [M + H] time (min) Method

1-271 459 2.49 1

1-272 476 1.44 1

1-273 449 1.96 1

1-274 507 1.98 1

1-275 503 2.27 1

TABLE 59 Compound Retention Chemical Structure No. [M + H] time (min) Method

1-276 493 1.85 1

1-277 433 2.34 1

1-278 440 1.70 1

1-279 439 1.90 1

1-280 463 2.21 1

TABLE 60 Compound Retention Chemical Structure No. [M + H] time (min) Method

1-281 518 1.47 1

1-282 516 1.50 1

1-283 513 1.82 1

1-284 463 1.96 1

1-285 463 2.00 1

TABLE 61 Compound Retention Chemical Structure No. [M + H] time (min) Method

1-286 479 1.80 1

1-287 509 1.30 1

1-288 444 2.15 1

1-289 477 2.00 1

1-290 448 1.40 1

TABLE 62 Compound Retention Chemical Structure No. [M + H] time (min) Method

1-291 458 2.15 1

1-292 489 1.90 1

1-293 490 2.00 1

1-294 476 1.91 1

1-295 462 1.85 1

TABLE 63 Compound Retention Chemical Structure No. [M + H] time (min) Method

1-296 447 2.18 1

1-297 504 2.04 1

1-298 490 1.90 1

1-299 476 1.86 1

1-300 496 2.06 1

TABLE 64 Compound Retention Chemical Structure No. [M + H] time (min) Method

1-301 495 2.53 1

1-302 417 1.50 1

1-303 417 1.60 1

1-304 434 1.50 1

1-305 421 1.69 1

TABLE 65 Compound Retention Chemical Structure No. [M + H] time (min) Method

1-306 444 1.11 1

1-307 417 1.72 1

1-308 391 1.80 1

1-309 457 2.09 1

1-310 455 2.21 1

TABLE 66 Compound Rentention Chemical Structure No. [M + H] time (min) Method

1-311 456 1.14 1

1-312 435 1.83 1

1-313 441 2.00 2

1-314 440 1.70 2

1-315 459 2.09 2

TABLE 67 Compound Retention Chemical Structure No. [M + H] time (min) Method

1-316 409 1.84 2

1-317 462 1.40 2

1-318 415 2.01 2

1-319 379 1.68 2

1-320 431 1.83 2

TABLE 68 Compound Retention Chemical Structure No. [M + H] time (min) Method

1-321 449 1.99 2

1-322 457 2.03 2

1-323 463 2.16 2

1-324 473 1.61 2

1-325 325 1.10 2

TABLE 69 Compound Retention Chemical Structure No. [M + H] time (min) Method

1-326 504 1.93 2

1-327 472 1.03 2

1-328 429 2.15 2

1-329 439 1.80 2

1-330 428 1.56 2

TABLE 70 Compound Retention Chemical Structure No. [M + H] time (min) Method

1-331 490 1.49 2

1-332 491 2.26 2

[-333 433 1.80 2

1-334 465 2.35 3

1-335 489 2.19 2

TABLE 71 Compound Retention Chemical Structure No. [M + H] time (min) Method

1-336 373 1.61 2

1-337 362 2.39 2

1-338 477 2.45 3

1-339 451 1.88 2

1-340 451 1.84 2

TABLE 72 Compound Retention Chemical Structure No. [M + H] time (min) Method

1-341 467 2.01 2

1-342 548 2.81 3

1-343 525 2.50 2

1-344 429 2.48 3

1-345 412 2.74 2

TABLE 73 Compound Retention Chemical Structure No. [M + H] time (min) Method

1-346 445 2.34 2

1-347 460 1.78 2

1-348 447 2.45 2

1-349 413 2.20 2

1-350 549 2.55 2

TABLE 74 Compound Retention Chemical Structure No. [M + H] time (min) Method

1-351 465 2.06 2

1-352 520 1.78 2

1-353 506 1.77 2

1-354 521 2.47 2

1-355 493 2.10 2

TABLE 75 Compound Retention Chemical Structure No. [M + H] time (min) Method

1-356 505 2.33 2

1-357 455 2.07 2

1-358 442 2.23 2

1-359 445 1.85 2

1-360 453 1.84 2

TABLE 76 Compound Retention Chemical Structure No. [M + H] time (min) Method

1-361 431 1.77 2

1-362 479 2.12 2

1-363 491 2.05 2

1-364 505 2.12 2

1-365 477 2.03 2

TABLE 77 Compound Retention Chemical Structure No. [M + H] time (min) Method

I-366 473 2.33 3

I-367 485 2.17 3

I-368 475 2.00 3

I-369 510 2.24 3

I-370 483 1.98 3

TABLE 78 Compound Retention Chemical Structure No. [M + H] time (min) Method

I-371 461 1.88 3

I-372 396 2.27 2

I-373 443 2.17 2

I-374 491 2.28 2

I-375 473 2.32 3

TABLE 79 Compound Retention Chemical Structure No. [M + H] time (min) Method

I-376 453 2.30 3

I-377 446 1.41 2

I-378 415 2.02 2

I-379 447 2.11 2

I-380 493 2.49 2

TABLE 80 Compound Retention Chemical Structure No. [M + H] time (min) Method

I-381 440 3.04 3

I-382 465 2.09 2

I-383 457 2.32 3

I-384 440 2.77 2

I-385 463 1.56 2

TABLE 81 Compound Retention Chemical Structure No. [M + H] time (min) Method

I-386 491 1.81 2

I-387 505 1.86 2

I-388 519 1.98 2

I-389 519 1.94 2

I-390 535 1.77 2

TABLE 82 Compound Retention Chemical Structure No. [M + H] time (min) Method

I-391 531 1.89 2

I-392 549 1.77 2

I-393 406 2.28 2

I-394 430 2.30 2

I-395 549 2.77 3

TABLE 83 Compound Retention Chemical Structure No. [M + H] time (min) Method

I-396 398 2.03 2

I-397 534 1.94 2

I-398 536 1.69 2

I-399 535 2.51 2

I-400 520 1.81 2

TABLE 84 Compound Retention Chemical Structure No. [M + H] time (min) Method

I-401 521 2.24 2

I-402 527 2.49 2

I-403 519 2.40 2

I-404 499 2.32 2

I-405 485 2.04 2

TABLE 85 Compound Retention Chemical Structure No. [M + H] time (min) Method

I-406 609 2.74 2

I-407 625 2.84 2

I-408 501 2.16 2

I-409 471 2.13 2

I-410 457 2.09 2

TABLE 86 Compound Retention Chemical Structure No. [M + H] time (min) Method

I-411 457 1.92 2

I-412 443 1.87 2

I-413 503 2.10 2

I-414 516 1.63 2

I-415 528 1.84 2

TABLE 87 Compound Retention Chemical Structure No. [M + H] time (min) Method

I-416 500 1.74 2

I-417 514 1.78 2

I-418 514 1.79 2

I-419 526 1.78 2

I-420 519 2.21 2

TABLE 88 Compound Retention Chemical Structure No. [M + H] time (min) Method

I-421 535 2.32 2

I-422 531 2.45 2

I-423 547 2.53 2

I-424 503 2.09 2

I-425 519 2.20 2

TABLE 89 Compound Retention Chemical Structure No. [M + H] time (min) Method

I-426 493 1.99 2

I-427 496 2.12 2

I-428 500 1.25 2

I-429 479 1.72 2

I-430 482 1.85 2

TABLE 90 Compound Retention Chemical Structure No. [M + H] time (min) Method

I-431 515 2.44 2

I-432 501 2.15 2

I-433 435 2.10 1

II-001 462 1.79 1

II-002 449 1.80 1

TABLE 91 Compound Retention Chemical Structure No. [M + H] time (min) Method

II-003 494 1.90 1

II-004 590 3.40 1

II-005 448 1.50 2

II-006 464 1.80 2

II-007 462 1.50 2

TABLE 92 Compound Retention Chemical Structure No. [M + H] time (min) Method

II-008 493 1.70 2

II-009 479 1.88 1

II-010 521 2.09 1

TABLE 93 Compound Retention Chemical Structure No. [M + H] time (min) Method

I-434 479 2.06 2

I-435 517 2.21 3

I-436 492 2.16 3

I-437 522 2.03 3

I-438 535 1.98 3

TABLE 94 Compound Retention Chemical Structure No. [M + H] time (min) Method

I-439 515 2.11 3

I-440 533 1.87 3

I-441 521 2.43 2

I-442 487 2.23 2

I-443 509 2.5 3

TABLE 95 Compound Retention Chemical Structure No. [M + H] time (min) Method

I-444 553 2.61 3

I-445 539 2.33 3

I-446 507 2.31 2

I-447 473 2.1 2

I-448 495 2.22 2

TABLE 96 Compound Retention Chemical Structure No. [M + H] time (min) Method

I-449 511 2.67 2

I-450 553 2.63 3

I-451 539 2.36 3

I-452 505 2.29 2

I-453 505 2.3 2

TABLE 97 Compound Retention Chemical Structure No. [M + H] time (min) Method

I-454 567 2.74 3

I-455 491 2.22 3

I-456 491 2.22 3

I-457 521 2.41 2

I-458 521 2.41 2

TABLE 98 Compound Retention Chemical Structure No. [M + H] time (min) Method

I-459 539 2.38 3

I-460 507 2.34 3

I-461 507 2.33 3

I-462 501 2.33 2

I-463 471 2.31 2

TABLE 99 Compound Retention Chemical Structure No. [M + H] time (min) Method

I-464 457 2.02 2

I-465 487 2.06 2

I-466 477 2.41 2

I-467 527 2.5 2

I-468 463 2.29 3

TABLE 100 Compound Retention Chemical Structure No. [M + H] time (min) Method

I-469 513 2.41 3

I-470 482 2.15 3

I-471 511 2.63 3

I-472 512 2.75 3

I-473 502 1.78 2

TABLE 101 Compound Retention Chemical Structure No. [M + H] time (min) Method

I-474 491 2.42 3

I-475 477 2.18 3

I-476 497 2.2 2

I-477 499 2.31 2

I-478 468 1.71 2

TABLE 102 Compound Retention Chemical Structure No. [M + H] time (min) Method

I-479 487 2.17 2

I-480 473 2.06 2

I-481 487 2.22 2

I-482 488 1.53 2

I-483 473 1.93 2

TABLE 103 Compound Retention Chemical Structure No. [M + H] time (min) Method

I-484 459 1.82 2

I-485 473 1.98 2

I-486 487 2.08 2

I-487 493 2.03 2

I-488 498 1.98 2

TABLE 104 Compound Retention Chemical Structure No. [M + H] time (min) Method

I-489 497 2.28 2

I-490 534 1.62 2

I-491 483 2 2

I-492 510 2.23 2

I-493 496 1.96 2

TABLE 105 Compound Retention Chemical Structure No. [M + H] time (min) Method

I-494 498 2.04 2

I-495 520 1.43 2

I-496 484 1.75 2

I-497 484 1.74 2

I-498 535 2.5 2

TABLE 106 Compound Retention Chemical Structure No. [M + H] time (min) Method

I-499 401 2.03 2

I-500 507 2.13 2

I-501 383 1.85 2

I-502 515 2.41 2

I-503 487 2.06 2

TABLE 107 Compound Retention Chemical Structure No. [M + H] time (min) Method

I-504 497 2.25 2

I-505 469 1.89 2

I-506 538 2.44 2

I-507 524 2.34 2

I-508 524 2.17 2

TABLE 108 Compound Retention Chemical Structure No. [M + H] time (min) Method

I-509 510 2.07 2

I-510 475 2.23 3

I-511 441 2.67 3

I-512 533 2.75 3

I-513 533 2.75 3

TABLE 109 Compound Retention Chemical Structure No. [M + H] time (min) Method

I-514 519 2.5 3

I-515 485 2.4 3

I-516 516 2.62 3

I-517 471 2.18 3

I-518 487 2.28 3

TABLE 110 Compound Retention Chemical Structure No. [M + H] time (min) Method

I-519 487 2.25 3

I-520 449 2 3

I-521 495 2.55 3

I-522 521 2.64 3

I-523 505 2.53 3

TABLE 111 Compound Retention Chemical Structure No. [M + H] time (min) Method

I-524 501 2.57 3

I-525 467 2.2 3

I-526 507 2.38 3

I-527 491 2.26 3

I-528 487 2.3 3

TABLE 112 Compound Retention Chemical Structure No. [M + H] time (min) Method

I-529 487 2.18 2

I-530 473 2.07 2

I-531 501 2.33 2

I-532 487 2.23 2

I-533 507 2.29 2

TABLE 113 Compound Retention Chemical Structure No. [M + H] time (min) Method

I-534 483 2.16 2

I-535 459 1.82 2

I-536 473 1.98 2

I-537 473 1.91 2

I-538 487 2.09 2

TABLE 114 Compound Retention Chemical Structure No. [M + H] time (min) Method

I-539 493 2.03 2

I-540 469 1.91 2

I-541 487 1.99 2

I-542 473 1.9 2

I-543 495 1.97 2

TABLE 115 Compound Retention Chemical Structure No. [M + H] time (min) Method

I-544 475 1.99 2

I-545 533 2.41 2

I-546 547 2.76 2

I-547 507 2.53 2

I-548 493 2.42 2

TABLE 116 Compound Retention Chemical Structure No. [M + H] time (min) Method

I-549 521 2.65 2

I-550 493 2.43 2

I-551 493 2.23 2

I-552 479 2.16 2

I-553 507 2.35 2

TABLE 117 Compound Retention Chemical Structure No. [M + H] time (min) Method

I-554 479 2.12 2

I-555 473 2.37 2

I-556 521 2.44 2

I-557 501 2.37 2

I-558 483 2.16 2

TABLE 118 Compound Retention Chemical Structure No. [M + H] time (min) Method

I-559 459 2.09 2

I-560 505 2.34 2

I-561 507 2.18 2

I-562 491 2.28 3

I-563 487 2.32 3

TABLE 119 Compound Retention Chemical Structure No. [M + H] time (min) Method

  I-564 469 2.11 3

  I-565 477 2.41 3

II-011 478 1.74 2

II-012 488 2.44 2

II-013 476 2.04 2

TABLE 120 Compound Retention Chemical Structure No. [M + H] time (min) Method

II-014 449 2.21 2

II-015 All 2.07 2

II-016 419 2.28 2

II-017 463 1.78 2

II-018 506 1.62 2

TABLE 121 Compound Retention Chemical Structure No. [M + H] time (min) Method

II-019 505 1.72 2

II-020 536 1.56 2

II-021 533 1.4 2

II-022 520 1.65 2

II-023 462 1.66 2

TEST EXAMPLES

Stably expressing cell line (C6BU-1 cell transfected with human P2X₃ receptor gene (GenBank accession number Y07683)) was used. The cells were seeded in a 96-well microtiter plate at a concentration of 8000 cells/well and cultured in the medium (8.3% fetal bovine serum, 8.3% horse serum, 1% antibiotic and antifungal in DMEM) for one day at 37° C. under 5% carbon dioxide atmosphere. The medium was replaced with 4 μM Fluo-3-AM solution (pH7.5) containing 20 mM HEPES, 137 mM NaCl, 2.7 mM KCl, 0.9 mM MgCl₂, 5.0 mM CaCl₂, 5.6 mM D-glucose, 2.5 mM probenecid, 10% BSA, and 0.08% Pluronic F-127, and incubated at 37° C. under 5% dioxide carbon atmosphere for one hour. The plate was washed with washing buffer (20 mM HEPES, 137 mM NaCl, 2.7 mM KCl, 0.9 mM MgCl₂, 5.0 mM CaCl₂, 5.6 mM D-glucose, 2.5 mM probenecid, pH7.5), and each well was added with 40 μL of this buffer. The plate was placed in High-Throughput Screening System FDSS 3000 (Hamamatsu Photonics K.K.). Measurement of fluorescence intensity by FDSS 3000 was started, and 40 μL of DMSO solutions containing different concentrations of the test compound as prepared by dilution with dilution buffer (20 mM HEPES, 137 mM NaCl, 2.7 mM KCl, 0.9 mM MgCl₂, 5.0 mM CaCl₂, 5.6 mM D-glucose, 2.5 mM probenecid, 0.1% Pluronic F-127, pH7.5) were dispensed to each well through the built-in automatic dispenser. Five minutes after, 40 nM ATP solution (50 μL) prepared by dilution with the dilution buffer was dispensed through the built-in automatic dispenser, and the measurement of fluorescence intensity was continued for 3 min. For each well, the specific maximum fluorescence intensity was calculated as the ratio of the maximum fluorescence intensity after addition of the ATP solution to the fluorescence intensity at the starting of the measurement. The 50% inhibitory concentration (IC₅₀) was calculated under the assumption that the specific maximum fluorescence intensity without test compound is 0% inhibition and that the specific maximum fluorescence intensity when the dilution buffer was added in place of ATP solution is 100% inhibition, to evaluate the inhibitory activity of the test compound. FDSS software (Hamamatsu Photonics K.K.) was used for calculation of the specific maximum fluorescence intensity. IC₅₀ was calculated using Microsoft™ Excel™ (Microsoft Corporation) and XLfit™ (ID Business Solutions Ltd.) The results of the compounds of the invention are shown in the following tables.

TABLE 122 Compound P2X3 No. IC50 (μM) I-020 0.389 I-021 0.197 I-029 0.595 I-097 0.505 I-116 0.484 I-117 0.387 I-118 0.231 I-121 0.246 I-123 0.815 I-126 0.689 I-128 0.840 I-130 0.953 I-133 0.339 I-138 0.619 I-141 0.685 I-162 0.379 I-164 0.860 I-181 0.985 I-182 0.714 I-200 0.128 I-203 0.110 I-204 0.558 I-217 0.268 I-218 0.505 I-221 0.276 I-223 0.909 I-227 0.970 I-228 0.031 I-234 0.298 I-235 0.985 I-237 0.230 I-238 0.658 I-239 0.116 I-240 0.953 I-241 0.447 I-242 0.787 I-243 0.450 I-244 0.045 I-245 0.168 I-246 0.996 I-248 0.420 I-254 0.144 I-255 0.520 I-256 0.867 I-257 0.682 I-258 0.683 I-266 0.861 I-269 0.415 I-270 0.271 I-271 0.032 I-272 0.180 I-273 0.038 I-274 0.009 I-275 0.021 I-276 0.012 I-277 0.038 I-278 0.931 I-280 0.030 I-281 0.012 I-282 0.027 I-283 0.019 I-284 0.629 I-285 0.014 I-286 0.277 I-287 0.222 I-288 0.093 I-289 0.066 I-290 0.266 I-291 0.009 I-292 0.034 I-293 0.351 I-294 0.040 I-295 0.046 I-296 0.176 I-297 0.045 I-298 0.027 I-299 0.046 I-300 0.025 I-301 0.048 I-305 0.946 I-307 0.250 I-309 0.357 I-310 0.389 I-311 0.142 I-312 0.104 I-313 0.178 I-314 0.555 I-315 0.183 I-316 0.712 I-317 0.137 I-320 0.083 I-321 0.033 I-322 0.112 I-323 0.148 I-324 0.309 I-325 0.665 I-326 0.011 I-328 0.124 I-329 0.266 I-330 0.594 I-331 0.066 I-332 0.008 I-333 0.192 I-334 0.099 I-335 0.007 I-338 0.053 I-339 0.775 I-340 0.336 I-341 0.149 I-342 0.005 I-343 0.021 I-344 0.128 I-346 0.016 I-347 0.251 I-348 0.013 I-349 0.113 I-350 0.010 I-351 0.015 I-352 0.036 I-353 0.018 I-354 0.008 I-355 0.020 I-356 0.012 I-357 0.047 I-358 0.055 I-359 0.040 I-360 0.148 I-361 0.076 I-362 0.007 I-363 0.078 I-364 0.030 I-365 0.018 I-366 0.046 I-367 0.040 I-368 0.041 I-369 0.007 I-370 0.154 I-371 0.063 I-372 0.964 I-373 0.185 I-374 0.080 I-375 0.152 I-377 0.755 I-378 0.347 I-379 0.330 I-380 0.034 I-382 0.096 I-383 0.532 I-385 0.908 I-386 0.041 I-387 0.037 I-388 0.036 I-389 0.064 I-390 0.067 I-391 0.133 I-392 0.038 I-394 0.435 I-397 0.019 I-398 0.007 I-399 0.008 I-400 0.044 I-401 0.007 I-402 0.443 I-403 0.015 I-404 0.012 I-405 0.032 I-406 0.030 I-407 0.027 I-408 0.010 I-409 0.012 I-410 0.044 I-411 0.061 I-413 0.099 I-414 0.007 I-415 0.314 I-416 0.035 I-417 0.035 I-418 0.200 I-419 0.071 I-420 0.053 I-421 0.019 I-422 0.006 I-423 0.004 I-424 0.049 I-425 0.016 I-426 0.211 I-427 0.678 I-429 0.779 I-431 0.004 I-432 0.026 I-433 0.199 II-002 0.079 II-006 0.398 II-008 0.943 II-009 0.034 II-010 0.349

TABLE 123 Compound P2X3 No. IC50 (μM) I-434 0.407 I-435 0.006 I-436 0.008 I-437 0.006 I-438 0.005 I-439 0.018 I-440 0.055 I-441 0.011 I-442 0.117 I-443 0.207 I-444 0.017 I-445 0.008 I-446 0.020 I-447 0.279 I-448 0.388 I-450 0.036 I-451 0.016 I-452 0.003 I-453 0.005 I-454 0.024 I-455 0.030 I-456 0.008 I-457 0.003 I-458 0.004 I-459 0.039 I-460 0.016 I-461 0.009 I-462 0.004 I-463 0.074 I-464 0.564 I-465 0.057 I-466 0.037 I-467 0.037 I-468 0.137 I-469 0.101 I-470 0.080 I-471 0.024 I-472 0.047 I-473 0.583 I-474 0.014 I-475 0.571 I-476 0.035 I-477 0.056 I-478 0.629 I-479 0.007 I-480 0.012 I-481 0.012 I-483 0.100 I-484 0.290 I-485 0.198 I-486 0.042 I-487 0.027 I-488 0.124 I-489 0.010 I-490 0.046 I-491 0.027 I-492 0.102 I-493 0.952 I-494 0.034 I-495 0.125 I-496 0.125 I-497 0.458 I-498 0.009 I-499 0.137 I-500 0.013 I-501 0.191 I-502 0.020 I-503 0.050 I-504 0.015 I-505 0.120 I-506 0.279 I-507 0.301 I-508 0.511 I-509 0.652 I-510 0.098 I-515 0.006 I-516 0.005 I-517 0.015 I-518 0.007 I-519 0.012 I-520 0.080 I-521 0.004 I-522 0.029 I-523 0.072 I-524 0.060 I-525 0.054 I-526 0.024 I-527 0.033 I-528 0.053 I-529 0.022 I-530 0.034 I-531 0.010 I-532 0.029 I-533 0.010 I-534 0.018 I-535 0.052 I-536 0.046 I-537 0.019 I-538 0.016 I-539 0.007 I-540 0.027 I-541 0.058 I-542 0.096 I-543 0.172 I-544 0.601 I-545 0.006 I-546 0.459 I-547 0.011 I-548 0.012 I-549 0.019 I-550 0.033 I-551 0.034 I-552 0.023 I-553 0.034 I-554 0.139 I-555 0.013 I-556 0.005 I-557 0.019 I-558 0.005 I-559 0.097 I-560 0.007 I-561 0.008 I-562 0.027 I-563 0.040 I-564 0.048 II-012 0.568 II-013 0.430 II-014 0.254 II-015 0.614

Test Examples2 CYP3A4 Fluorescent MBI Test

The CYP3A4 fluorescent MBI test is a test of investigating enhancement of CYP3A4 inhibition of a compound by a metabolism reaction, and the test was performed using, as CYP3A4 enzyme expressed in Escherichia coli and employing, as an index, a reaction in which 7-benzyloxytrifluoromethylchmarin (7-BFC) is debenzylated by the CYP3A4 enzyme to produce a metabolite, 7-hydroxytrifluoromethylchmarin (HFC) emitting fluorescent light.

The reaction conditions were as follows: substrate, 5.6 μmol/L 7-BFC; pre-reaction time, 0 or 30 minutes; reaction time, 15 minutes; reaction temperature, 25° C. (room temperature); CYP3A4 content (expressed in Escherichia coli), at pre-reaction 62.5 pmol/mL, at reaction 6.25 pmol/mL (at 10-fold dilution); test drug concentration, 0.625, 1.25, 2.5, 5, 10, 20 μmol/L (six points).

An enzyme in a K-Pi buffer (pH 7.4) and a test drug solution as a pre-reaction solution were added to a 96-well plate at the composition of the pre-reaction, a part of it was transferred to another 96-well plate so that it was 1/10 diluted by a substrate in a K-Pi buffer, NADPH as a co-factor was added to initiate a reaction as an index (without preincubation) and, after a predetermined time of a reaction, acetonitrile/0.5 mol/L Tris (trishydroxyaminomethane)=4/1 was added to stop the reaction. In addition, NADPH was added to a remaining preincubation solution to initiate a preincubation (with preincubation) and, after a predetermined time of a preincubation, a part was transferred to another plate so that it was 1/10 diluted with a substrate and a K-Pi buffer to initiate a reaction as an index. After a predetermined time of a reaction, acetonitrile/0.5 mol/L Tris (trishydroxyaminomethane)=4/1 was added to stop the reaction. For the plate on which each index reaction had been performed, a fluorescent value of 7-HFC which is a metabolite was measured with a fluorescent plate reader. (Ex=420 nm, Em=535 nm).

Addition of only DMSO which is a solvent dissolving a drug to a reaction system was adopted as a control (100%), remaining activity (%) was calculated at each concentration of a test drug added as the solution, and IC₅₀ was calculated by reverse-presumption by a logistic model using a concentration and an inhibition rate. When a difference between IC₅₀ values is 5 μM or more, this was defined as (+) and, when the difference is 3 μM or less, this was defined as (−).

Test Examples3 CYP Inhibition Test

Using commercially available pooled human hepatic microsome, and employing, as markers, 7-ethoxyresorufin O-deethylation (CYP1A2), tolbutamide methyl-hydroxylation (CYP2C9), mephenytoin 4′-hydroxylation (CYP2C19), dextromethorphan O-demethylation (CYP2D6), and terfenedine hydroxylation as typical substrate metabolism reactions of human main five CYP enzyme forms (CYP1A2, 2C9, 2C19, 2D6, 3A4), an inhibitory degree of each metabolite production amount by a test compound was assessed.

The reaction conditions were as follows: substrate, 0.5 μmol/L ethoxyresorufin (CYP1A2), 100 μmol/L tolbutamide (CYP2C9), 50 μmol/L S-mephenitoin (CYP2C19), 5 μmol/L dextromethorphan (CYP2D6), 1 μmol/L terfenedine (CYP3A4); reaction time, 15 minutes; reaction temperature, 37° C.; enzyme, pooled human hepatic microsome 0.2 mg protein/mL; test drug concentration, 1, 5, 10, 20 μmol/L (four points).

Each five kinds of substrates, human hepatic microsome, or a test drug in 50 mM Hepes buffer as a reaction solution was added to a 96-well plate at the composition as described above, NADPH, as a cofactor was added to initiate metabolism reactions as markers and, after the incubation at 37° C. for 15 minutes, a methanol/acetonitrile=1/1 (v/v) solution was added to stop the reaction. After the centrifugation at 3000 rpm for 15 minutes, resorufin (CYP1A2 metabolite) in the supernatant was quantified by a fluorescent multilabel counter and tributamide hydroxide (CYP2CP metabolite), mephenytoin 4′ hydroxide (CYP2C19 metabolite), dextromethorphan (CYP2D6 metabolite), and terfenadine alcohol (CYP3A4 metabolite) were quantified by LC/MS/MS.

Addition of only DMSO being a solvent dissolving a drug to a reaction system was adopted as a control (100%), remaining activity (%) was calculated at each concentration of a test drug added as the solution and IC₅₀ was calculated by reverse presumption by a logistic model using a concentration and an inhibition rate.

Test Examples4 FAT Test

20 μL of freezing-stored rat typhoid bacillus (Salmonella typhimurium TA98 strain, TA100 strain) was inoculated on 10 mL of a liquid nutrient medium (2.5% Oxoid nutrient broth No. 2), and this was cultured before shaking at 37° C. for 10 hours. 9 mL of a bacterial solution of the TA98 strain was centrifuged (2000×g, 10 minutes) to remove a culturing solution, the bacteria was suspended in 9 mL of a Micro F buffer (K₂HPO₄: 3.5 g/L, KH₂PO₄: 1 g/L, (NH₄)₂SO₄: 1 g/L, trisodium citrate dehydrate: 0.25 g/L, MgSO₄.7H₂O: 0.1 g/L), the suspension was added to 110 mL of an Exposure medium (Micro F buffer containing Biotin: 8 μg/mL, histidine: 0.2 μg/mL, glucose: 8 mg/mL), and the TA100 strain was added to 120 mL of the Exposure medium relative to 3.16 mL of the bacterial solution to prepare a test bacterial solution. Each 12 μL of a test substance DMSO solution (8 stage dilution from maximum dose 50 mg/mL at 2-fold ratio), DMSO as a negative control, 50 g/mL of 4-nitroquinoline-1-oxide DMSO solution for the TA98 strain, 0.25 μg/mL of 2-(furyl)-3-(5-nitro-2-furyl)acrylamide DMSO solution for the TA100 strain under the non-metabolism activating condition, 40 g/mL of 2-aminoanthracene DMSO solution for the TA98 strain, 20 g/mL of 2-aminoanthracene DMSO solution for the TA100 strain under the metabolism activating condition as a positive control, and 588 μL of the test bacterial solution (a mixed solution of 498 Cl of the test bacterial solution and 90 μL of S9 mix under the metabolism activating condition) were mixed, and this was shaking-cultured at 37° C. for 90 minutes. 460 μL of the bacterial solution exposed to the test substance was mixed with 2300 μL of an Indicator medium (Micro F buffer containing biotin: 8 μg/mL, histidine: 0.2 μg/mL, glucose: 8 mg/mL, Bromo Cresol Purple: 37.5 g/mL), each 50 μL was dispensed into microplate 48 wells/dose, and this was subjected to stationary culturing at 37° C. for 3 days. Since a well containing a bacterium which has obtained the proliferation ability by mutation of an amino acid (histidine) synthesizing enzyme gene turns from purple to yellow due to a pH change, the bacterium proliferation well which has turned to yellow in 48 wells per dose is counted, and was assessed by comparing with a negative control group.

Test Examples 5 Solubility Test

The solubility of a compound is determined under a condition in which 1% DMSO is added. 10 mM compound solution is prepared using DMSO, and then 6 μL of the compound solution is added to 594 μL of artificial intestinal juice in pH 6.8 (to 250 mL of 0.2 mol/L potassium dihydrogen phosphate reagent solution is added 118 mL of 0.2 mol/L NaOH reagent solution and water to provide a final volume of 1000 mL). After standing at 25 degrees Celsius for 16 hours, the mixed solution is filtrated with suction. The filtrate is diluted twice with methanol/water (1/1), and then a concentration in the filtration is measured with HPLC or LC/MS/MS by the absolute calibration method.

Test Examples 6 Metabolism Stability Test

Using commercially available pooled human hepatic microsomes, a test compound was reacted for a constant time, a remaining rate was calculated by comparing a reacted sample and an unreacted sample, thereby, a degree of metabolism in liver was assessed.

A reaction was performed (oxidative reaction) at 37° C. for 0 minute or 30 minutes in the presence of 1 mmol/L NADPH in 0.2 mL of a buffer (50 mmol/L Tris-HCl pH 7.4, 150 mmol/L potassium chloride, 10 mmol/L magnesium chloride) containing 0.5 mg protein/mL of human liver microsomes. After the reaction, 50 μL of the reaction solution was added to 100 μL of a methanol/acetonitrile=1/1 (v/v), mixed and centrifuged at 3000 rpm for 15 minutes. The test compound in the supernatant was quantified by LC/MS/MS, and a remaining amount of the test compound after the reaction was calculated, letting a compound amount at 0 minute reaction time to be 100%.

Test Examples 7 Herg Test

For the purpose of assessing risk of an electrocardiogram QT interval prolongation, effects on delayed rectifier K+ current (I_(Kr)), which plays an important role in the ventricular repolarization process, was studied using HEK293 cells expressing human ether-a-go-go related gene (hERG) channel.

After a cell was retained at a membrane potential of −80 mV by whole cell patch clamp method using an automated patch clamp system (PatchXpress 7000A, Axon Instruments Inc.), I_(Kr) induced by depolarization pulse stimulation at +40 mV for 2 seconds and, further, repolarization pulse stimulation at −50 mV for 2 seconds was recorded. After the generated current was stabilized, extracellular solution (NaCl: 135 mmol/L, KCl: 5.4 mmol/L, NaH₂PO₄: 0.3 mmol/L, CaCl₂.2H₂O: 1.8 mmol/L, MgCl₂.6H₂O: 1 mmol/L, glucose: 10 mmol/L, HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid): 10 mmol/L, pH=7.4) in which the test compound had been dissolved at an objective concentration was applied to the cell under the room temperature condition for 10 minutes. From the recording I_(Kr), an absolute value of the tail peak current was measured based on the current value at the resting membrane potential using an analysis software (DataXpress ver. 1, Molecular Devices Corporation). Further, the % inhibition relative to the tail peak current before application of the test substance was calculated, and compared with the vehicle-applied group (0.1% dimethyl sulfoxide solution) to assess influence of the test substance on I_(Kr).

Test Example 8 Metabolism Stability Test

Using a prepared frozen rat hepatocyte, a test compound is reacted for a constant time, a remaining rate is calculated by comparing a reacted sample and an unreacted sample, thereby, a degree of metabolism in liver is assessed.

A reaction is performed at 37° C. for 0, 1 or 2 hours in William's E medium containing rat frozen hepatocyte 1.0×10⁶ cells/mL. After the reaction, 50 μL of the reaction solution is added to 100 μL of a methanol/acetonitrile=1/1 (v/v), mixed and centrifuged at 3000 rpm for 15 minutes. The test compound in the supernatant is quantified by LC/MS/MS, and a remaining amount of the test compound after the reaction is calculated, letting a compound amount at 0 minute reaction time to be 100%.

As shown, the compounds of the invention showed inhibiting activity on P2X₃ receptor. Furthermore, as the compounds of the invention can be effective to P2X₃ subtype, the compounds also have inhibiting activity on P2X_(2/3) receptor, which comprises P2X₃ subtype.

INDUSTRIAL APPLICABILITY

The compound of the invention has antagonizing effect on P2X₃ and/or P2X_(2/3) receptor and is useful in the treatment of diseases or conditions associated with a P2X₃ and/or P2X_(2/3) receptor, such as chronic pain, overactive bladder, etc. 

The invention claimed is:
 1. A method for treating pain or overactive bladder, the method comprising: administering a compound represented by formula (II):

wherein R^(1c) is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted acyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, a substituted or unsubstituted non-aromatic heterocyclic group, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; R^(4a) and R^(4b) are each independently hydrogen; —X— is N(R⁵)—; R⁵ is hydrogen; ═Z is ═O; n is an integer of 1 to 2; R² is substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; R³ is a group represented by the formula:

wherein ring A is aryl or heteroaryl; s is an integer of 0 to 3; and R⁹ is each independently halogen, hydroxy, cyano, nitro, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkyloxy, substituted or unsubstituted alkenyloxy, substituted or unsubstituted alkynyloxy, substituted or unsubstituted alkylthio, substituted or unsubstituted alkenylthio, substituted or unsubstituted alkynylthio, substituted or unsubstituted acyl, carboxy, substituted or unsubstituted alkyloxycarbonyl, substituted or unsubstituted alkenyloxycarbonyl, substituted or unsubstituted alkynyloxycarbonyl, substituted or unsubstituted carbamoyl, substituted or unsubstituted amino, substituted or unsubstituted sulfamoyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, a substituted or unsubstituted non aromatic heterocyclic group, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted cycloalkyloxy, substituted or unsubstituted cycloalkenyloxy, substituted or unsubstituted non-aromatic heterocyclic ring-oxy, substituted or unsubstituted aryloxy, or substituted or unsubstituted heteroaryloxy, or a pharmaceutically acceptable salt thereof, to a patient in need thereof.
 2. The method of claim 1, wherein R^(1c) is hydrogen; unsubstituted alkyl; or alkyl substituted with one or more substituents selected from the group consisting of halogen, hydroxy, substituted or unsubstituted alkyloxy, substituted or unsubstituted alkenyloxy, substituted or unsubstituted alkynyloxy, substituted or unsubstituted alkylthio, substituted or unsubstituted alkenylthio, substituted or unsubstituted alkynylthio, substituted or unsubstituted acyl, carboxy, substituted or unsubstituted alkyloxycarbonyl, substituted or unsubstituted alkenyloxycarbonyl, substituted or unsubstituted alkynyloxycarbonyl, substituted or unsubstituted cycloalkyloxycarbonyl, substituted or unsubstituted cycloalkenyloxycarbonyl, substituted or unsubstituted non-aromatic heterocyclic ring-oxy-carbonyl, substituted or unsubstituted aryloxycarbonyl, substituted or unsubstituted heteroaryloxycarbonyl, substituted or unsubstituted carbamoyl, substituted or unsubstituted amino, substituted or unsubstituted sulfamoyl, cyano, nitro, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, a substituted or unsubstituted non aromatic heterocyclic group, substituted or unsubstituted aryl and substituted or unsubstituted heteroaryl, or a pharmaceutically acceptable salt thereof.
 3. The method of claim 1, wherein R³ is a group represented by the formula:

wherein R^(9a) and R^(9b) are each independently halogen, hydroxy, cyano, nitro, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted alkyloxy, substituted or unsubstituted alkenyloxy, substituted or unsubstituted alkynyloxy, substituted or unsubstituted alkylthio, substituted or unsubstituted alkenylthio, substituted or unsubstituted alkynylthio, substituted or unsubstituted acyl, carboxy, substituted or unsubstituted alkyloxycarbonyl, substituted or unsubstituted alkenyloxycarbonyl, substituted or unsubstituted alkynyloxycarbonyl, substituted or unsubstituted carbamoyl, substituted or unsubstituted amino, substituted or unsubstituted sulfamoyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, a substituted or unsubstituted non-aromatic heterocyclic group, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted cycloalkyloxy, substituted or unsubstituted cycloalkenyloxy, substituted or unsubstituted non-aromatic heterocyclic ring-oxy, substituted or unsubstituted aryloxy, or substituted or unsubstituted heteroaryloxy, or a pharmaceutically acceptable salt thereof.
 4. The method of claim 1, wherein R³ is a group represented by the formula:

wherein R⁹ is halogen, hydroxy, cyano, nitro, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted alkyloxy, substituted or unsubstituted alkenyloxy, substituted or unsubstituted alkynyloxy, substituted or unsubstituted alkylthio, substituted or unsubstituted alkenylthio, substituted or unsubstituted alkynylthio, substituted or unsubstituted acyl, carboxy, substituted or unsubstituted alkyloxycarbonyl, substituted or unsubstituted alkenyloxycarbonyl, substituted or unsubstituted alkynyloxycarbonyl, substituted or unsubstituted carbamoyl, substituted or unsubstituted amino, substituted or unsubstituted sulfamoyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, a substituted or unsubstituted non-aromatic heterocyclic group, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted cycloalkyloxy, substituted or unsubstituted cycloalkenyloxy, substituted or unsubstituted non-aromatic heterocyclic ring-oxy, substituted or unsubstituted aryloxy, or substituted or unsubstituted heteroaryloxy, or a pharmaceutically acceptable salt thereof; and R¹⁰ is substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, a substituted or unsubstituted non-aromatic heterocyclic group, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl, or a pharmaceutically acceptable salt thereof. 